{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:15:56Z","timestamp":1773659756143,"version":"3.50.1"},"reference-count":21,"publisher":"Japanese Society of Internal Medicine","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2017]]},"DOI":"10.2169\/internalmedicine.56.7754","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T22:25:03Z","timestamp":1487111103000},"page":"455-459","source":"Crossref","is-referenced-by-count":10,"title":["The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation"],"prefix":"10.2169","volume":"56","author":[{"given":"Shigeo","family":"Godo","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan"},{"name":"Department of Emergency and Critical Care Medicine, Tohoku University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Tohoku University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoo","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Tohoku University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Tohoku University Hospital, Japan"},{"name":"Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Tohoku University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Kushimoto","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Tohoku University Hospital, Japan"},{"name":"Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Chamberlain JJ, Rhinehart AS, Shaefer CF Jr, Neuman A. Diagnosis and Management of Diabetes: Synopsis of the 2016 American Diabetes Association Standards of Medical Care in Diabetes. Ann Intern Med 164: 542-552, 2016.","DOI":"10.7326\/M15-3016"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. DeFronzo R, Fleming GA, Chen K, Bicsak TA. Metformin-associated lactic acidosis: current perspectives on causes and risk. Metabolism 65: 20-29, 2016.","DOI":"10.1016\/j.metabol.2015.10.014"},{"key":"3","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.2337\/diacare.27.7.1791","volume":"27","author":"RI Misbin","year":"2004","unstructured":"3. Misbin RI. The phantom of lactic acidosis due to metformin in patients with diabetes. Diabetes Care 27: 1791-1793, 2004.","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Kraut JA, Madias NE. Lactic acidosis. N Engl J Med 371: 2309-2319, 2014.","DOI":"10.1056\/NEJMra1309483"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Inzucchi SE, Lipska KJ, Mayo H, Bailey CJ, McGuire DK. Metformin in patients with type 2 diabetes and kidney disease: a systematic review. JAMA 312: 2668-2675, 2014.","DOI":"10.1001\/jama.2014.15298"},{"key":"6","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/01.CIR.58.3.566","volume":"58","author":"M Attas","year":"1978","unstructured":"6. Attas M, Hanley HG, Stultz D, Jones MR, McAllister RG. Fulminant beriberi heart disease with lactic acidosis: presentation of a case with evaluation of left ventricular function and review of pathophysiologic mechanisms. Circulation 58: 566-572, 1978.","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Imamura T, Kinugawa K. Shoshin beriberi with low cardiac output and hemodynamic deterioration treated dramatically by thiamine administration. Int Heart J 56: 568-570, 2015.","DOI":"10.1536\/ihj.15-033"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. McIntyre N, Stanley NN. Cardiac beriberi: two modes of presentation. Br Med J 3: 567-569, 1971.","DOI":"10.1136\/bmj.3.5774.567"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Luft FC. Lactic acidosis update for critical care clinicians. J Am Soc Nephrol 12: S15-S19, 2001.","DOI":"10.1681\/ASN.V12suppl_1s15"},{"key":"10","unstructured":"10. Yamaguchi H, Iima T, Shirakami A, et al. A case of type 2 diabetes mellitus with severe lactic acidosis and beriberi heart disease during the administration of low-dose metformin. Tonyobyo (Journal of the Japan Diabetes Society) 57: 188-196, 2014 (in Japanese, Abstract in English)."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Sechi G, Serra A. Wernicke&apos;s encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol 6: 442-455, 2007.","DOI":"10.1016\/S1474-4422(07)70104-7"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kawano H, Koide Y, Toda G, Yano K. ST-segment elevation of electrocardiogram in a patient with Shoshin beriberi. Intern Med 44: 578-585, 2005.","DOI":"10.2169\/internalmedicine.44.578"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Donnino MW, Andersen LW, Chase M, et al. Randomized, double-blind, placebo-controlled trial of thiamine as a metabolic resuscitator in septic shock: a pilot study. Crit Care Med 44: 360-367, 2016.","DOI":"10.1097\/CCM.0000000000001572"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Singer P, Berger MM, Van den Berghe G, et al. ESPEN Guidelines on Parenteral Nutrition: intensive care. Clin Nutr 28: 387-400, 2009.","DOI":"10.1016\/j.clnu.2009.04.024"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Alston TA. Does metformin interfere with thiamine? Arch Intern Med 163: 983, 2003.","DOI":"10.1001\/archinte.163.8.983"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Liang X, Chien HC, Yee SW, et al. Metformin is a substrate and inhibitor of the human thiamine transporter, THTR-2 (SLC19A3). Mol Pharm 12: 4301-4310, 2015.","DOI":"10.1021\/acs.molpharmaceut.5b00501"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17. Thornalley PJ, Babaei-Jadidi R, Al Ali H, et al. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia 50: 2164-2170, 2007.","DOI":"10.1007\/s00125-007-0771-4"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Gilligan MA. Metformin and vitamin B12 deficiency. Arch Intern Med 162: 484-485, 2002.","DOI":"10.1001\/archinte.162.4.484"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Andres E, Noel E, Goichot B. Metformin-associated vitamin B12 deficiency. Arch Intern Med 162: 2251-2252, 2002.","DOI":"10.1001\/archinte.162.19.2251-a"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Tomkin GH, Hadden DR, Weaver JA, Montgomery DA. Vitamin-B12 status of patients on long-term metformin therapy. Br Med J 2: 685-687, 1971.","DOI":"10.1136\/bmj.2.5763.685"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Amrein K, Ribitsch W, Otto R, Worm HC, Stauber RE. Severe lactic acidosis reversed by thiamine within 24 hours. Crit Care 15: 457, 2011.","DOI":"10.1186\/cc10495"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/56\/4\/56_56.7754\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T04:17:23Z","timestamp":1658636243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/56\/4\/56_56.7754\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.56.7754","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}