{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:12:36Z","timestamp":1788581556749,"version":"build-2803163510"},"reference-count":13,"publisher":"Japanese Society of Internal Medicine","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026,9,1]]},"DOI":"10.2169\/internalmedicine.5948-25","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T22:08:15Z","timestamp":1768428495000},"page":"2346-2351","source":"Crossref","is-referenced-by-count":0,"title":["Treat-and-repair Strategy for Atrial Septal Defect with Eisenmenger Syndrome due to Pulmonary Arterial Hypertension"],"prefix":"10.2169","volume":"65","author":[{"given":"Muneyuki","family":"Kadota","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusuke","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine\/General Medicine, Tokushima University Graduate School of Biomedical Sciences, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Akagi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issei","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Hashimoto Clinic, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Saijo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Ise","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Soeki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Sata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Baumgartner H, De Backer J, Babu-Narayan SV, et al.; ESC Scientific Document Group. 2020 ESC Guidelines for the management of adult congenital heart disease: the Task Force for the management of adult congenital heart disease of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Adult Congenital Heart Disease (ISACHD). Eur Heart J 42: 563-645, 2021."},{"key":"2","unstructured":"2. JSC\/JSPCCS\/JSACHD 2025 Guideline on Management of Congenital Heart Diseases in Adults [Internet]. 2025. [cited 2025 May 8]. Available from: https:\/\/www.j-circ.or.jp\/cms\/wp-content\/uploads\/2025\/03\/JCS2025_Yamagishi.pdf"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kijima Y, Akagi T, Takaya Y, et al. Treat and repair strategy in patients with atrial septal defect and significant pulmonary arterial hypertension. Circ J 80: 227-234, 2016.","DOI":"10.1253\/circj.CJ-15-0599"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4. Geva T, Martins JD, Wald RM. Atrial septal defects. Lancet 383: 1921-1932, 2014.","DOI":"10.1016\/S0140-6736(13)62145-5"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Yao A, Inuzuka R, Mizuno A, et al.; JNCVD-ACHD investigators. Status of adult outpatients with congenital heart disease in Japan: the Japanese Network of Cardiovascular Departments for Adult Congenital Heart Disease Registry. J Cardiol 80: 525-531, 2022.","DOI":"10.1016\/j.jjcc.2022.07.019"},{"key":"6","unstructured":"6. Gali\u00e8 N, Humbert M, Vachiery JL, et al.; ESC Scientific Document Group. 2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: the Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Heart J 37: 67-119, 2016."},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Takaya Y, Akagi T, Sakamoto I, et al. Efficacy of treat-and-repair strategy for atrial septal defect with pulmonary arterial hypertension. Heart 108: 382-387, 2022.","DOI":"10.1136\/heartjnl-2021-319096"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Bradley EA, Ammash N, Martinez SC, et al.  "Treat-to-close": non-repairable ASD-PAH in the adult. Int J Cardiol 291: 127-133, 2019.","DOI":"10.1016\/j.ijcard.2019.03.056"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Akagi S, Kasahara S, Akagi T, et al. Feasibility of treat and repair strategy in congenital heart defects with pulmonary arterial hypertension. JACC Adv 3: 100887, 2024.","DOI":"10.1016\/j.jacadv.2024.100887"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Humenberger M, Rosenhek R, Gabriel H, et al. Benefit of atrial septal defect closure in adults: impact of age. Eur Heart J 32: 553-560, 2011.","DOI":"10.1093\/eurheartj\/ehq352"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. D'Alto M, Romeo E, Argiento P, et al. Hemodynamics of patients developing pulmonary arterial hypertension after shunt closure. Int J Cardiol 168: 3797-3801, 2013.","DOI":"10.1016\/j.ijcard.2013.06.036"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Cho YH, Jun TG, Yang JH, et al. Surgical strategy in patients with atrial septal defect and severe pulmonary hypertension. Heart Surg Forum 15: 111, 2012.","DOI":"10.1532\/HSF98.20111085"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Wang JK, Chiu SN, Lin MT, Chen CA, Lu CW, Wu MH. Transcatheter closure of atrial septal defect associated with pulmonary artery hypertension using fenestrated devices. Am J Cardiol 147: 122-128, 2021.","DOI":"10.1016\/j.amjcard.2021.01.025"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/17\/65_5948-25\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:31:10Z","timestamp":1788579070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/17\/65_5948-25\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":13,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.5948-25","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"article-number":"5948-25"}}