{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:55:31Z","timestamp":1792803331124,"version":"4.5.0"},"reference-count":21,"publisher":"Japanese Society of Internal Medicine","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2015]]},"DOI":"10.2169\/internalmedicine.54.5069","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T17:02:54Z","timestamp":1450112574000},"page":"3171-3176","source":"Crossref","is-referenced-by-count":4,"title":["Hydroxyurea-induced Pneumonitis in a Patient with Chronic Myelomonocytic Leukemia: An Autopsy Case"],"prefix":"10.2169","volume":"54","author":[{"given":"Hisao","family":"Imai","sequence":"first","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohito","family":"Kuwako","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Kamide","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Tomizawa","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeki","family":"Mitsui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoichi","family":"Kaira","sequence":"additional","affiliation":[{"name":"Department of Oncology Clinical Development, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Shibusawa","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Sunaga","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Hisada","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Patnaik MM, Parikh SA, Hanson CA, Tefferi A. Chronic myelomonocytic leukaemia: a concise clinical and pathophysiological review. Br J Haematol 165: 273-286, 2014.","DOI":"10.1111\/bjh.12756"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Parikh SA, Tefferi A. Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management. Am J Hematol 88: 967-974, 2013.","DOI":"10.1002\/ajh.23574"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Wattel E, Guerci A, Hecquet B, et al. A randomized trial of hydroxyurea versus VP16 in adult chronic myelomonocytic leukemia. Groupe Francais des Myelodysplasies and European CMML Group. Blood 88: 2480-2487, 1996.","DOI":"10.1182\/blood.V88.7.2480.bloodjournal8872480"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Twohig KJ, Matthay RA. Pulmonary effects of cytotoxic agents other than bleomycin. Clin Chest Med 11: 31-54, 1990.","DOI":"10.1016\/S0272-5231(21)00670-5"},{"key":"5","unstructured":"5. Kreisman H, Wolkove N. Pulmonary toxicity of antineoplastic therapy. Semin Oncol 19: 508-520, 1992."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Dingli D, Utz JP, Krowka MJ, Oberg AL, Tefferi A. Unexplained pulmonary hypertension in chronic myeloproliferative disorders. Chest 120: 801-808, 2001.","DOI":"10.1378\/chest.120.3.801"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Yusen RD, Kollef MH. Acute respiratory failure due to extramedullary hematopoiesis. Chest 108: 1170-1172, 1995.","DOI":"10.1378\/chest.108.4.1170"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Sandhu HS, Barnes PJ, Hernandez P. Hydroxyurea-induced hypersensitivity pneumonitis: a case report and literature review. Can Respir J 7: 491-495, 2000.","DOI":"10.1155\/2000\/297045"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Wong CC, Brown D, Howling SJ, Parker NE. Hydroxyurea-induced pneumonitis in a patient with chronic idiopathic myelofibrosis after prolonged drug exposure. Eur J Haematol 71: 388-390, 2003.","DOI":"10.1034\/j.1600-0609.2003.00123.x"},{"key":"10","unstructured":"10. Internullo M, Giannelli V, Sardo L, et al. Hydroxyurea-induced interstitial pneumonitis: case report and review of the literature. Eur Rev Med Pharmacol Sci 18: 190-193, 2014."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Cortelazzo S, Finazzi G, Ruggeri M, et al. Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. N Engl J Med 332: 1132-1136, 1995.","DOI":"10.1056\/NEJM199504273321704"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Gowin K, Mesa R. Management of thrombocythemia. F1000Res 3: 227, 2014.","DOI":"10.12688\/f1000research.5361.1"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Stein BL, Moliterno AR, Tiu RV. Polycythemia vera disease burden: contributing factors, impact on quality of life, and emerging treatment options. Ann Hematol 93: 1965-1976, 2014.","DOI":"10.1007\/s00277-014-2205-y"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Halsey C, Roberts IA. The role of hydroxyurea in sickle cell disease. Br J Haematol 120: 177-186, 2003.","DOI":"10.1046\/j.1365-2141.2003.03849.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Rossi SE, Erasmus JJ, McAdams HP, Sporn TA, Goodman PC. Pulmonary drug toxicity: radiologic and pathologic manifestations. Radiographics 20: 1245-1259, 2000.","DOI":"10.1148\/radiographics.20.5.g00se081245"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Cleverley JR, Screaton NJ, Hiorns MP, Flint JD, Müller NL. Drug-induced lung disease: high-resolution CT and histological findings. Clin Radiol 57: 292-299, 2002.","DOI":"10.1053\/crad.2001.0792"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hennemann B, Bross KJ, Reichle A, Andreesen R. Acute alveolitis induced by hydroxyurea in a patient with myeloproliferative syndrome. Ann Hematol 67: 133-134, 1993.","DOI":"10.1007\/BF01701737"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Kavuru MS, Gadsden T, Lichtin A, Gephardt G. Hydroxyurea-induced acute interstitial lung disease. South Med J 87: 767-769, 1994.","DOI":"10.1097\/00007611-199407000-00022"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Quintas-Cardama A, Pérez-Encinas M, Gonzalez S, Bendaña A, Bello JL. Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia. Ann Hematol 78: 187-188, 1999.","DOI":"10.1007\/s002770050498"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Loo PS, Khan M, Currie GP, Husain E, Kerr KM. Hydroxycarbamide-induced pneumonitis. Histopathology 55: 234-236, 2009.","DOI":"10.1111\/j.1365-2559.2009.03340.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Jackson GH, Wallis J, Ledingham J, Lennard A, Proctor SJ. Hydroxyurea-induced acute alveolitis in a patient with chronic myeloid leukaemia. Cancer Chemother Pharmacol 27: 168-169, 1990.","DOI":"10.1007\/BF00689105"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/54\/24\/54_54.5069\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T04:16:22Z","timestamp":1653797782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/54\/24\/54_54.5069\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":21,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.54.5069","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}