{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:57:01Z","timestamp":1790855821145,"version":"4.1.0"},"reference-count":17,"publisher":"Japanese Society of Internal Medicine","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2021]]},"DOI":"10.2169\/internalmedicine.6572-20","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T22:07:35Z","timestamp":1612735655000},"source":"Crossref","is-referenced-by-count":2,"title":["Composite Epstein-Barr Virus-associated T-lymphoblastic and Peripheral T-cell Lymphomas: A Clonal Study"],"prefix":"10.2169","author":[{"given":"Hiroki","family":"Hosoi","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology, Wakayama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Mushino","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Wakayama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kurume University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodai","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Wakayama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Wakayama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-Ichi","family":"Imadome","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine for Infections, National Center for Child Health and Development, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kurume University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sonoki","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Wakayama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Young LS, Yap LF, Murray PG. Epstein-Barr virus: more than 50 years old and still providing surprises. Nat Rev Cancer 16: 789-802, 2016."},{"key":"2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2042-4280-2-8","volume":"2","author":"CP Fox","year":"2011","unstructured":"2. Fox CP, Shannon-Lowe C, Rowe M. Deciphering the role of Epstein-Barr virus in the pathogenesis of T and NK cell lymphoproliferations. Herpesviridae 2: 8, 2011.","journal-title":"Herpesviridae","ISSN":"https:\/\/id.crossref.org\/issn\/2042-4280","issn-type":"print"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Hutt-Fletcher LM. Epstein-Barr virus entry. J Virol 81: 7825-7832, 2007.","DOI":"10.1128\/JVI.00445-07"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Braun M, Melchers I, Peter HH, Illges H. Human B and T lymphocytes have similar amounts of CD21 mRNA, but differ in surface expression of the CD21 glycoprotein. Int Immunol 10: 1197-1202, 1998.","DOI":"10.1093\/intimm\/10.8.1197"},{"key":"5","unstructured":"5. Castillo JJ, Reagan JL, Bishop KD, Apor E. Viral lymphomagenesis: from pathophysiology to the rationale for novel therapies. Br J Haematol 165: 300-315, 2014."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Hosoi H, Imadome KI, Tamura S, et al. An Epstein-Barr virus susceptible immature T-cell line, WILL4, established from a patient with T-lymphoblastic lymphoma bearing CD21 and a clonal EBV genome. Leuk Res 55: 1-5, 2017.","DOI":"10.1016\/j.leukres.2017.01.022"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Miki T, Kawamata N, Arai A, et al. Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias. Blood 83: 217-222, 1994.","DOI":"10.1182\/blood.V83.1.217.217"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Langerak AW, Moreau E, van Gastel-Mol EJ, van der Burg M, van Dongen JJ. Detection of clonal EBV episomes in lymphoproliferations as a diagnostic tool. Leukemia 16: 1572-1573, 2002.","DOI":"10.1038\/sj.leu.2402519"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17: 2257-2317, 2003.","DOI":"10.1038\/sj.leu.2403202"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kuppers R, Duhrsen U, Hansmann ML. Pathogenesis, diagnosis, and treatment of composite lymphomas. Lancet Oncol 15: e435-e446, 2014.","DOI":"10.1016\/S1470-2045(14)70153-6"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Suefuji N, Niino D, Arakawa F, et al. Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas. Pathol Int 62: 690-698, 2012.","DOI":"10.1111\/j.1440-1827.2012.02858.x"},{"key":"12","unstructured":"12. Niino D, Ohsaki K, Arakawa F, et al. Composite T lymphoblastic leukemia\/lymphoma and diffuse large B-cell lymphoma: case report. Pathol Int 61: 363-368, 2011."},{"key":"13","unstructured":"13. Guan C, Li J, Xu P, Ouyang J, Chen B. Composite primary breast diffuse large B-cell lymphoma and T lymphoblastic leukemia\/lymphoma: report of a case and review of literature. Int J Clin Exp Pathol 8: 9629-9637, 2015."},{"key":"14","unstructured":"14. Markow M, Mirza AS, Perez L, et al. Transformation of T-Cell Acute Lymphoblastic Lymphoma to Peripheral T-Cell Lymphoma: A Report of Two Cases. Case Rep Hematol 2018: 9191582, 2018."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Rushton CK, Arthur SE, Alcaide M, et al. Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma. Blood Adv 4: 2886-2898, 2020.","DOI":"10.1182\/bloodadvances.2020001696"},{"key":"16","unstructured":"16. Marusyk A, Janiszewska M, Polyak K. Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance. Cancer Cell 37: 471-484, 2020."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Fischer EM, Mouhoub A, Maillet F, et al. Expression of CD21 is developmentally regulated during thymic maturation of human T lymphocytes. Int Immunol 11: 1841-1849, 1999.","DOI":"10.1093\/intimm\/11.11.1841"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_6572-20\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T03:56:40Z","timestamp":1613188600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_6572-20\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":17,"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.6572-20","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}