{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T03:47:40Z","timestamp":1794023260196,"version":"4.8.0"},"reference-count":15,"publisher":"Japanese Society of Internal Medicine","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2016]]},"DOI":"10.2169\/internalmedicine.55.6827","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T22:09:57Z","timestamp":1476482997000},"page":"2979-2983","source":"Crossref","is-referenced-by-count":10,"title":["Metastatic Pancreatic Neuroendocrine Tumor that Progressed to Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome with Growth Hormone-releasing Hormone (GHRH) Production"],"prefix":"10.2169","volume":"55","author":[{"given":"Rie","family":"Tadokoro","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ueno","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Ohkawa","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Katakami","sequence":"additional","affiliation":[{"name":"Division of Clinical Research Sciences, Department of Medicine, Teikyo University Chiba Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matsuo","family":"Taniyama","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Nagasaka","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1159\/000085237","volume":"80","author":"U Pl\u00f6ckinger","year":"2004","unstructured":"1. Pl\u00f6ckinger U, Rindi G, Arnold R, et al. Guidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours. Neuroendocrinology 80: 394-424, 2004.","journal-title":"Neuroendocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3835","issn-type":"print"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ito T, Sasano H, Tanaka M, et al. Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan. J Gastroenterol 45: 234-243, 2010.","DOI":"10.1007\/s00535-009-0194-8"},{"key":"3","unstructured":"3. Bosman FT, Carneiro F, Hruban RH, et al. WHO Classification of Tumours of the Digestive System (World Health Organization Classification of Tumours). IARC Press, Lyon, 2010."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Katakami H, Hashida S, Hidaka H, Ishikawa E, Matsukura S. Development and clinical application of a highly sensitive enzyme immunoassay (EIA) for human growth hormone-releasing hormone (hGHRH) in plasma. Endocrine J 45: S67-S70, 1998.","DOI":"10.1507\/endocrj.45.Suppl_S67"},{"key":"5","unstructured":"5. Sasaki A, Sato S, Hanew K, et al. A case of ectopic ACTH syndrome associated with GRF secreting pancreatic tumor. Igakunoayumi (Journal of Clinical and Experimental Medicine) 141: 327-330, 1987 (Abstract in Japanese)."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Leveston SA, McKeel DW Jr, Buckley PJ, et al. Acromegaly and Cushing's syndrome associated with a foregut carcinoid tumor. J Clin Endocrinol Metab 53: 682-689, 1981.","DOI":"10.1210\/jcem-53-4-682"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Southgate HJ, Archbold GP, el-Sayed ME, Wright J, Marks V. Ectopic release of GHRH and ACTH from an adenoid cystic carcinoma resulting in acromegaly and complicated by pituitary infarction. Postgrad Med J 64: 145-148, 1988.","DOI":"10.1136\/pgmj.64.748.145"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Jansson JO, Svensson J, Bengtsson BA, et al. Acromegaly and Cushing's syndrome due to ectopic production of GHRH and ACTH by a thymic carcinoid tumour: in vitro responses to GHRH and GHRP-6. ClinEndocrinol (Oxf) 48: 243-250, 1998.","DOI":"10.1046\/j.1365-2265.1998.3471213.x"},{"key":"9","unstructured":"9. Tanaka S, Hiduka N, Tanabe M, et al. An ACTH-producing malignant thymic carcinoid complicated by a GHRH-producing tumor (abstract). Nihon Naibunpi Gakkai Zasshi (Folia Endocrinol Jap) 85: 194, 2009 (in Japanese)."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Wajchenberg BL, Mendonca BB, Liberman B, et al. Ectopic adrenocorticotropic hormone syndrome. Endocr Rev 15: 752-787, 1994.","DOI":"10.1210\/edrv-15-6-752"},{"key":"11","unstructured":"11. Patel FB, Khagi S, Daly KP, Lechan RM, Ummaritchot V, Saif MW. Pancreatic neuroendocrine tumor with ectopic adrenocorticotropin production: a case report and review of literature. Anticancer Res 33: 4001-4005, 2013."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kondo T, Matsuyama R, Ashihara H, et al. A case of ectopic adrenocorticotropic hormone-producing pancreatic neuroendocrine tumor with multiple liver metastases. Endocr J 57: 229-236, 2010.","DOI":"10.1507\/endocrj.K09E-179"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Borson-Chazot F, Garby L, Raverot G, et al. Acromegaly induced by ectopic secretion of GHRH: a review 30 years after GHRH discovery. Ann Endocrinol (Paris) 73: 497-502, 2012.","DOI":"10.1016\/j.ando.2012.09.004"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Ghazi AA, Amirbaigloo A, Dezfooli AA, et al. Ectopic acromegaly due to growth hormone releasing hormone. Endocrine 43: 293-302, 2013.","DOI":"10.1007\/s12020-012-9790-0"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Faglia G, Arosio M, Bazzoni N. Ectopic acromegaly. Endocrinol Metab Clin North Am 21: 575, 1992.","DOI":"10.1016\/S0889-8529(18)30203-2"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/55\/20\/55_55.6827\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T16:32:36Z","timestamp":1568478756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/55\/20\/55_55.6827\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":15,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.55.6827","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}