{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:12:37Z","timestamp":1788581557132,"version":"build-2803163510"},"reference-count":11,"publisher":"Japanese Society of Internal Medicine","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026,9,1]]},"DOI":"10.2169\/internalmedicine.6327-25","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T22:08:02Z","timestamp":1769897282000},"page":"2395-2399","source":"Crossref","is-referenced-by-count":3,"title":["Cytotoxic Lesion of the Corpus Callosum in a Patient with Acute-on-chronic Lithium Toxicity"],"prefix":"10.2169","volume":"65","author":[{"given":"Takeshi","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruki","family":"Kuroshita","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kashima Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosui","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minori","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayano","family":"Notsuyu","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Fushino","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"Tomisawa","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishun","family":"Boku","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Gitlin M. Lithium side effects and toxicity: prevalence and management strategies. Int J Bipolar Disord 4: 27, 2016.","DOI":"10.1186\/s40345-016-0068-y"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Goto T, Ishitobi M, Takahashi T, Higashima M, Wada Y. Reversible splenial lesion related to acute lithium intoxication in a bipolar patient: a case report. J Clin Psychopharmacol 36: 528-529, 2016.","DOI":"10.1097\/JCP.0000000000000544"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ryu HU, Chung JY, Shin B-S, Kang HG. Lithium induced reversible splenial lesion in neuroleptic malignant syndrome like symptoms: two case reports. BMC Neurol 20: 164, 2020.","DOI":"10.1186\/s12883-020-01742-z"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Ono R, Nishiguchi S, Kitagawa I. Lithium intoxication-associated mild encephalitis\/encephalopathy with a reversible splenial lesion: a case report. Bipolar Disord 24: 551-552, 2022.","DOI":"10.1111\/bdi.13242"},{"key":"5","unstructured":"5. Mizouchi N, Ishigame N, Hirose Y, Inoue Y, Sakata Y, Hirose Y. [A case of lithium intoxication with a reversible lesion in the corpus callosum on MRI]. Chudoku Kenkyu (Jpn J Clin Toxicol) 35: 47-49, 2022 (in Japanese)."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Zhou X, Zhang C, Zhou L, Zhou L, Zou Y. Reversible splenial lesion syndrome induced by paracetamol and lithium: a report of two cases and literature review. Cureus 17: e80367, 2025.","DOI":"10.7759\/cureus.80367"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Starkey J, Kobayashi N, Numaguchi Y, Moritani T. Cytotoxic lesions of the corpus callosum that show restricted diffusion: mechanisms, causes, and manifestations. Radiographics 37: 562-576, 2017.","DOI":"10.1148\/rg.2017160085"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Moors S, Nakhostin D, Ilchenko D, et al. Cytotoxic lesions of the corpus callosum: a systematic review. Eur Radiol 34: 4628-4637, 2023.","DOI":"10.1007\/s00330-023-10524-3"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Garcia-Monco JC, Cortina IE, Ferreira E, et al. Reversible splenial lesion syndrome (RESLES): what&apos;s in a name? J Neuroimaging 21: e1-e14, 2011.","DOI":"10.1111\/j.1552-6569.2008.00279.x"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Blaauw J, Meiners LC. The splenium of the corpus callosum: embryology, anatomy, function and imaging with pathophysiological hypothesis. Neuroradiology 62: 563-585, 2020.","DOI":"10.1007\/s00234-019-02357-z"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Sakrajda K, Rybakowski JK. The mechanisms of lithium action: The old and new findings. Pharmaceuticals (Basel) 18: 467, 2025.","DOI":"10.3390\/ph18040467"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/17\/65_6327-25\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:31:11Z","timestamp":1788579071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/17\/65_6327-25\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":11,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.6327-25","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"article-number":"6327-25"}}