{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:44:34Z","timestamp":1787507074485,"version":"build-2736575974"},"reference-count":16,"publisher":"Japanese Society of Internal Medicine","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026,8,15]]},"DOI":"10.2169\/internalmedicine.5934-25","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T22:08:15Z","timestamp":1768428495000},"page":"2274-2279","source":"Crossref","is-referenced-by-count":2,"title":["Diffuse Large B-cell Lymphoma Presenting with Protein-losing Enteropathy during Treatment for Systemic Lupus Erythematosus"],"prefix":"10.2169","volume":"65","author":[{"given":"Shintaro","family":"Yasui","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukina","family":"Tanimoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Mugitani","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tenyu","family":"Sugano","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kobe University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Linley","family":"Sy-Janairo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kobe University Graduate School of Medicine, Japan"},{"name":"St. Luke&apos;s Medical Center - Global City Institute of Digestive and Liver Diseases, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kobe University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology\/Hematology, Kobe University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Saegusa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Ozen A, Lenardo MJ. Protein-losing enteropathy. N Engl J Med 389: 733-748, 2023.","DOI":"10.1056\/NEJMra2301594"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Mok CC, Ying KY, Mak A, To HC, Szeto ML. Outcome of protein-losing gastroenteropathy in systemic lupus erythematosus treated with prednisolone and azathioprine. Rheumatology (Oxford) 45: 425-429, 2006.","DOI":"10.1093\/rheumatology\/kei164"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Chng HH, Tan BE, Teh CL, Lian TY. Major gastrointestinal manifestations in lupus patients in Asia: lupus enteritis, intestinal pseudo-obstruction, and protein-losing gastroenteropathy. Lupus 19: 1404-1413, 2010.","DOI":"10.1177\/0961203310374337"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Chen Z, Li MT, Xu D, et al. Protein-losing enteropathy in systemic lupus erythematosus: 12 years experience from a Chinese academic center. PLOS ONE 9: e114684, 2014.","DOI":"10.1371\/journal.pone.0114684"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Werner de Castro GR, Appenzeller S, B\u00e9rtolo MB, Costallat LTL. Protein-losing enteropathy associated with systemic lupus erythematosus: response to cyclophosphamide. Rheumatol Int 25: 135-138, 2005.","DOI":"10.1007\/s00296-004-0483-8"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Williamson L, Hao Y, Basnayake C, Oon S, Nikpour M. Systematic review of treatments for the gastrointestinal manifestations of systemic lupus erythematosus. Semin Arthritis Rheum 69: 152567, 2024.","DOI":"10.1016\/j.semarthrit.2024.152567"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Ledermann HP, B\u00f6rner N, Strunk H, Bongartz G, Zollikofer C, Stuckmann G. Bowel wall thickening on transabdominal sonography. AJR Am J Roentgenol 174: 107-117, 2000.","DOI":"10.2214\/ajr.174.1.1740107"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Al-Mogairen SM. Lupus protein-losing enteropathy (LUPLE): a systematic review. Rheumatol Int 31: 995-1001, 2011.","DOI":"10.1007\/s00296-011-1827-9"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Klein A, Polliack A, Gafter-Gvili A. Systemic lupus erythematosus and lymphoma: incidence, pathogenesis and biology. Leuk Res 75: 45-49, 2018.","DOI":"10.1016\/j.leukres.2018.11.004"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Liang Y, Yang Z, Qin B, Zhong R. Primary Sj\u00f6gren&apos;s syndrome and malignancy risk: a systematic review and meta-analysis. Ann Rheum Dis 73: 1151-1156, 2014.","DOI":"10.1136\/annrheumdis-2013-203305"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Nakamura S, Matsumoto T, Iida M, Yao T, Tsuneyoshi M. Primary gastrointestinal lymphoma in Japan: a clinicopathologic analysis of 455 patients with special reference to its time trends. Cancer 97: 2462-2473, 2003.","DOI":"10.1002\/cncr.11415"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Lai Q, Zhao Y, Yan H, Peng H. Advances in diagnosis, treatment and prognostic factors of gastrointestinal DLBCL. Leuk Res 135: 107406, 2023.","DOI":"10.1016\/j.leukres.2023.107406"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Stanek N, Bauerfeind P, Herzog G, et al. Marginal zone lymphoma complicated by protein losing enteropathy. Case Rep Hematol 2016: 9351408, 2016.","DOI":"10.1155\/2016\/9351408"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Naymagon L, Ward S, Naymagon S, Navada S. Severe protein-losing enteropathy due to an indolent splenic lymphoma: case report and review of the literature. Clin Lymphoma Myeloma Leuk 19: e165-e168, 2019.","DOI":"10.1016\/j.clml.2018.12.015"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Minemura T, Kikuchi S, Mihara H, et al. Protein-losing enteropathy complicated with primary intestinal follicular lymphoma. Intern Med 61: 2051-2055, 2022.","DOI":"10.2169\/internalmedicine.8261-21"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Vetro C, Romano A, Amico I, et al. Endoscopic features of gastro-intestinal lymphomas: From diagnosis to follow-up. World J Gastroenterol 20: 12993-13005, 2014.","DOI":"10.3748\/wjg.v20.i36.12993"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/16\/65_5934-25\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T04:11:38Z","timestamp":1786767098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/16\/65_5934-25\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,15]]},"references-count":16,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.5934-25","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,15]]},"article-number":"5934-25"}}