{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:17:05Z","timestamp":1788617825682,"version":"build-2803163510"},"reference-count":21,"publisher":"Japanese Society of Internal Medicine","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026,8,15]]},"DOI":"10.2169\/internalmedicine.6643-25","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T22:08:22Z","timestamp":1768428502000},"page":"2182-2189","source":"Crossref","is-referenced-by-count":1,"title":["A Prospective Observational Study of AUDIT-based Risk Stratification and Drinking Guidance Provided by Hepatologists in Patients with Alcoholic Liver Disease"],"prefix":"10.2169","volume":"65","author":[{"given":"Nao","family":"Nomura","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Uojima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Japan"},{"name":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahumi","family":"Asakura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Internal Medicine, Kitasato University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enami","family":"Sawayama","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Internal Medicine, Kitasato University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reina","family":"Dezumi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Internal Medicine, Kitasato University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junki","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichiro","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Inada","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Internal Medicine, Kitasato University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Kusano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Enomoto H, Ueno Y, Hiasa Y, et al. Transition in the etiology of liver cirrhosis in Japan: a nationwide survey. J Gastroenterol 55: 353-362, 2020.","DOI":"10.1007\/s00535-019-01645-y"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Takahashi H, Ono M, Hyogo H, et al. Biphasic effect of alcohol intake on the development of fatty liver disease. J Gastroenterol 50: 1114-1123, 2015.","DOI":"10.1007\/s00535-015-1058-z"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Toshikuni N, Tsutsumi M, Arisawa T. Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease. World J Gastroenterol 14: 8393-8406, 2014.","DOI":"10.3748\/wjg.v20.i26.8393"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4. O&apos;Shea RS, Dasarathy S, McCullough AJ. Practice Guideline Committee of the American Association for the Study of Liver Diseases, Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease. Hepatology 51: 307-328, 2010.","DOI":"10.1002\/hep.23258"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Osna NA, Donohue TM Jr, Kharbanda KK. Alcoholic liver disease: pathogenesis and current management. Alcohol Res 38: 147-161, 2017.","DOI":"10.35946\/arcr.v38.2.01"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH. ACG clinical guideline: alcoholic liver disease. Am J Gastroenterol 113: 175-194, 2018.","DOI":"10.1038\/ajg.2017.469"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Stickel F, Datz C, Hampe J, Bataller R. Pathophysiology and management of alcoholic liver disease: update 2016. Gut Liver 11: 173-188, 2017.","DOI":"10.5009\/gnl16477"},{"key":"8","unstructured":"8. Horie Y, Ebinuma H, Kikuchi M, Lamao Takanori. Current status of alcoholic liver disease in Japan and therapeutic strategy. Nihon Aruk\u014dru Yakubutsu Igakkai Zasshi (Jpn J Alcohl Stud Drug Depend) 51: 71-90, 2016."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Kawamura Y, Arase Y, Ikeda K, et al. Effects of alcohol consumption on hepatocarcinogenesis in Japanese patients with fatty liver disease. Clin Gastroenterol Hepatol 14: 597-605, 2016.","DOI":"10.1016\/j.cgh.2015.11.019"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Kawada T, Inagaki H, Kuratomi Y. The alcohol use disorders identification test: reliability study of the Japanese version. Alcohol 45: 205-207, 2011.","DOI":"10.1016\/j.alcohol.2010.08.012"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Taguchi Y, Takei Y, Sasai R, Murteira S. Awareness and treatment of alcohol dependence in Japan: results from internet-based surveys in persons, family, physicians and society. Alcohol Alcohol 49: 439-446, 2014.","DOI":"10.1093\/alcalc\/agu025"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Starosta AN, Leeman RF, Volpicelli JR. The BRENDA model: integrating psychosocial treatment and pharmacotherapy for the treatment of alcohol use disorders. J Psychiatr Pract 12: 80-89, 2006.","DOI":"10.1097\/00131746-200603000-00003"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Karhuvaara S, Simojoki K, Virta A, et al. Targeted nalmefene with simple medical management in the treatment of heavy drinkers: a randomized double-blind placebo-controlled multicenter study. Alcohol Clin Exp Res 31: 1179-1187, 2007.","DOI":"10.1111\/j.1530-0277.2007.00401.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Miyata H, Takahashi M, Murai Y, et al. Nalmefene in alcohol-dependent patients with a high drinking risk: randomized controlled trial. Psychiatry Clin Neurosci 73: 697-706, 2019.","DOI":"10.1111\/pcn.12914"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Mann K, Aubin HJ, Witkiewitz K. Reduced drinking in alcohol dependence treatment, what is the evidence? Eur Addict Res 23: 219-230, 2017.","DOI":"10.1159\/000481348"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Hosseini N, Shor J, Szabo G. Alcoholic hepatitis: a review. Alcohol Alcohol 54: 408-416, 2019.","DOI":"10.1093\/alcalc\/agz036"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Lee BP, Vittinghoff E, Dodge JL, Cullaro G, Terrault NA. National trends and long-term outcomes of liver transplant for alcohol-associated liver disease in the United States. JAMA Intern Med 179: 340-348, 2019.","DOI":"10.1001\/jamainternmed.2018.6536"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Akbar M, Egli M, Cho YE, Song BJ, Noronha A. Medications for alcohol use disorders: an overview. Pharmacol Ther 185: 64-85, 2018.","DOI":"10.1016\/j.pharmthera.2017.11.007"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J. Portal hypertensive bleeding in cirrhosis: risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the Study of Liver Diseases. Hepatology 65: 310-335, 2017.","DOI":"10.1002\/hep.28906"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Lewis JH, Stine JG. Review article: prescribing medications in patients with cirrhosis - a practical guide. Aliment Pharmacol Ther 37: 1132-1156, 2013.","DOI":"10.1111\/apt.12324"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Jophlin LL, Singal AK, Bataller R, et al. ACG Clinical Guideline: Alcohol-Associated Liver Disease. Am J Gastroenterol 119: 30-54, 2024.","DOI":"10.14309\/ajg.0000000000002572"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/16\/65_6643-25\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T04:11:44Z","timestamp":1786767104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/16\/65_6643-25\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,15]]},"references-count":21,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.6643-25","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,15]]},"article-number":"6643-25"}}