{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:17:05Z","timestamp":1783138625979,"version":"3.54.6"},"reference-count":18,"publisher":"Japanese Society of Internal Medicine","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026,7,1]]},"DOI":"10.2169\/internalmedicine.6414-25","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:07:13Z","timestamp":1762985233000},"page":"1786-1793","source":"Crossref","is-referenced-by-count":0,"title":["A Diagnostic Blind Spot in Pseudo-Bartter Syndrome: Aberrant Renin-angiotensin-aldosterone System Activation from Focal Renal Scarring"],"prefix":"10.2169","volume":"65","author":[{"given":"Hirofumi","family":"Makino","sequence":"first","affiliation":[{"name":"Internal Medicine 1, Shimane University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Takedani","sequence":"additional","affiliation":[{"name":"Internal Medicine 1, Shimane University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Ichiro","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Internal Medicine 1, Shimane University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwa","family":"Morita","sequence":"additional","affiliation":[{"name":"Internal Medicine 1, Shimane University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motofumi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Matsue City Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Notsu","sequence":"additional","affiliation":[{"name":"Internal Medicine 1, Shimane University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Kanasaki","sequence":"additional","affiliation":[{"name":"Internal Medicine 1, Shimane University Faculty of Medicine, Japan"},{"name":"Center for Integrated Kidney Research and Advance, Shimane University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Bartter FC, Pronove P, Gill JR Jr., Maccardle RC. Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. Am J Med 33: 811-828, 1962.","DOI":"10.1016\/0002-9343(62)90214-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Konrad M, Nijenhuis T, Ariceta G, et al. Diagnosis and management of Bartter syndrome: executive summary of the consensus and recommendations from the European Rare Kidney Disease Reference Network Working Group for Tubular Disorders. Kidney Int 99: 324-335, 2021.","DOI":"10.1016\/j.kint.2020.10.035"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Komhoff M, Laghmani K. Pathophysiology of antenatal Bartter's syndrome. Curr Opin Nephrol Hypertens 26: 419-425, 2017.","DOI":"10.1097\/MNH.0000000000000346"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Puckett L. Renal and electrolyte complications in eating disorders: a comprehensive review. J Eat Disord 11: 26, 2023.","DOI":"10.1186\/s40337-023-00751-w"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Lee SH, Lee S, Kim H, Kim GH. Pseudo-Gitelman syndrome presenting with hypokalemic metabolic alkalosis and hypocalciuria. Electrolyte Blood Press 21: 72-76, 2023.","DOI":"10.5049\/EBP.2023.21.2.72"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kondo A, Yoshiya K, Sakakibara N, Nagano C, Horinouchi T, Nozu K. A case of pseudo-Bartter\/Gitelman syndrome caused by long-term laxative abuse, leading to end-stage kidney disease. CEN Case Rep 13: 326-329, 2024.","DOI":"10.1007\/s13730-024-00851-9"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Mori T, Chiga M, Fujimaru T, et al. Phenotypic differences of mutation-negative cases in Gitelman syndrome clinically diagnosed in adulthood. Hum Mutat 42: 300-309, 2021.","DOI":"10.1002\/humu.24159"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kono T, Ikeda F, Taniguchi A, et al. Responses of patients with Bartter's syndrome to angiotensin II and related peptides: blunted pressor response before indomethacin, improved afterward. Acta Endocrinol (Copenh) 109: 249-253, 1985.","DOI":"10.1530\/acta.0.1090249"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Shoji M, Kimura T, Ota K, Inoue M, Sato K, Ohta M. Impaired water diuresis in a patient with pseudo-Bartter syndrome: attenuated pressor response to angiotensin II despite normal blood pressure. Endocrinol Jpn 39: 65-71, 1992.","DOI":"10.1507\/endocrj1954.39.65"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Konda R, Orikasa S, Sakai K, Ota S, Kimura N. The distribution of renin containing cells in scarred kidneys. J Urol 156: 1450-1454, 1996.","DOI":"10.1016\/S0022-5347(01)65627-1"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Sequeira L\u00f3pez ML, Pentz ES, Nomasa T, Smithies O, Gomez RA. Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened. Dev Cell 6: 719-728, 2004.","DOI":"10.1016\/S1534-5807(04)00134-0"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Douglas J, Catt KJ. Regulation of angiotensin II receptors in the rat adrenal cortex by dietary electrolytes. J Clin Invest 58: 834-843, 1976.","DOI":"10.1172\/JCI108536"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Wang DH, Qiu J, Hu Z, Du Y. Regulation of type 1 angiotensin II receptor in adrenal gland: role of \u03b1-adrenoreceptor. Hypertension 30: 345-350, 1997.","DOI":"10.1161\/01.HYP.30.3.345"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Seccia TM, Caroccia B, Gomez-Sanchez EP, Gomez-Sanchez CE, Rossi GP. The biology of normal zona glomerulosa and aldosterone-producing adenoma: pathological implications. Endocr Rev 39: 1029-1056, 2018.","DOI":"10.1210\/er.2018-00060"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Matsunoshita N, Nozu K, Shono A, et al. Differential diagnosis of Bartter syndrome, Gitelman syndrome, and pseudo-Bartter\/Gitelman syndrome based on clinical characteristics. Genet Med 18: 180-188, 2016.","DOI":"10.1038\/gim.2015.56"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Jim\u00e9nez ML, Mateos FA, Puig JG, Ramos TH, V\u00e1zquez JO, Barbado FJ. Hyperuricemia as possible diagnostic aid to factitious-Bartter's syndrome. Adv Exp Med Biol 195 Pt A: 351-356, 1986.","DOI":"10.1007\/978-1-4684-5104-7_60"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Mascolo M, McBride J, Mehler PS. Effective medical treatment strategies to help cessation of purging behaviors. Int J Eat Disord 49: 324-330, 2016.","DOI":"10.1002\/eat.22500"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Majd M, Rushton HG. Renal cortical scintigraphy in the diagnosis of acute pyelonephritis. Semin Nucl Med 22: 98-111, 1992.","DOI":"10.1016\/S0001-2998(05)80085-6"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/13\/65_6414-25\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:29:58Z","timestamp":1783135798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/13\/65_6414-25\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":18,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.6414-25","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"article-number":"6414-25"}}