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N Engl J Med 335: 848-854, 1996.","DOI":"10.1056\/NEJM199609193351203"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hoeg JM, Osborne JC Jr, Gregg RE, Brewer HB Jr. Initial diagnosis of lipoprotein lipase deficiency in a 75-year-old man. Am J Med 75: 889-892, 1983.","DOI":"10.1016\/0002-9343(83)90423-0"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Ma Y, Liu MS, Chitayat D, et al. Recurrent missense mutations at the first and second base of codon Arg243 in human lipoprotein lipase in patients of different ancestries. Hum Mutat 3: 52-58, 1994.","DOI":"10.1002\/humu.1380030109"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Saika Y, Sakai N, Takahashi M, et al. Novel LPL mutation (L303F) found in a patient associated with coronary artery disease and severe systemic atherosclerosis. Eur J Clin Investigat 33: 216-222, 2003.","DOI":"10.1046\/j.1365-2362.2003.01129.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Sbrana F, Puntoni M, Bigazzi F, et al. Cognitive impairment and polidistrectual atherosclerotic disease in chylomicronemia syndrome: a case report. Transfus Apher Sci 49: 323-327, 2013.","DOI":"10.1016\/j.transci.2013.06.017"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Gotoda T, Yamada N, Kawamura M, et al. Heterogeneous mutations in the human lipoprotein lipase gene in patients with familial lipoprotein lipase deficiency. J Clin Invest 88: 1856-1864, 1991.","DOI":"10.1172\/JCI115507"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Fredrickson DS, Lees RS. A system for phenotyping hyperlipoproteinemia. Circulation 31: 321-327, 1965.","DOI":"10.1161\/01.CIR.31.3.321"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Wittrup HH, Tybjaerg-Hansen A, Abildgaard S, Steffensen R, Schnohr P, Nordestgaard BG. A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease. J Clin Invest 99: 1606-1613, 1997.","DOI":"10.1172\/JCI119323"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Havel RJ, Gordon RS Jr. Idiopathic hyperlipemia: metabolic studies in an affected family. J Clin Invest 39: 1777-1790, 1960.","DOI":"10.1172\/JCI104202"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Winkler FK, D'Arcy A, Hunziker W. Structure of human pancreatic lipase. Nature 343: 771-774, 1990.","DOI":"10.1038\/343771a0"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Clee SM, Bissada N, Miao F, et al. Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis. J Lipid Res 41: 521-531, 2000.","DOI":"10.1016\/S0022-2275(20)32399-3"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Ebara T, Okubo M, Horinishi A, Adachi M, Murase T, Hirano T. No evidence of accelerated atherosclerosis in a 66-yr-old chylomicronemia patient homozygous for the nonsense mutation (Tyr61→stop) in the lipoprotein lipase gene. Atherosclerosis 159: 375-379, 2001.","DOI":"10.1016\/S0021-9150(01)00510-X"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kawashiri MA, Higashikata T, Mizuno M, et al. Long-term course of lipoprotein lipase (LPL) deficiency due to homozygous LPL (Arita) in a patient with recurrent pancreatitis, retained glucose tolerance, and atherosclerosis. J Clin Endocrinol Metab 90: 6541-6544, 2005.","DOI":"10.1210\/jc.2005-1098"},{"key":"17","unstructured":"17. Patel MI, Hardman DT, Fisher CM, Appleberg M. Current views on the pathogenesis of abdominal aortic aneurysms. J Am Coll Surg 181: 371-382, 1995."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Stather PW, Sidloff DA, Dattani N, et al. Meta-analysis and meta-regression analysis of biomarkers for abdominal aortic aneurysm. Br J Surg 101: 1358-1372, 2014.","DOI":"10.1002\/bjs.9593"},{"key":"19","unstructured":"19. Furman RH, Howard RP, Brusco OJ, Alaupovic P. Effects of medium chain length triglyceride (MCT) on serum lipids and lipoproteins in familial hyperchylomicronemia (dietary fat-induced lipemia) and dietary carbohydrate-accentuated lipemia. J Lab Clin Med 66: 912-926, 1965."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Bach AC, Ingenbleek Y, Frey A. The usefulness of dietary medium-chain triglycerides in body weight control: fact or fancy? J Lipid Res 37: 708-726, 1996.","DOI":"10.1016\/S0022-2275(20)37570-2"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Greenberger NJ, Skillman TG. Medium-chain triglycerides. N Engl J Med 280: 1045-1058, 1969.","DOI":"10.1056\/NEJM196905082801906"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Tremblay AJ, Lamarche B, Labonté MÈ, Lépine MC, Lemelin V, Couture P. 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