{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:01:57Z","timestamp":1780498917940,"version":"3.54.1"},"reference-count":12,"publisher":"Japanese Society of Internal Medicine","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2016]]},"DOI":"10.2169\/internalmedicine.55.6024","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T22:08:30Z","timestamp":1462054110000},"page":"1125-1129","source":"Crossref","is-referenced-by-count":8,"title":["Two Sisters with Graves' Disease and Similar Clinical Features who Tested Positive for Anti-insulin Antibodies after Thiamazole Treatment"],"prefix":"10.2169","volume":"55","author":[{"given":"Keiichi","family":"Torimoto","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Okada","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Mori","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiya","family":"Tanaka","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Hirata Y, Ishizu H, Ouchi N, et al. Insulin autoimmunity in a case with spontaneous hypoglycemia. Tonyobyo (Diabetes) 13: 312-320, 1970 (in Japanese, Abstract in English)."},{"key":"2","unstructured":"2. Uchigata Y, Hirata Y. Insulin autoimmune syndrome (IAS, Hirata disease). Ann Med Interne (Paris) 150: 245-253, 1999."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Uchigata Y. Insulin autoimmune syndrome (Hirata disease): epidemiology in Asia, including Japan. Diabetol Int 1: 21-25, 2010.","DOI":"10.1007\/s13340-010-0001-z"},{"key":"4","unstructured":"4. Eguchi Y. Scatchard analysis of insulin autoantibodies in the insulin autoimmune syndrome. Tokyo Jyoshi Ika Daigaku Zasshi (J Tokyo Women's Med Uni) 59: 1296-1305, 1989 (in Japanese, Abstract in English)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kim MR, Sheeler LR, Mansharamani N, Haug MT, Faiman C, Gupta MK. Insulin antibodies and hypoglycemia in diabetic patients. Can a quantitative analysis of antibody binding predict the risk of hypoglycemia? Endocrine 6: 285-291, 1997.","DOI":"10.1007\/BF02820505"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Uchigata Y, Hirata Y, Iwamoto Y. Drug-induced insulin autoimmune syndrome. Diabetes Res Clin Pract 83: e19-e20, 2009.","DOI":"10.1016\/j.diabres.2008.10.015"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Uchigata Y, Tokunaga K, Nepom G, et al. Differential immunogenetic determinants of polyclonal insulin autoimmune syndrome (Hirata's disease) and monoclonal insulin autoimmune syndrome. Diabetes 44: 1227-1232, 1995.","DOI":"10.2337\/diab.44.10.1227"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Hirata Y. Methimazole and insulin autoimmune syndrome with hypoglycemia. Lancet 2 (8357): 1037-1038, 1983.","DOI":"10.1016\/S0140-6736(83)91031-0"},{"key":"9","unstructured":"9. Uchigata Y, Omori Y. Endocrine. Interesting case. Clinical features of insulin autoimmune syndromes (Hirata disease) of Japanese 212 subjects. Horumon to Rinsyo (Clin Endocrinol) 42: 229-232, 1994 (in Japanese)."},{"key":"10","unstructured":"10. Kondou S, Hidaka S, Kashima J, Mitsutomi K, Fujitomi Y, Yoshimatsu H. Insulin autoimmune syndrome in an 89-year-old woman : the oldest age of onset ever to be reported in Japan. Tonyobyo (Diabetes) 56: 227-234, 2013 (in Japanese, Abstract in English)."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Eguchi Y, Uchigata Y, Yao K, Yokoyama H, Hirata Y, Omori Y. Longitudinal changes of serum insulin concentration and insulin antibody features in persistent insulin autoimmune syndrome (Hirata's disease). Autoimmunity 19: 279-284, 1994.","DOI":"10.3109\/08916939409071354"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Cavaco B, Uchigata Y, Porto T, Amparo-Santos M, Sobrinho L, Leite V. Hypoglycaemia due to insulin autoimmune syndrome: report of two cases with characterisation of HLA alleles and insulin autoantibodies. Eur J Endocrinol 145: 311-316, 2001.","DOI":"10.1530\/eje.0.1450311"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/55\/9\/55_55.6024\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T12:21:53Z","timestamp":1498306913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/55\/9\/55_55.6024\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.55.6024","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}