{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:57:04Z","timestamp":1782842224727,"version":"3.54.5"},"reference-count":15,"publisher":"Japanese Society of Internal Medicine","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026,3,15]]},"DOI":"10.2169\/internalmedicine.5890-25","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T22:07:15Z","timestamp":1756332435000},"page":"840-845","source":"Crossref","is-referenced-by-count":2,"title":["Successful Management of Infective Endocarditis Utilizing Rapid High-performance Liquid Chromatography-based Therapeutic Drug Monitoring: Balancing Linezolid Efficacy and Thrombocytopenia Risk"],"prefix":"10.2169","volume":"65","author":[{"given":"Shunta","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Cardiology, Institute of Medicine, University of Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruriko","family":"Numata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute of Medicine, University of Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Machino-Ohtsuka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute of Medicine, University of Tsukuba, Japan"},{"name":"Department of Clinical Laboratory Medicine, Institute of Medicine, University of Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Institute of Medicine, University of Tsukuba, Japan"},{"name":"Department of Infectious Diseases, Faculty of Medicine, University of Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Ishizu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute of Medicine, University of Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Nakatani S, Ohara T, Ashihara K, et al.; Japanese Circulation Society Joint Working Group. JCS 2017 Guideline on Prevention and Treatment of Infective Endocarditis. Circ J 83: 1767-1809, 2019.","DOI":"10.1253\/circj.CJ-19-0549"},{"key":"2","unstructured":"2. Delgado V, Ajmone Marsan N, de Waha S, et al.; ESC Scientific Document Group. 2023 ESC Guidelines for the management of endocarditis. Eur Heart J 44: 3948-4042, 2023."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Zhang D, Xu Y, Wang X, et al. Risk factors for thrombocytopenia in patients receiving linezolid therapy: a systematic review and meta-analysis. Eur J Clin Pharmacol 79: 1303-1314, 2023.","DOI":"10.1007\/s00228-023-03542-z"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Chu VH, Miro JM, Hoen B, et al.; International Collaboration on Endocarditis-Prospective Cohort Study Group. Coagulase-negative staphylococcal prosthetic valve endocarditis - a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study. Heart 95: 570-576, 2009.","DOI":"10.1136\/hrt.2008.152975"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Langlois V, Lesourd A, Girszyn N, et al. Antineutrophil cytoplasmic antibodies associated with infective endocarditis. Medicine (Baltimore) 95: e2564, 2016.","DOI":"10.1097\/MD.0000000000002564"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. McDonald JR. Acute infective endocarditis. Infect Dis Clin North Am 23: 643-664, 2009.","DOI":"10.1016\/j.idc.2009.04.013"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Falagas ME, Manta KG, Ntziora F, Vardakas KZ. Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidence. J Antimicrob Chemother 58: 273-280, 2006.","DOI":"10.1093\/jac\/dkl219"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Reiter KC, Villa B, Paim TGDS, de Oliveira CF, d&apos;Azevedo PA. Inhibition of biofilm maturation by linezolid in meticillin-resistant Staphylococcus epidermidis clinical isolates: comparison with other drugs. J Med Microbiol 62: 394-399, 2013.","DOI":"10.1099\/jmm.0.048678-0"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Lahouati M, Brousse X, Bientz L, et al. Vancomycin versus linezolid for treatment of staphylococcal-associated central nervous system infections. BMC Infect Dis 25: 446, 2025.","DOI":"10.1186\/s12879-025-10834-5"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Cojutti PG, Merelli M, Bassetti M, Pea F. Proactive therapeutic drug monitoring (TDM) may be helpful in managing long-term treatment with linezolid safely: findings from a monocentric, prospective, open-label, interventional study. J Antimicrob Chemother 74: 3588-3595, 2019.","DOI":"10.1093\/jac\/dkz374"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Bea C, Vela S, Garc\u00eda-Blas S, et al. Infective endocarditis in the elderly: challenges and strategies. J Cardiovasc Dev Dis 9: 192, 2022.","DOI":"10.3390\/jcdd9060192"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Liu T, Yuan Y, Wang C, et al. Therapeutic drug monitoring of linezolid and exploring optimal regimens and a toxicity-related nomogram in elderly patients: a multicentre, prospective, non-interventional study. J Antimicrob Chemother 79: 1938-1950, 2024.","DOI":"10.1093\/jac\/dkae188"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Matsumoto K, Shigemi A, Takeshita A, et al. Analysis of thrombocytopenic effects and population pharmacokinetics of linezolid: a dosage strategy according to the trough concentration target and renal function in adult patients. Int J Antimicrob Agents 44: 242-247, 2014.","DOI":"10.1016\/j.ijantimicag.2014.05.010"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Oda K, Uchino S, Kurogi K, et al. Clinical evaluation of an authorized medical equipment based on high performance liquid chromatography for measurement of serum voriconazole concentration. J Pharm Health Care Sci 7: 42, 2021.","DOI":"10.1186\/s40780-021-00225-8"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Hashimoto N, Tsuda S, Kusama T, et al. Performance evaluation of high-performance liquid chromatography instrument in determining the serum concentration of linezolid. Yakugaku Zasshi (J Pharm Soc Jpn) 145: 553-560, 2025 (in Japanese, Abstract in English).","DOI":"10.1248\/yakushi.24-00213"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/6\/65_5890-25\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:33:25Z","timestamp":1774064005000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/6\/65_5890-25\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,15]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.5890-25","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,15]]},"article-number":"5890-25"}}