{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:43:16Z","timestamp":1791380596866,"version":"4.3.3"},"reference-count":23,"publisher":"Japanese Society of Internal Medicine","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2015]]},"DOI":"10.2169\/internalmedicine.54.4687","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T18:01:19Z","timestamp":1442253679000},"page":"2395-2399","source":"Crossref","is-referenced-by-count":3,"title":["Polycythemia Vera Diagnosed after Esophageal Variceal Rupture"],"prefix":"10.2169","volume":"54","author":[{"given":"Yoshiyasu","family":"Kono","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinobu","family":"Takaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Gobara","sequence":"additional","affiliation":[{"name":"Department of Radiology, Okayama University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Okayama University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Okayama Kyouritsu Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Okayama University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Stuart BJ, Viera AJ. Polycythemia vera. Am Fam Physician 69: 2139-2144, 2004."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Smalberg JH, Arends LR, Valla DC, Kiladjian JJ, Janssen HL, Leebeek FW. Myeloproliferative neoplasms in budd-chiari syndrome and portal vein thrombosis: a meta-analysis. Blood 120: 4921-4928, 2012.","DOI":"10.1182\/blood-2011-09-376517"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Aksu T, Erdem AY, Fettah A, et al. Massive splenic infarction and portal vein thrombosis in children with chronic myeloid leukemia. J Pediatr Hematol Oncol 36: e471-e472, 2014.","DOI":"10.1097\/MPH.0000000000000204"},{"key":"4","unstructured":"4. Olveda DU, Olveda RM, Montes CJ, et al. Clinical management of advanced schistosomiasis: a case of portal vein thrombosis-induced splenomegaly requiring surgery. BMJ Case Rep 2014: piiibcr2014203897, 2014."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Fisher NC, Wilde JT, Roper J, Elias E. Deficiency of natural anticoagulant proteins c, s, and antithrombin in portal vein thrombosis: a secondary phenomenon? Gut 46: 534-539, 2000.","DOI":"10.1136\/gut.46.4.534"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Qi X, Ren W, De Stefano V, Fan D. Associations of coagulation factor V Leiden and prothrombin G20210A mutations with Budd-Chiari syndrome and portal vein thrombosis: A systematic review and meta-analysis. Clin Gastroenterol Hepatol 12: 1801-12.e7, 2014.","DOI":"10.1016\/j.cgh.2014.04.026"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Webster GJ, Burroughs AK, Riordan SM. Review article: portal vein thrombosis: new insights into aetiology and management. Aliment Pharmacol Ther 21: 1-9, 2005.","DOI":"10.1111\/j.1365-2036.2004.02301.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Staerk J, Constantinescu SN. The jak-stat pathway and hematopoietic stem cells from the jak2 v617f perspective. Jak-Stat 1: 184-190, 2012.","DOI":"10.4161\/jkst.22071"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Baxter EJ, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase jak2 in human myeloproliferative disorders. Lancet 365: 1054-1061, 2005.","DOI":"10.1016\/S0140-6736(05)74230-6"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. James C, Ugo V, Le Couedic JP, et al. A unique clonal jak2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434: 1144-1148, 2005.","DOI":"10.1038\/nature03546"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of jak2 in myeloproliferative disorders. N Engl J Med 352: 1779-1790, 2005.","DOI":"10.1056\/NEJMoa051113"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase jak2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7: 387-397, 2005.","DOI":"10.1016\/j.ccr.2005.03.023"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Polycythemia vera: The natural history of 1213 patients followed for 20 years. Gruppo Italiano Studio Policitemia. Ann Inter Med 123: 656-664, 1995.","DOI":"10.7326\/0003-4819-123-9-199511010-00003"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Campbell PJ, Green AR. Management of polycythemia vera and essential thrombocythemia. Hematology\/the Education Program of the American Society of Hematology American Society of Hematology Education Program. 2005: 201-208.","DOI":"10.1182\/asheducation-2005.1.201"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Wanless IR, Peterson P, Das A, Boitnott JK, Moore GW, Bernier V. Hepatic vascular disease and portal hypertension in polycythemia vera and agnogenic myeloid metaplasia: a clinicopathological study of 145 patients examined at autopsy. Hepatology (Baltimore, Md) 12: 1166-1174, 1990.","DOI":"10.1002\/hep.1840120515"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Tefferi A, Rumi E, Finazzi G, et al. Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study. Leukemia 27: 1874-1881, 2013.","DOI":"10.1038\/leu.2013.163"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Tefferi A, Guglielmelli P, Larson DR, et al. Long-term survival and blast transformation in molecularly annotated essential thrombocythemia, polycythemia vera, and myelofibrosis. Blood 124: 2507-2513; quiz 2615, 2014.","DOI":"10.1182\/blood-2014-05-579136"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Ward HP, Block MH. The natural history of agnogenic myeloid metaplasia (amm) and a critical evaluation of its relationship with the myeloproliferative syndrome. Medicine 50: 357-420, 1971.","DOI":"10.1097\/00005792-197109000-00001"},{"key":"19","unstructured":"19. Sullivan A, Rheinlander H, Weintraub LR. Esophageal varices in agnogenic myeloid metaplasia: disappearance after splenectomy. A case report. Gastroenterology 66: 429-432, 1974."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Barbui T, Barosi G, Birgegard G, et al. Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from european leukemianet. J Clin Oncol 29: 761-770, 2011.","DOI":"10.1200\/JCO.2010.31.8436"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Sever M, Newberry KJ, Verstovsek S. Therapeutic options for patients with polycythemia vera and essential thrombocythemia refractory\/resistant to hydroxyurea. Leuk Lymphoma 55: 2685-2690, 2014.","DOI":"10.3109\/10428194.2014.893310"},{"key":"22","unstructured":"22. Lukie BE, Card RT. Portal hypertension complicating myelofibrosis: reversal following splenectomy. Can Med Assoc J 117: 771-772, 1977."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Cortelazzo S, Viero P, Finazzi G, D'Emilio A, Rodeghiero F, Barbui T. Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia. J Clin Oncol 8: 556-562, 1990.","DOI":"10.1200\/JCO.1990.8.3.556"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/54\/18\/54_54.4687\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T10:31:00Z","timestamp":1567161060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/54\/18\/54_54.4687\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":23,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.54.4687","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}