{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:28:40Z","timestamp":1774358920908,"version":"3.50.1"},"reference-count":16,"publisher":"Japanese Society of Internal Medicine","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2015]]},"DOI":"10.2169\/internalmedicine.54.4735","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T22:04:22Z","timestamp":1447538662000},"page":"2851-2855","source":"Crossref","is-referenced-by-count":5,"title":["Multiple Intestinal Ulcers Associated with Primary Epstein-Barr Virus Infection in a Patient with Rheumatoid Arthritis Undergoing Methotrexate Therapy"],"prefix":"10.2169","volume":"54","author":[{"given":"Yuichi","family":"Makino","sequence":"first","affiliation":[{"name":"Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikayoshi","family":"Tani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological and General Surgery, Department of Surgery, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Miyokawa","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsutoshi","family":"Mizumoto","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Kodama","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Komura","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensaku","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological and General Surgery, Department of Surgery, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Haneda","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Weinblatt ME, Coblyn JS, Fox DA, et al. Efficacy of low-dose methotrexate in rheumatoid arthritis. N Engl J Med 312: 818-822, 1985.","DOI":"10.1056\/NEJM198503283121303"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Salloum E, Cooper DL, Howe G, et al. Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases. J Clin Oncol 14: 1943-1949, 1996.","DOI":"10.1200\/JCO.1996.14.6.1943"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kamel OW, van de Rijn M, Weiss LM, et al. Brief report: reversible lymphomas associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis. N Engl J Med 328: 1317-1321, 1993.","DOI":"10.1056\/NEJM199305063281806"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Feng WH, Cohen JI, Fischer S, et al. Reactivation of latent Epstein-Barr virus by methotrexate: a potential contributor to methotrexate-associated lymphomas. J Natl Cancer Inst 96: 1691-1702, 2004.","DOI":"10.1093\/jnci\/djh313"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Alspaugh MA, Henle G, Lennette ET, Henle W. Elevated levels of antibodies to Epstein-Barr virus antigens in sera and synovial fluids of patients with rheumatoid arthritis. J Clin Invest 67: 1134-1140, 1981.","DOI":"10.1172\/JCI110127"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Tosato G, Steinberg AD, Blaese RM. Defective EBV-specific suppressor T-cell function in rheumatoid arthritis. N Engl J Med 305: 1238-1243, 1981.","DOI":"10.1056\/NEJM198111193052102"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Tosato G, Steinberg AD, Yarchoan R, et al. Abnormally elevated frequency of Epstein-Barr virus-infected B cells in the blood of patients with rheumatoid arthritis. J Clin Invest 73: 1789-1795, 1984.","DOI":"10.1172\/JCI111388"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Dojcinov SD, Venkataraman G, Raffeld M, Pittaluga S, Jaffe ES. EBV positive mucocutaneous ulcer--a study of 26 cases associated with various sources of immunosuppression. Am J Surg Pathol 34: 405-417, 2010.","DOI":"10.1097\/PAS.0b013e3181cf8622"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Yamakawa N, Fujimoto M, Kawabata D, et al. A clinical, pathological, and genetic characterization of methotrexate-associated lymphoproliferative disorders. J Rheumatol 41: 293-299, 2014.","DOI":"10.3899\/jrheum.130270"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Hisamatsu A, Nagai T, Okawara H, et al. Gastritis associated with Epstein-Barr virus infection. Intern Med 49: 2101-2105, 2010.","DOI":"10.2169\/internalmedicine.49.3789"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Sujino T, Ebinuma H, Hosoe N, et al. Epstein-barr virus-associated gastritis: a case report. Dig Dis Sci 58: 883-886, 2013.","DOI":"10.1007\/s10620-012-2390-2"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kitayama Y, Honda S, Sugimura H. Epstein-Barr virus-related gastric pseudolymphoma in infectious mononucleosis. Gastrointest Endosc 52: 290-291, 2000.","DOI":"10.1067\/mge.2000.107715"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Clayton RA, Malcomson RD, Gilmour HM, Crawford DH, Parks RW. Profuse gastrointestinal haemorrhage due to delayed primary Epstein-Barr virus infection in an immunocompetent adult. Histopathology 47: 439-441, 2005.","DOI":"10.1111\/j.1365-2559.2005.02130.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Chen ZM, Shah R, Zuckerman GR, Wang HL. Epstein-Barr virus gastritis: an underrecognized form of severe gastritis simulating gastric lymphoma. Am J Surg Pathol 31: 1446-1451, 2007.","DOI":"10.1097\/PAS.0b013e318050072f"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Tashiro Y, Goto M, Takemoto Y, et al. Epstein-Barr virus-associated enteritis with multiple ulcers after stem cell transplantation: first histologically confirmed case. Pathol Int 56: 530-537, 2006.","DOI":"10.1111\/j.1440-1827.2006.02001.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kutok JL, Wang F. Spectrum of Epstein-Barr virus-associated diseases. Annu Rev Pathol 1: 375-404, 2006.","DOI":"10.1146\/annurev.pathol.1.110304.100209"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/54\/22\/54_54.4735\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T23:41:53Z","timestamp":1498261313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/54\/22\/54_54.4735\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":16,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.54.4735","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}