{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T11:21:04Z","timestamp":1749381664447},"reference-count":30,"publisher":"Japanese Society of Internal Medicine","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2016]]},"DOI":"10.2169\/internalmedicine.55.6230","type":"journal-article","created":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T22:08:18Z","timestamp":1470002898000},"page":"1997-2003","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of Vitamin K&lt;sub&gt;2&lt;\/sub&gt; for Glucocorticoid-induced Osteoporosis in Patients with Systemic Autoimmune Diseases"],"prefix":"10.2169","volume":"55","author":[{"given":"Kotaro","family":"Shikano","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaichi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Kawazoe","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kaburaki","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Hasunuma","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Japan"},{"name":"Clinical Pharmacology Center, Oita University Faculty of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Kawai","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Longo DL. Osteoporosis: glucocorticoid-induced osteoporosis. In: Harrison&apos;s Principles of Internal Medicine. 18th ed. Fauci A, Kasper D, Hauser S, Jameson J, Loscalzo J, Eds. McGraw-Hill Medical, New York, 2012: 3135."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Buttgereit F, Straub RH, Wehling M, Burmester GR. Glucocorticoids in the treatment of rheumatic disease: an update on the mechanisms of action. Arthritis Rheum 50: 3408-3417, 2004.","DOI":"10.1002\/art.20583"},{"key":"3","unstructured":"3. den Uyl D, Bultink IE, Lems WF. Glucocorticoid-induced osteoporosis. Clin Exp Rheumatol 29: S93-S98, 2011."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Maricic M. Update on glucocorticoid-induced osteoporosis. Rheum Dis Clin North Am 37: 415-431, 2011.","DOI":"10.1016\/j.rdc.2011.07.003"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Suzuki Y, Nawata H, Soen S, et al. Guidelines on the management and treatment of glucocorticoid-induced osteoporosis of the Japanese Society for Bone and Mineral Research: 2014 update. J Bone Miner Metab 32: 337-350, 2014.","DOI":"10.1007\/s00774-014-0586-6"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6. Hoang QQ, Sicheri F, Howard AJ, Yang DS. Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature 425: 977-980, 2003.","DOI":"10.1038\/nature02079"},{"key":"7","unstructured":"7. Hauschka PV, Lian JB, Cole DE, Gundberg CM. Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol Rev 69: 990-1047, 1989."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Vergnaud P, Garnero P, Meunier PJ, Br\u00e9art G, Kamihagi K, Delmas PD. Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab 82: 719-724, 1997.","DOI":"10.1210\/jc.82.3.719"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Szulc P, Arlot M, Chapuy MC, Duboeuf F, Meunier PJ, Delmas PD. Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. J Bone Miner Res 9: 1591-1595, 1994.","DOI":"10.1002\/jbmr.5650091012"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kanai T, Takagi T, Masuhiro K, Nakamura M, Iwata M, Saji F. Serum vitamin K level and bone mineral density in post-menopausal women. Int J Gynaecol Obstet 56: 25-30, 1997.","DOI":"10.1016\/S0020-7292(96)02790-7"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Hirao M, Hashimoto J, Ando W, Ono T, Yoshikawa H. Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K<sub>2<\/sub> in postmenopausal women. J Bone Miner Metab 26: 260-264, 2008.","DOI":"10.1007\/s00774-007-0823-3"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ishida Y, Kawai S. Comparative efficacy of hormone replacement therapy, etidronate, calcitonin, alfacalcidol, and vitamin K in postmenopausal women with osteoporosis. The Yamaguchi Osteoporosis Prevention Study. Am J Med 117: 549-555, 2004.","DOI":"10.1016\/j.amjmed.2004.05.019"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Shiraki M, Shiraki Y, Aoki C, Miura M. Vitamin K<sub>2<\/sub> (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res 15: 515-521, 2000.","DOI":"10.1359\/jbmr.2000.15.3.515"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Ushiroyama T, Ikeda A, Ueki M. Effect of continuous combined therapy with vitamin K<sub>2<\/sub> and vitamin D<sub>3<\/sub> on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas 41: 211-221, 2002.","DOI":"10.1016\/S0378-5122(01)00275-4"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Knapen MH, Schurgers LJ, Vermeer C. Vitamin K<sub>2<\/sub> supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int 18: 963-972, 2007.","DOI":"10.1007\/s00198-007-0337-9"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Ozuru R, Sugimoto T, Yamaguchi T, Chihara K. Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal women. Endocr J 49: 363-370, 2002.","DOI":"10.1507\/endocrj.49.363"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kaneko K, Kusunoki N, Hasunuma T, Kawai S. Changes of serum soluble receptor activator for nuclear factor-\u03baB ligand after glucocorticoid therapy reflect regulation of its expression by osteoblasts. J Clin Endocrinol Metab 97: E1909-E1917, 2012.","DOI":"10.1210\/jc.2012-1971"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Dovio A, Perazzolo L, Osella G, et al. Immediate fall of bone formation and transient increase of bone resorption in the course of high-dose, short-term glucocorticoid therapy in young patients with multiple sclerosis. J Clin Endocrinol Metab 89: 4923-4928, 2004.","DOI":"10.1210\/jc.2004-0164"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kuroki Y, Kaji H, Kawano S, et al. Short-term effects of glucocorticoid therapy on biochemical markers of bone metabolism in Japanese patients: a prospective study. J Bone Miner Metab 26: 271-278, 2008.","DOI":"10.1007\/s00774-007-0821-5"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kaji H, Kuroki Y, Murakawa Y, et al. Effect of alendronate on bone metabolic indices and bone mineral density in patients treated with high-dose glucocorticoid: a prospective study. Osteoporosis Int 21: 1565-1571, 2010.","DOI":"10.1007\/s00198-009-1110-z"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kauh E, Mixson L, Malice MP, et al. Prednisone affects inflammation, glucose tolerance, and bone turnover within hours of treatment in healthy individuals. Eur J Endocrinol 166: 459-467, 2010.","DOI":"10.1530\/EJE-11-0751"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Price PA. Vitamin K-dependent formation of bone Gla protein (osteocalcin) and its function. Vitam Horm 42: 65-108, 1985.","DOI":"10.1016\/S0083-6729(08)60061-8"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Koshihara Y, Hoshi K, Okawara R, Ishibashi H. Vitamin K stimulates osteoblastogenesis and inhibits osteoclastogenesis in human bone marrow cell culture. J Endocrinol 176: 339-348, 2003.","DOI":"10.1677\/joe.0.1760339"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Takeuchi Y, Suzawa M, Fukumoto S, Fujita T. Vitamin K<sub>2<\/sub> inhibits adipogenesis, osteoclastogenesis, and ODF\/RANK ligand expression in murine bone marrow cell cultures. Bone 27: 769-776, 2000.","DOI":"10.1016\/S8756-3282(00)00396-3"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Iwamoto J, Takeda T, Ichimura S. Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: a comparison with the effect of etidronate. J Orthop Sci 6: 487-492, 2001.","DOI":"10.1007\/s007760100002"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Yonemura K, Kimura M, Miyaji T, Hishida A. Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis. Calcif Tissue Int 66: 123-128, 2000.","DOI":"10.1007\/PL00005832"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Sasaki N, Kusano E, Takahashi H, et al. Vitamin K<sub>2<\/sub> inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). J Bone Miner Metab 23: 41-47, 2005.","DOI":"10.1007\/s00774-004-0539-6"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Ichikawa T, Horie-Inoue K, Ikeda K, Blumberg B, Inoue S. Steroid and xenobiotic receptor SXR mediates vitamin K<sub>2<\/sub>-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells. J Biol Chem 281: 16927-16934, 2006.","DOI":"10.1074\/jbc.M600896200"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Walton RJ, Preston CJ, Russell RCG, Kenis JA. An estimate of the turnover rate of rate of bone-derived olasm alkaline phosphatase in Paget&apos;s disease. Clin Chim Acta 63: 227-229, 1975.","DOI":"10.1016\/0009-8981(75)90167-9"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Peterkofsky B, Gosiewska A, Singh K, Pearlman S, Mahmoodian F. Species differences in cis-elements of the pro\u03b11(1) procollagen promoter and their binding proteins. J Cell Biochem 73: 408-422, 1999.","DOI":"10.1002\/(SICI)1097-4644(19990601)73:3<408::AID-JCB12>3.0.CO;2-D"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/55\/15\/55_55.6230\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T19:36:38Z","timestamp":1498332998000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/55\/15\/55_55.6230\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":30,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.55.6230","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}