{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:19:30Z","timestamp":1696360770876},"reference-count":25,"publisher":"Japanese Society of Internal Medicine","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2021,3,1]]},"DOI":"10.2169\/internalmedicine.5738-20","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T22:07:02Z","timestamp":1614550022000},"page":"675-680","source":"Crossref","is-referenced-by-count":2,"title":["Hypozincemia in Chronic Hepatitis C Is Improved with Viral Clearance by Direct-acting Antiviral Agents"],"prefix":"10.2169","volume":"60","author":[{"given":"Ryosaku","family":"Shirahashi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikuni","family":"Suda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Tamano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Moriyama M, Matsumura H, Fukushima A, et al. Clinical significance of evaluation of serum zinc concentrations in C-viral chronic liver disease. Dig Dis Sci 51: 1967-1977, 2006.","DOI":"10.1007\/s10620-005-9051-7"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Matsuoka S, Matsumura H, Nakamura H, et al. Zinc supplementation improves the outcome of chronic hepatitis C and liver cirrhosis. J Clin Biochem Nutr 45: 292-303, 2009.","DOI":"10.3164\/jcbn.jcbn08-246"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Matsumura H, Nirei K, Nakamura H, et al. Zinc supplementation therapy improves the outcome of patients with chronic hepatitis C. J Clin Biochem Nutr 51: 178-184, 2012.","DOI":"10.3164\/jcbn.12-11"},{"key":"4","unstructured":"4. Kawaguchi T, Nagao Y, Abe K, et al. Effects of branched-chain amino acids and zinc-enriched nutrients on prognosticators in HCV-infected patients: a multicenter randomized controlled trial. Mol Med Rep 11: 2159-2166, 2015."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hosui A, Kimura E, Abe S, et al. Long-term zinc supplementation improves liver function and decreases the risk of developing hepatocellular carcinoma. Nutrients 10: 1955, 2018.","DOI":"10.3390\/nu10121955"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Grungreiff K, Reinhold D, Ansorge S. Serum concentrations of sIL-2R, IL-6, TGF-beta1, neopterin, and zinc in chronic hepatitis C patients treated with interferon-alpha. Cytokine 11: 1076-1080, 1999.","DOI":"10.1006\/cyto.1999.0504"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Takagi H, Nagamine T, Abe T, et al. Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. J Viral Hepat 8: 367-371, 2001.","DOI":"10.1046\/j.1365-2893.2001.00311.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Suda T, Okawa O, Shirahashi R, Tokutomi N, Tamano M. Changes in serum zinc levels in hepatitis C patients before and after treatment with direct-acting antiviral agents. Hepatol Res 49: 1353-1356, 2019.","DOI":"10.1111\/hepr.13409"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Ko YL, Morihara D, Shibata K, et al. Factors attenuating zinc deficiency improvement in direct-acting antiviral agent-treated chronic hepatitis C virus infection. Nutrients 10: 1620, 2018.","DOI":"10.3390\/nu10111620"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Prasad AS. Clinical, endocrinological and biochemical effects of zinc deficiency. Clin Endocrinol Metab 14: 567-589, 1985.","DOI":"10.1016\/S0300-595X(85)80007-4"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Gupta S, Read SA, Shackel NA, Hebbard L, George J, Ahlenstiel G. The Role of micronutrients in the infection and subsequent response to hepatitis C virus. Cells 8: 603, 2019.","DOI":"10.3390\/cells8060603"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Wastney ME, Aamodt RL, Rumble WF, Henkin RI. Kinetic analysis of zinc metabolism and its regulation in normal humans. Am J Physiol 251: R398-R408, 1986.","DOI":"10.1152\/ajpregu.1986.251.2.R398"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Aggett PJ. Aspects of neonatal metabolism of trace metals. Acta Paediatr Suppl 402: 75-82, 1994.","DOI":"10.1111\/j.1651-2227.1994.tb13366.x"},{"key":"14","unstructured":"14. Prasad AS, Oberleas D. Binding of zinc to amino acids and serum proteins in vitro. J Lab Clin Med 76: 416-425, 1970."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Giroux EL, Durieux M, Schechter PJ. A study of zinc distribution in human serum. Bioinorg Chem 5: 211-218, 1976.","DOI":"10.1016\/S0006-3061(00)82019-0"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Katayama K, Kawaguchi T, Shiraishi K, et al. The prevalence and implication of zinc deficiency in patients with chronic liver disease. J Clin Med Res 10: 437-444, 2018.","DOI":"10.14740\/jocmr3374w"},{"key":"17","unstructured":"17. Nishikawa H, Enomoto H, Yoh K, et al. Serum zinc level grading system: a useful model for composite hepatic events in hepatitis C virus-associated liver cirrhosis. J Clin Med 9: 643, 2020."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Ozeki I, Arakawa T, Suii H, et al. Zinc deficiency in patients with chronic liver disease in Japan. Hepatol Res 50: 396-401, 2020.","DOI":"10.1111\/hepr.13465"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Enomoto M, Ikura Y, Tamori A, et al. Short-term histological evaluations after achieving a sustained virologic response to direct-acting antiviral treatment for chronic hepatitis C. United European Gastroenterol J 6: 1391-1400, 2018.","DOI":"10.1177\/2050640618791053"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Milne DB, Ralston NV, Wallwork JC. Zinc content of blood cellular components and lymph node and spleen lymphocytes in severely zinc-deficient rats. J Nutr 115: 1073-1078, 1985.","DOI":"10.1093\/jn\/115.8.1073"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ruz M, Cavan KR, Bettger WJ, Gibson RS. Erythrocytes, erythrocyte membranes, neutrophils and platelets as biopsy materials for the assessment of zinc status in humans. Br J Nutr 68: 515-527, 1992.","DOI":"10.1079\/BJN19920109"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Himoto T, Masaki T. Associations between zinc deficiency and metabolic abnormalities in patients with chronic liver disease. Nutrients 10: 88, 2018.","DOI":"10.3390\/nu10010088"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23. Love RA, Parge HE, Wickersham JA, et al. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell 87: 331-342, 1996.","DOI":"10.1016\/S0092-8674(00)81350-1"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Stempniak M, Hostomska Z, Nodes BR, Hostomsky Z. The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme. J Virol 71: 2881-2886, 1997.","DOI":"10.1128\/JVI.71.4.2881-2886.1997"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Tellinghuisen TL, Marcotrigiano J, Gorbalenya AE, Rice CM. The NS5A protein of hepatitis C virus is a zinc metalloprotein. J Biol Chem 279: 48576-48587, 2004.","DOI":"10.1074\/jbc.M407787200"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/60\/5\/60_5738-20\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T04:09:27Z","timestamp":1615003767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/60\/5\/60_5738-20\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.5738-20","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]}}}