{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:12:25Z","timestamp":1781968345389,"version":"3.54.5"},"reference-count":34,"publisher":"Japanese Society of Internal Medicine","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026]]},"DOI":"10.2169\/internalmedicine.6789-25","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:10:27Z","timestamp":1774303827000},"source":"Crossref","is-referenced-by-count":2,"title":["Anaphylaxis and Fulminant Disseminated Intravascular Coagulation Due to Loxoprofen"],"prefix":"10.2169","author":[{"given":"Miyuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Community-Based Co-Creative Hida-Takayama Health Professions Education, Gifu University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Isaji","sequence":"additional","affiliation":[{"name":"Departments of Hematology, Aichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Departments of Clinical Laboratory, Aichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Takami","sequence":"additional","affiliation":[{"name":"Departments of Hematology, Aichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Departments of Clinical Laboratory, Aichi Medical University, Japan"},{"name":"Departments of Transfusion Medicine, Aichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Quinones-Lombrana A, Li N, Del Solar V, Atilla-Gokcumen GE, Blanco JG. CBR1 rs9024 genotype status impacts the bioactivation of loxoprofen in human liver. Biopharm Drug Dispos 39: 315-318, 2018.","DOI":"10.1002\/bdd.2135"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Muraro A, Worm M, Alviani C, et al. EAACI guidelines: Anaphylaxis (2021 update). Allergy 77: 357-377, 2022.","DOI":"10.1111\/all.15032"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Jares EJ, Cardona V, Gomez RM, et al. Latin American anaphylaxis registry. World Allergy Organ J 16: 100748, 2023.","DOI":"10.1016\/j.waojou.2023.100748"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Fontaine C, Bousquet PJ, Demoly P. Anaphylactic shock caused by a selective allergy to celecoxib, with no allergy to rofecoxib or sulfamethoxazole. J Allergy Clin Immunol 115: 633-634, 2005.","DOI":"10.1016\/j.jaci.2004.10.045"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Schneider F, Meziani F, Chartier C, Alt M, Jaeger A. Fatal allergic vasculitis associated with celecoxib. Lancet 359: 852-853, 2002.","DOI":"10.1016\/S0140-6736(02)07922-9"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Chamberlin KW, Silverman AR. Celecoxib-associated anaphylaxis. Ann Pharmacother 43: 777-781, 2009.","DOI":"10.1345\/aph.1L593"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Dux S, Groslop I, Garty M, Rosenfeld JB. Anaphylactic shock induced by diclofenac. Br Med J (Clin Res Ed) 286: 1861, 1983.","DOI":"10.1136\/bmj.286.6381.1861"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Colak S, Gunes H, Afacan MA, et al. Anaphylaxis after intramuscular injection of diclofenac sodium. Am J Emerg Med 32: 815 e811-815 e812, 2014.","DOI":"10.1016\/j.ajem.2013.12.049"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Sipahi Cimen S, Yucel E, Suleyman A, et al. Hypersensitivity to Ibuprofen: Real-Life Experience in Children with History of Suspected Immediate Reactions. Int Arch Allergy Immunol 184: 33-42, 2023.","DOI":"10.1159\/000526981"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Silva MIT, Cosme J, Lorenzo C, et al. Hypersensitivity to non-steroidal anti-inflammatory drugs on a pediatric Portuguese cohort. Eur Ann Allergy Clin Immunol 57: 77-82, 2025.","DOI":"10.23822\/EurAnnACI.1764-1489.299"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30: 239-245, 1981.","DOI":"10.1038\/clpt.1981.154"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Rafei H, Nassereddine S, Garcia IF. Disseminated intravascular coagulation-like reaction following rituximab infusion. BMJ Case Rep 2017: 2017.","DOI":"10.1136\/bcr-2016-218443"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Hashimoto M, Nakayama T, Fujimoto S, et al. Disseminated intravascular coagulation induced by pazopanib following combination therapy of nivolumab plus ipilimumab in a patient with metastatic renal cell carcinoma. Anticancer Drugs 33: e818-e821, 2022.","DOI":"10.1097\/CAD.0000000000001230"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Komatsu S, Horimoto K, Kato J, et al. Disseminated intravascular coagulation induced by the combination therapy of encorafenib and binimetinib in a melanoma case. J Dermatol 51: e218-e219, 2024.","DOI":"10.1111\/1346-8138.17124"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. Ip M, Cheng KP, Cheung WC. Disseminated intravascular coagulopathy associated with rifampicin. Tubercle 72: 291-293, 1991.","DOI":"10.1016\/0041-3879(91)90056-X"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Havey TC, Cserti-Gazdewich C, Sholzberg M, Keystone JS, Gold WL. Recurrent disseminated intravascular coagulation caused by intermittent dosing of rifampin. Am J Trop Med Hyg 86: 264-267, 2012.","DOI":"10.4269\/ajtmh.2012.11-0598"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Chen G, He JQ. Rifampicin-induced disseminated intravascular coagulation in pulmonary tuberculosis treatment: A case report and literature review. Medicine (Baltimore) 96: e6135, 2017.","DOI":"10.1097\/MD.0000000000006135"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Vucic D, Cvitkusic-Lukenda K, Dunder I, Gabaldo K, Knezevic-Pravecek M, Miskic B. Diagnostic complexity of rifampicin-induced coagulopathy in a patient with spontaneous muscle bleeding: A case report. Medicine (Baltimore) 100: e26234, 2021.","DOI":"10.1097\/MD.0000000000026234"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Sousa G, Carreiro A, Duarte P. Rifampicin-induced disseminated intravascular coagulation: An antibody-mediated side effect. Pulmonology 27: 269-272, 2021.","DOI":"10.1016\/j.pulmoe.2020.04.006"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Fukushima N, Kamachi K, Sato T, Ishii K, Tomimasu R, Miyahara M. Anaphylaxis and Severe Disseminated Intravascular Coagulation Due to Remdesivir. Intern Med 63: 873-876, 2024.","DOI":"10.2169\/internalmedicine.2994-23"},{"key":"21","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1365-2249.1995.tb03711.x","volume":"100","author":"IH Choi","year":"1995","unstructured":"21. Choi IH, Ha TY, Lee DG, et al. Occurrence of disseminated intravascular coagulation (DIC) in active systemic anaphylaxis: role of platelet-activating factor. Clin Exp Immunol 100: 390-394, 1995.","journal-title":"Clinical & Experimental Immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Wahid HH, Anahar FN, Isahak NH, et al. Role of Platelet Activating Factor as a Mediator of Inflammatory Diseases and Preterm Delivery. Am J Pathol 194: 862-878, 2024.","DOI":"10.1016\/j.ajpath.2024.01.018"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Stafforini DM, Satoh K, Atkinson DL, et al. Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase. J Clin Invest 97: 2784-2791, 1996.","DOI":"10.1172\/JCI118733"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Stafforini DM, Numao T, Tsodikov A, et al. Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma. J Clin Invest 103: 989-997, 1999.","DOI":"10.1172\/JCI5574"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Miwa M, Miyake T, Yamanaka T, et al. Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children. J Clin Invest 82: 1983-1991, 1988.","DOI":"10.1172\/JCI113818"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Gomes ER, Brockow K, Kuyucu S, et al. Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group. Allergy 71: 149-161, 2016.","DOI":"10.1111\/all.12774"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Kidon M, Blanca-Lopez N, Gomes E, et al. EAACI\/ENDA Position Paper: Diagnosis and management of hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) in children and adolescents. Pediatr Allergy Immunol 29: 469-480, 2018.","DOI":"10.1111\/pai.12915"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Cavkaytar O, du Toit G, Caimmi D. Characteristics of NSAID-induced hypersensitivity reactions in childhood. Pediatr Allergy Immunol 30: 25-35, 2019.","DOI":"10.1111\/pai.12980"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Atanaskovic-Markovic M, Gomes E, Cernadas JR, et al. Diagnosis and management of drug-induced anaphylaxis in children: An EAACI position paper. Pediatr Allergy Immunol 30: 269-276, 2019.","DOI":"10.1111\/pai.13034"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Wang X, Yang A, Huang S, et al. Novel p.C252G and p.C280X mutations in the epidermal growth factor-1 domain of thrombomodulin lead to a thrombosis-bleeding syndrome. J Thromb Haemost 23: 2722-2735, 2025.","DOI":"10.1016\/j.jtha.2025.05.014"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Delvaeye M, Noris M, De Vriese A, et al. Thrombomodulin mutations in atypical hemolytic-uremic syndrome. N Engl J Med 361: 345-357, 2009.","DOI":"10.1056\/NEJMoa0810739"},{"key":"32","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1182\/blood.V85.2.330.330","volume":"85","author":"AK Ohlin","year":"1995","unstructured":"32. Ohlin AK, Marlar RA. The first mutation identified in the thrombomodulin gene in a 45-year-old man presenting with thromboembolic disease. Blood 85: 330-336, 1995.","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Norlund L, Zoller B, Ohlin AK. A novel thrombomodulin gene mutation in a patient suffering from sagittal sinus thrombosis. Thromb Haemost 78: 1164-1166, 1997.","DOI":"10.1055\/s-0038-1657708"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Tang L, Wang HF, Lu X, et al. Common genetic risk factors for venous thrombosis in the Chinese population. Am J Hum Genet 92: 177-187, 2013.","DOI":"10.1016\/j.ajhg.2012.12.013"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_6789-25\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:24:48Z","timestamp":1774668288000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_6789-25\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":34,"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.6789-25","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"6789-25"}}