{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:42:45Z","timestamp":1792212165286,"version":"4.4.0"},"reference-count":27,"publisher":"Japanese Society of Internal Medicine","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026,10,15]]},"DOI":"10.2169\/internalmedicine.6521-25","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T22:10:35Z","timestamp":1772489435000},"page":"2671-2679","source":"Crossref","is-referenced-by-count":2,"title":["The Safety and Efficacy of a Transbronchial Lung Cryobiopsy Using a 1.7-mm Cryoprobe in Older Adult Patients with Suspected Interstitial Lung Disease: A Single-center, Retrospective, Observational Study"],"prefix":"10.2169","volume":"65","author":[{"given":"Miho","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, NHO Okayama Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Takigawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Okayama Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Okayama Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyoshi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Okayama Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzuka","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Okayama Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Okayama Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Okayama Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Okayama Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Okayama Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Okayama Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Lachowicz JA, Smallwood NE, Prasad JD, et al. A systematic review of procedural and sampling techniques for cryobiopsy in interstitial lung disease. Eur Respir Rev 33: 240035, 2024.","DOI":"10.1183\/16000617.0035-2024"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kondoh Y, Ito T, Saito K, Bao H, Sakamoto W. Progressive pulmonary fibrosis (PPF): estimation of incidence and treatment rates in Japan using a claims database. Respir Investig 62: 702-709, 2024.","DOI":"10.1016\/j.resinv.2024.05.005"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Awano N, Jo T, Izumo T, et al. Safety of transbronchial lung cryobiopsy compared to transbronchial forceps biopsy in patients with diffuse lung disease: an observational study using a national database in Japan. Respir Investig 62: 844-849, 2024.","DOI":"10.1016\/j.resinv.2024.07.010"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Honda K, Saraya T, Ishii H. A real-world prognosis in idiopathic pulmonary fibrosis: a special reference to the role of antifibrotic agents for the elderly. J Clin Med 12: 3564, 2023.","DOI":"10.3390\/jcm12103564"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Rodrigues I, Est\u00eav\u00e3o Gomes R, Coutinho LM, et al. Diagnostic yield and safety of transbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases: a systematic review and meta-analysis. Eur Respir Rev 31: 210280, 2022.","DOI":"10.1183\/16000617.0280-2021"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kheir F, Uribe Becerra JP, Bissell B, et al. Transbronchial lung cryobiopsy in patients with interstitial lung disease: a systematic review. Ann Am Thorac Soc 19: 1193-1202, 2022.","DOI":"10.1513\/AnnalsATS.202102-198OC"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Raghu G, Remy-Jardin M, Richeldi L, et al. Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an official ATS\/ERS\/JRS\/ALAT clinical practice guideline. Am J Respir Crit Care Med 205: e18-e47, 2022.","DOI":"10.1164\/rccm.202202-0399ST"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Inomata M, Kuse N, Awano N, et al. Prospective multicentre study on the safety and utility of transbronchial lung cryobiopsy with endobronchial balloon. ERJ Open Res 6: 00008-2020, 2020.","DOI":"10.1183\/23120541.00008-2020"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Patterson KC, Shah RJ, Porteous MK, et al. Interstitial lung disease in the elderly. Chest 151: 838-844, 2017.","DOI":"10.1016\/j.chest.2016.11.003"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Du Rand IA, Blaikley J, Booton R, et al. British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE. Thorax 68 (Suppl 1): i1-i44, 2013.","DOI":"10.1136\/thoraxjnl-2013-203618"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Echevarria-Uraga JJ, P\u00e9rez-Izquierdo J, Garc\u00eda-Garai N, et al. Usefulness of an angioplasty balloon as selective bronchial blockade device after transbronchial cryobiopsy. Respirology 21: 1094-1099, 2016.","DOI":"10.1111\/resp.12827"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Oki M, Saka H, Kogure Y, et al. Thin bronchoscopic cryobiopsy using a nasobronchial tube. BMC Pulm Med 22: 361, 2022.","DOI":"10.1186\/s12890-022-02166-w"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Nakai T, Watanabe T, Kaimi Y, et al. Safety profile and risk factors for bleeding in transbronchial cryobiopsy using a two-scope technique for peripheral pulmonary lesions. BMC Pulm Med 22: 20, 2022.","DOI":"10.1186\/s12890-021-01817-8"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Zaizen Y, Umemoto S, Matama G, et al. Obesity may be a risk factor for transbronchial lung cryobiopsy-related adverse events in Japanese patients with interstitial lung disease. Respir Investig 62: 102-106, 2024.","DOI":"10.1016\/j.resinv.2023.11.002"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kuse N, Inomata M, Awano N, et al. Management and utility of transbronchial lung cryobiopsy in Japan. Respir Investig 57: 245-251, 2019.","DOI":"10.1016\/j.resinv.2018.12.011"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kaburaki S, Tanaka T, Kamio K, Tanaka Y, Kasahara K, Seike M. Transbronchial lung cryobiopsy for interstitial lung disease: early experience, learning curve, and the impact of sedation on complication rates at a single centre in Japan. BMC Pulm Med 24: 540, 2024.","DOI":"10.1186\/s12890-024-03359-1"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Mononen M, Saari E, Hasala H, et al. Risk factors of clinically significant complications in transbronchial lung cryobiopsy: a prospective multi-center study. Respir Med 200: 106922, 2022.","DOI":"10.1016\/j.rmed.2022.106922"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Yu M, Xu X, Xin X, et al. Transbronchial lung cryobiopsy for diagnosing interstitial lung disease: a cross-sectional, comparative study. Eur J Med Res 30: 171, 2025.","DOI":"10.1186\/s40001-025-02435-4"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Ravaglia C, Wells AU, Tomassetti S, et al. Diagnostic yield and risk\/benefit analysis of trans-bronchial lung cryobiopsy in diffuse parenchymal lung diseases: a large cohort of 699 patients. BMC Pulm Med 19: 16, 2019.","DOI":"10.1186\/s12890-019-0780-3"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Niwa T, Kondo K, Sakurai T, et al. Safety and learning curve for transbronchial lung cryobiopsy. ERJ Open Res 54: PA1323, 2019.","DOI":"10.1183\/13993003.congress-2019.PA1323"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Ravaglia C, Wells AU, Tomassetti S, et al. Transbronchial lung cryobiopsy in diffuse parenchymal lung disease: comparison between biopsy from 1 segment and biopsy from 2 segments-diagnostic yield and complications. Respiration 93: 285-292, 2017.","DOI":"10.1159\/000456671"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Takigawa Y, Watanabe H, Sato K, et al. A case of lung metastasis of breast cancer diagnosed using ultrathin bronchoscopic cryobiopsy with a &quot;tube-wedging method&quot; . Respir Endosc 2: 32-35, 2024.","DOI":"10.58585\/respend.2023-0036"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Yamatsuta K, Okachi S, Hasegawa S, et al. Safety and efficacy of transbronchial cryobiopsy for elderly lung cancer patients. BMC Pulm Med 24: 632, 2024.","DOI":"10.1186\/s12890-024-03456-1"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Niwa H, Oki M, Ishii Y, et al. Safety and efficacy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for patients aged 80 years and older. Thorac Cancer 13: 1783-1787, 2022.","DOI":"10.1111\/1759-7714.14454"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Iwasaki M, Uchimura K, Furuse H, Imabayashi T, Tsuchida T, Matsumoto Y. Safety of cryobiopsy for peripheral pulmonary lesions in older people. Respir Investig 63: 749-754, 2025.","DOI":"10.1016\/j.resinv.2025.06.009"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Evison M, Crosbie PA, Martin J, et al. EBUS-TBNA in elderly patients with lung cancer: safety and performance outcomes. J Thorac Oncol 9: 370-376, 2014.","DOI":"10.1097\/JTO.0000000000000085"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Olgun Y, \u0131ld\u0131zeli \u015e, Tufan A, Bozkurtlar E, et al. Endobronchial ultrasound transbronchial needle aspiration in elderly patients: safety and performance outcomes EBUS-TBNA in elderly. Aging Male 23: 507-512, 2020.","DOI":"10.1080\/13685538.2018.1538337"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/20\/65_6521-25\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:16:32Z","timestamp":1792210592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/20\/65_6521-25\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":27,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.6521-25","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"article-number":"6521-25"}}