{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:45:51Z","timestamp":1774075551379,"version":"3.50.1"},"reference-count":24,"publisher":"Japanese Society of Internal Medicine","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026,3,15]]},"DOI":"10.2169\/internalmedicine.5979-25","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T22:07:30Z","timestamp":1755122850000},"page":"895-899","source":"Crossref","is-referenced-by-count":0,"title":["A Patient with Pustulotic Arthro-osteitis with Isolated Spinal Lesions Successfully Treated with Risankizumab"],"prefix":"10.2169","volume":"65","author":[{"given":"Kiysohi","family":"Migita","sequence":"first","affiliation":[{"name":"Department of Rheumatology, St Francisco Hospital, Japan"},{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine, Japan"},{"name":"Clinical Research Center, Nagasaki Medical Center, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazufumi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Francisco Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumi","family":"Mori","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology, St Francisco Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fukushima Medical University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Isomoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, St Francisco Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Misiak-Galazka M, Zozula J, Rudnicka L. Palmoplantar pustulosis: recent advances in etiopathogenesis and emerging treatments. Am J Clin Dermatol 21: 355-370, 2020.","DOI":"10.1007\/s40257-020-00503-5"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Yamamoto T. Pustulotic arthro-osteitis associated with palmoplantar pustulosis. J Dermatol 40: 857-863, 2013.","DOI":"10.1111\/1346-8138.12272"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Yamamoto T. Triggering role of focal infection in the induction of extra-palmoplantar lesions and pustulotic arthro-osteitis associated with palmoplantar pustulosis. Adv Otorhinolaryngol 72: 89-92, 2011.","DOI":"10.1159\/000324620"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Brunasso Vernetti AMG, Puntoni M, Massone C. Palmoplantar pustulosis and allergies: a systematic review. Dermatol Pract Concept 9: 105-110, 2019.","DOI":"10.5826\/dpc.0902a05"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Xu JM, Wang HM, Jin HE. An update date on therapeutic options for palmoplantar pustulosis: a narrative review and expert recommendations. Expert Rev Clin Immunol 19: 499-516, 2023.","DOI":"10.1080\/1744666X.2023.2185775"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Murakami M, Terui T. Palmoplantar pustulosis: current understanding of disease definition and pathomechanism. J Dermatol Sci 98: 13-19, 2020.","DOI":"10.1016\/j.jdermsci.2020.03.003"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Obeid G, Do G, Kirby L, Hughes C, Sbidian E, Le Cleach L. Interventions for chronic palmoplantar pustulosis. Cochrane Database Syst Rev 1: CD011628, 2020.","DOI":"10.1002\/14651858.CD011628.pub2"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Leong HF, Wang WH, Peng F. Biologics as a novel treatment option for palmoplantar pustulosis: a comprehensive review. Postepy Dermatol Alergol 41: 262-269, 2024.","DOI":"10.5114\/ada.2024.141128"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Terui T, Kobayashi S, Okubo Y, et al. Efficacy and safety of guselkumab in Japanese patients with palmoplantar pustulosis: a phase 3 randomized clinical trial. JAMA Dermatol 155: 1153-1161, 2019.","DOI":"10.1001\/jamadermatol.2019.1394"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Okubo Y, Murakami M, Kobayashi S, et al. Risankizumab in Japanese patients with moderate-to-severe palmoplantar pustulosis: results from the randomized, phase 3 JumPPP study. J Dermatol 52: 593-602, 2025.","DOI":"10.1111\/1346-8138.17659"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Tsuji S, Okubo Y, Kishimoto M, et al. Modified pustulotic arthro-osteitis diagnostic guidance 2022 - Modified Sonozaki criteria secondary publication. Mod Rheumatol 34: 1076-1078, 2024.","DOI":"10.1093\/mr\/roae003"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Bhushan M, Burden AD, McElhone K, James R, Vanhoutte FP, Griffiths CE. Oral liarozole in the treatment of palmoplantar pustular psoriasis: a randomized, double-blind, placebo-controlled study. Br J Dermatol 145: 546-553, 2001.","DOI":"10.1046\/j.1365-2133.2001.04411.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Yamamoto T, Hiraiwa T, Tobita R, et al. Characteristics of Japanese patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis: a multicenter study. Int J Dermatol 59: 441-444, 2020.","DOI":"10.1111\/ijd.14788"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kondo N, Sakai Y, Kakutani R, et al. Clinical characteristics and treatment status of pustulotic arthro-osteitis: a single-center study involving 51 cases. J Dermatol 48: 1724-1730, 2021.","DOI":"10.1111\/1346-8138.16107"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kishimoto M, Taniguchi Y, Tsuji S, et al. SAPHO syndrome and pustulotic arthro-osteitis. Mod Rheumatol 32: 665-674, 2022.","DOI":"10.1093\/mr\/roab103"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Mori Y, Izumiyama T, Okuno H, et al. Assessment of clinical and radiological characteristics of Japanese patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome. Mod Rheumatol 34: 806-812, 2024.","DOI":"10.1093\/mr\/road086"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kahn MF, Khan MA. The SAPHO syndrome. Baillieres Clin Rheumatol 8: 333-362, 1994.","DOI":"10.1016\/S0950-3579(94)80022-7"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Adi\u015fen E, G\u00fcrer MA. Therapeutic options for palmoplantar pustulosis. Clin Exp Dermatol 35: 219-222, 2010.","DOI":"10.1111\/j.1365-2230.2009.03520.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Just A, Adams S, Brinkmeier T, et al. Successful treatment of primary chronic osteomyelitis in SAPHO syndrome with bisphosphonates. J Dtsch Dermatol Ges 6: 657-660, 2008.","DOI":"10.1111\/j.1610-0387.2008.06588.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Tsiogkas SG, Grammatikopoulou MG, Kontouli KM, et al. Efficacy of biologic agents for palmoplantar psoriasis: a systematic review and network meta-analysis. Expert Rev Clin Immunol 19: 1485-1498, 2023.","DOI":"10.1080\/1744666X.2023.2272049"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Krabbe S, \u00d8stergaard M, Pedersen SJ, et al. Canada-Denmark MRI scoring system of the spine in patients with axial spondyloarthritis: updated definitions, scoring rules and inter-reader reliability in a multiple reader setting. RMD Open 5: e001057, 2019.","DOI":"10.1136\/rmdopen-2019-001057"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. McCluskey D, Benzian-Olsson N, Mahil SK, et al. Single-cell analysis implicates T<sub>H<\/sub>17-to-T<sub>H<\/sub>2 cell plasticity in the pathogenesis of palmoplantar pustulosis. J Allergy Clin Immunol 150: 882-893, 2022.","DOI":"10.1016\/j.jaci.2022.04.027"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Yamamoto T, Fukuda K, Morita A, et al. Efficacy of guselkumab in a subpopulation with pustulotic arthro-osteitis through week 52: an exploratory analysis of a phase 3, randomized, double-blind, placebo-controlled study in Japanese patients with palmoplantar pustulosis. J Eur Acad Dermatol Venereol 34: 2318-2329, 2020.","DOI":"10.1111\/jdv.16355"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Pang Y, D&apos;Cunha R, Winzenborg I, Veldman G, Pivorunas V, Wallace K. Risankizumab: mechanism of action, clinical and translational science. Clin Transl Sci 17: e13706, 2024.","DOI":"10.1111\/cts.13706"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/6\/65_5979-25\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:33:53Z","timestamp":1774064033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/6\/65_5979-25\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,15]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.5979-25","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,15]]},"article-number":"5979-25"}}