{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T04:09:53Z","timestamp":1746331793916},"reference-count":34,"publisher":"Japanese Society of Internal Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2021,5,15]]},"DOI":"10.2169\/internalmedicine.6468-20","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T22:08:27Z","timestamp":1621030107000},"page":"1601-1605","source":"Crossref","is-referenced-by-count":4,"title":["Aplastic Anemia in a Patient with Cronkhite-Canada Syndrome"],"prefix":"10.2169","volume":"60","author":[{"given":"Keisuke","family":"Kidoguchi","sequence":"first","affiliation":[{"name":"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Kubota","sequence":"additional","affiliation":[{"name":"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan"},{"name":"Department of Transfusion Medicine, Saga University Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Sakata","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruna","family":"Kizuka-Sano","sequence":"additional","affiliation":[{"name":"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyosuke","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ureshino","sequence":"additional","affiliation":[{"name":"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Katsuya","sequence":"additional","affiliation":[{"name":"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Ando","sequence":"additional","affiliation":[{"name":"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Esaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Cronkhite LW Jr., Canada WJ. Generalized gastrointestinal polyposis; an unusual syndrome of polyposis, pigmentation, alopecia and onychotrophia. N Engl J Med 252: 1011-1015, 1955.","DOI":"10.1056\/NEJM195506162522401"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Daniel ES, Ludwig SL, Lewin KJ, Ruprecht RM, Rajacich GM, Schwabe AD. The Cronkhite-Canada syndrome. An analysis of clinical and pathologic features and therapy in 55 patients. Medicine (Baltimore) 61: 293-309, 1982.","DOI":"10.1097\/00005792-198209000-00002"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Watanabe C, Komoto S, Tomita K, et al. Endoscopic and clinical evaluation of treatment and prognosis of Cronkhite-Canada syndrome: a Japanese nationwide survey. J Gastroenterol 51: 327-336, 2016.","DOI":"10.1007\/s00535-015-1107-7"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Ota S, Kasahara A, Tada S, et al. Cronkhite-Canada syndrome showing elevated levels of antinuclear and anticentromere antibody. Clin J Gastroenterol 8: 29-34, 2015.","DOI":"10.1007\/s12328-014-0547-6"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Sweetser S, Ahlquist DA, Osborn NK, et al. Clinicopathologic features and treatment outcomes in Cronkhite-Canada syndrome: support for autoimmunity. Dig Dis Sci 57: 496-502, 2012.","DOI":"10.1007\/s10620-011-1874-9"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Nakao S, Feng X, Sugimori C. Immune pathophysiology of aplastic anemia. Int J Hematol 82: 196-200, 2005.","DOI":"10.1532\/IJH97.05116"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia. Blood 108: 2509-2519, 2006.","DOI":"10.1182\/blood-2006-03-010777"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Schulte S, Kutting F, Mertens J, et al. Case report of patient with a Cronkhite-Canada syndrome: sustained remission after treatment with corticosteroids and mesalazine. BMC Gastroenterol 19: 36, 2019.","DOI":"10.1186\/s12876-019-0944-x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Yamakawa K, Yoshino T, Watanabe K, et al. Effectiveness of cyclosporine as a treatment for steroid-resistant Cronkhite-Canada syndrome; two case reports. BMC Gastroenterol 16: 123, 2016.","DOI":"10.1186\/s12876-016-0541-1"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Mao EJ, Hyder SM, DeNucci TD, Fine S. A successful steroid-sparing approach in Cronkhite-Canada syndrome. ACG Case Rep J 6: 1-4, 2019.","DOI":"10.14309\/crj.0000000000000055"},{"key":"11","unstructured":"11. Otsubo H, Kaito K, Sekita T, Shimada T, Kobayashi M, Hosoya T. Mesalazine-associated severe aplastic anemia successfully treated with antithymocyte globulin, cyclosporine and granulocyte colony-stimulating factor. Int J Hematol 68: 445-448, 1998."},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Wyatt S, Joyner MV, Daneshmend TK. Filgrastim for mesalazine-associated neutropenia. Lancet 341: 1476, 1993.","DOI":"10.1016\/0140-6736(93)90918-7"},{"key":"13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0140-6736(94)91495-8","volume":"343","author":"ZH Abboudi","year":"1994","unstructured":"13. Abboudi ZH, Marsh JC, Smith-Laing G, Gordon-Smith EC. Fatal aplastic anaemia after mesalazine. Lancet 343: 542, 1994.","journal-title":"The Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Laidlaw ST, Reilly JT. Antilymphocyte globulin for mesalazine-associated aplastic anaemia. Lancet 343: 981-982, 1994.","DOI":"10.1016\/S0140-6736(94)90108-2"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Wiesen A, Wiesen J, Limaye S, Kaushik N. Mesalazine-induced aplastic anemia. Am J Gastroenterol 104: 1063, 2009.","DOI":"10.1038\/ajg.2008.164"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Daneshmend TK. Mesalazine-associated thrombocytopenia. Lancet 337: 1297-1298, 1991.","DOI":"10.1016\/0140-6736(91)92973-6"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Young NS. Aplastic anemia. N Engl J Med 379: 1643-1656, 2018.","DOI":"10.1056\/NEJMra1413485"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18. Sugimori C, Chuhjo T, Feng X, et al. Minor population of CD55<sup>-<\/sup>CD59<sup>-<\/sup> blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia. Blood 107: 1308-1314, 2006.","DOI":"10.1182\/blood-2005-06-2485"},{"key":"19","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1182\/blood.V85.5.1354.bloodjournal8551354","volume":"85","author":"A Griscelli-Bennaceur","year":"1995","unstructured":"19. Griscelli-Bennaceur A, Gluckman E, Scrobohaci ML, et al. Aplastic anemia and paroxysmal nocturnal hemoglobinuria: search for a pathogenetic link. Blood 85: 1354-63, 1995.","journal-title":"Blood","ISSN":"http:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Nakagawa N, Maruyama H, Zaimoku Y, et al. Evidence for a common immune pathophysiology in acquired aplastic anemia and ulcerative colitis. Blood 126: 2418, 2015.","DOI":"10.1182\/blood.V126.23.2418.2418"},{"key":"21","unstructured":"21. Shimada T, Maeda T, Ishikawa M, et al. [Aplastic anemia complicated with ulcerative colitis]. Rinsho Ketsueki (Jpn J Clin Hematol) 53: 224-228, 2012 (in Japanese, Abstract in English)."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Dendrou CA, Petersen J, Rossjohn J, Fugger L. HLA variation and disease. Nat Rev Immunol 18: 325-339, 2018.","DOI":"10.1038\/nri.2017.143"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Gough SC, Simmonds MJ. The HLA region and autoimmune disease: associations and mechanisms of action. Curr Genomics 8: 453-465, 2007.","DOI":"10.2174\/138920207783591690"},{"key":"24","unstructured":"24. Kular L, Liu Y, Ruhrmann S, et al. DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis. Nat Commun 9: 2397, 2018."},{"key":"25","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1182\/blood.V84.3.923.923","volume":"84","author":"SD Nimer","year":"1994","unstructured":"25. Nimer SD, Ireland P, Meshkinpour A, Frane M. An increased HLA DR2 frequency is seen in aplastic anemia patients. Blood 84: 923-927, 1994.","journal-title":"Blood","ISSN":"http:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Dhaliwal JS, Wong L, Kamaluddin MA, Yin LY, Murad S. Susceptibility to aplastic anemia is associated with HLA-DRB1*1501 in an aboriginal population in Sabah, Malaysia. Hum Immunol 72: 889-892, 2011.","DOI":"10.1016\/j.humimm.2011.06.013"},{"key":"27","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1182\/blood.V84.12.4257.bloodjournal84124257","volume":"84","author":"S Nakao","year":"1994","unstructured":"27. Nakao S, Takamatsu H, Chuhjo T, et al. Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporine-dependent aplastic anemia. Blood 84: 4257-4261, 1994.","journal-title":"Blood","ISSN":"http:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Sugimori C, Yamazaki H, Feng X, et al. Roles of DRB1*1501 and DRB1*1502 in the pathogenesis of aplastic anemia. Exp Hematol 35: 13-20, 2007.","DOI":"10.1016\/j.exphem.2006.09.002"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Futami S, Aoyama N, Honsako Y, et al. HLA-DRB1*1502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression. Dig Dis Sci 40: 814-818, 1995.","DOI":"10.1007\/BF02064985"},{"key":"30","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0016-5085(80)90254-1","volume":"79","author":"M Ali","year":"1980","unstructured":"30. Ali M, Weinstein J, Biempica L, Halpern A, Das KM. Cronkhite-Canada syndrome: report of a case with bacteriologic, immunologic, and electron microscopic studies. Gastroenterology 79: 731-736, 1980.","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Nemade NL, Shukla UB, Wagholikar GD. Cronkhite Canada syndrome complicated by pulmonary embolism - a case report. Int J Surg Case Rep 30: 17-22, 2017.","DOI":"10.1016\/j.ijscr.2016.11.020"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Takeuchi Y, Yoshikawa M, Tsukamoto N, Shiroi A, Hoshida Y, Enomoto Y, et al. Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis. J Gastroenterol 38: 791-795, 2003.","DOI":"10.1007\/s00535-002-1148-6"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Hsu YQ, Loke SL. Cronkhite-Canada syndrome. Gastrointest Endosc 57: 917, 2003.","DOI":"10.1016\/S0016-5107(03)70030-3"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Johannesdottir SA, Horv\u00e1th-Puh\u00f3 E, Dekkers OM, et al. Use of glucocorticoids and risk of venous thromboembolism: a nationwide population-based case-control study. JAMA Intern Med 173: 743-752, 2013.","DOI":"10.1001\/jamainternmed.2013.122"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/60\/10\/60_6468-20\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T03:51:16Z","timestamp":1621050676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/60\/10\/60_6468-20\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,15]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.6468-20","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,15]]}}}