{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:55:15Z","timestamp":1790999715696,"version":"4.1.0"},"reference-count":40,"publisher":"Japanese Society of Internal Medicine","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026,10,1]]},"DOI":"10.2169\/internalmedicine.6849-25","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:09:38Z","timestamp":1771884578000},"page":"2558-2565","source":"Crossref","is-referenced-by-count":0,"title":["Hepatocellular Carcinoma Associated with Hepatic Sarcoidosis and Budd-Chiari Syndrome: A Case Report and Review of the Literature"],"prefix":"10.2169","volume":"65","author":[{"given":"Yuta","family":"Minami","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Shinshu University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanobu","family":"Iwadare","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Shinshu University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuma","family":"Kamijo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Shinshu University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kurozumi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Radiology, Shinshu University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Shinshu University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Iwaya","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Shinshu University School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takefumi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Shinshu University School of Medicine, Japan"},{"name":"Consultation Center for Liver Diseases, Shinshu University Hospital, Japan"},{"name":"Institute for Biomedical Sciences, Research Cluster for Social Implementation, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Crouser ED, Maier LA, Wilson KC, et al. Diagnosis and detection of sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med 201: e26-e51, 2020.","DOI":"10.1164\/rccm.202002-0251ST"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Garcia-Pag\u00e1n JC, Valla DC. Primary Budd-Chiari syndrome. N Engl J Med 388: 1307-1316, 2023.","DOI":"10.1056\/NEJMra2207738"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ungprasert P, Crowson CS, Simonetto DA, Matteson EL. Clinical characteristics and outcome of hepatic sarcoidosis: a population-based study 1976-2013. Am J Gastroenterol 112: 1556-1563, 2017.","DOI":"10.1038\/ajg.2017.231"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Ren W, Qi X, Yang Z, Han G, Fan D. Prevalence and risk factors of hepatocellular carcinoma in Budd-Chiari syndrome: a systematic review. Eur J Gastroenterol Hepatol 25: 830-841, 2013.","DOI":"10.1097\/MEG.0b013e32835eb8d4"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Sedki M, Fonseca N, Santiago P, et al. Hepatic sarcoidosis: natural history and management implications. Front Med (Lausanne) 6: 232, 2019.","DOI":"10.3389\/fmed.2019.00232"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Nagai Y, Takagi K, Yasui K, Kariyama K, Fuji T, Fujiwara T. A case of hepatocellular carcinoma associated with hepatic sarcoidosis. JMA J 8: 606-608, 2025.","DOI":"10.31662\/jmaj.2024-0387"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Arai T, Akita S, Sakon M, et al. Hepatocellular carcinoma associated with sarcoidosis. Int J Surg Case Rep 5: 562-565, 2014.","DOI":"10.1016\/j.ijscr.2014.06.018"},{"key":"8","unstructured":"8. Ogata S, Horio T, Sugiura Y, et al. Sarcoidosis-associated hepatocellular carcinoma. Acta Med Okayama 64: 407-410, 2010."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Chalasani P, Vohra M, Sheagren JN. An association of sarcoidosis with hepatocellular carcinoma. Ann Oncol 16: 1714-1715, 2005.","DOI":"10.1093\/annonc\/mdi306"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Wong VS, Adab N, Youngs GR, Sturgess R. Hepatic sarcoidosis complicated by hepatocellular carcinoma. Eur J Gastroenterol Hepatol 11: 353-355, 1999.","DOI":"10.1097\/00042737-199903000-00023"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kronborg IJ, Bhathal PS, Mackay IR, Storey E, Long TM. Hepatocellular carcinoma in a patient with sarcoidosis-associated chronic active hepatitis and the MZ alpha-1-antitrypsin phenotype. Liver 3: 92-99, 1983.","DOI":"10.1111\/j.1600-0676.1983.tb00855.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Yasuda H, Sakurai M, Kitamura H, Fujita S. Hepatocellular carcinoma and myocardial sarcoidosis. - An autopsy case. Acta Pathol Jpn 28: 653-661, 1978.","DOI":"10.1111\/j.1440-1827.1978.tb00904.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Li KS, Guo S, Chen YX, Zhang ZL. Budd-Chiari syndrome and its associated hepatocellular carcinoma: clinical risk factors and potential immunotherapeutic benefit analysis. Front Oncol 12: 1075685, 2022.","DOI":"10.3389\/fonc.2022.1075685"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Moucari R, Rautou PE, Cazals-Hatem D, et al. Hepatocellular carcinoma in Budd-Chiari syndrome: characteristics and risk factors. Gut 57: 828-835, 2008.","DOI":"10.1136\/gut.2007.139477"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Arshad H, Crawford CK, Fishman EK. Hepatic sarcoidosis presenting as Budd Chiari syndrome leading to cirrhosis. Radiol Case Rep 20: 4138-4143, 2025.","DOI":"10.1016\/j.radcr.2025.05.019"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Odah T, Al-Khazraji A, Idriss R, Morrow M, Curry MP. Budd-Chiari syndrome in a patient with simultaneous diagnosis of hepatic sarcoidosis and nodular regenerative hyperplasia. ACG Case Rep J 6: e00200, 2019.","DOI":"10.14309\/crj.0000000000000200"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sghier IA, Billah NM. [Budd-Chiari syndrome: a rare complication of hepatic sarcoidosis (about one case)]. Pan Afr Med J 23: 4, 2016 (in French).","DOI":"10.11604\/pamj.2016.23.4.8564"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Ennaifer R, Bacha D, Romdhane H, Cheikh M, Nejma HB, BelHadj N. Budd-Chiari syndrome: an unusual presentation of multisystemic sarcoidosis. Clin Pract 5: 768, 2015.","DOI":"10.4081\/cp.2015.768"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Efe C, Shorbagi A, Ozseker B, et al. Budd-Chiari syndrome as a rare complication of sarcoidosis. Rheumatol Int 32: 3319-3320, 2012.","DOI":"10.1007\/s00296-011-2129-y"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Van Brusselen D, Janssen CE, Scott C, et al. Budd-Chiari syndrome as presenting symptom of hepatic sarcoidosis in a child, with recurrence after liver transplantation. Pediatr Transplant 16: E58-E62, 2012.","DOI":"10.1111\/j.1399-3046.2011.01535.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Delfosse V, de Leval L, De Roover A, et al. Budd-Chiari syndrome complicating hepatic sarcoidosis: definitive treatment by liver transplantation: a case report. Transplant Proc 41: 3432-3434, 2009.","DOI":"10.1016\/j.transproceed.2009.09.021"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Deniz K, Ward SC, Rosen A, Grewal P, Xu R. Budd-Chiari syndrome in sarcoidosis involving liver. Liver Int 28: 580-581, 2008.","DOI":"10.1111\/j.1478-3231.2007.01633.x"},{"key":"23","unstructured":"23. Russi EW, Bansky G, Pfaltz M, Spinas G, Hammer B, Senning A. Budd-Chiari syndrome in sarcoidosis. Am J Gastroenterol 81: 71-75, 1986."},{"key":"24","unstructured":"24. Weinberg EM, Aghayeva S, Reddy RK. Hepatic sarcoid - a review. Hepatology. Forthcoming."},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Nath B, Szabo G. Hypoxia and hypoxia inducible factors: diverse roles in liver diseases. Hepatology 55: 622-633, 2012.","DOI":"10.1002\/hep.25497"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Kierans SJ, Taylor CT. Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology. J Physiol 599: 23-37, 2021.","DOI":"10.1113\/JP280572"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Copple BL, Bai S, Burgoon LD, Moon JO. Hypoxia-inducible factor-1\u03b1 regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis. Liver Int 31: 230-244, 2011.","DOI":"10.1111\/j.1478-3231.2010.02347.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Wang Y, Huang Y, Guan F, et al. Hypoxia-inducible factor-1alpha and MAPK co-regulate activation of hepatic stellate cells upon hypoxia stimulation. PLoS One 8: e74051, 2013.","DOI":"10.1371\/journal.pone.0074051"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Drent M, Crouser ED, Grunewald J. Challenges of sarcoidosis and its management. N Engl J Med 385: 1018-1032, 2021.","DOI":"10.1056\/NEJMra2101555"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Malkov MI, Lee CT, Taylor CT. Regulation of the hypoxia-inducible factor (HIF) by pro-inflammatory cytokines. Cells 10: 2340, 2021.","DOI":"10.3390\/cells10092340"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Copple BL, Kaska S, Wentling C. Hypoxia-inducible factor activation in myeloid cells contributes to the development of liver fibrosis in cholestatic mice. J Pharmacol Exp Ther 341: 307-316, 2012.","DOI":"10.1124\/jpet.111.189340"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Shi YF, Fong CC, Zhang Q, et al. Hypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-beta signaling pathway. FEBS Lett 581: 203-210, 2007.","DOI":"10.1016\/j.febslet.2006.12.010"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Greuter T, Shah VH. Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights. J Gastroenterol 51: 511-519, 2016.","DOI":"10.1007\/s00535-016-1190-4"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Liu FY, Wang MQ, Duan F, Fan QS, Song P, Wang Y. Hepatocellular carcinoma associated with Budd-Chiari syndrome: imaging features and transcatheter arterial chemoembolization. BMC Gastroenterol 13: 105, 2013.","DOI":"10.1186\/1471-230X-13-105"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Aglago EK, Ramos I, Keski-Rahkonen P, et al. Alcohol and smoking habits in association with hepatocellular carcinoma risk. Int J Cancer 157: 644-657, 2025.","DOI":"10.1002\/ijc.35401"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Petrick JL, Campbell PT, Koshiol J, et al. Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: the Liver Cancer Pooling Project. Br J Cancer 118: 1005-1012, 2018.","DOI":"10.1038\/s41416-018-0007-z"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Rautou PE, Douarin L, Denninger MH, et al. Bleeding in patients with Budd-Chiari syndrome. J Hepatol 54: 56-63, 2011.","DOI":"10.1016\/j.jhep.2010.06.019"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Northup PG, Garcia-Pagan JC, Garcia-Tsao G, et al. Vascular liver disorders, portal vein thrombosis, and procedural bleeding in patients with liver disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology 73: 366-413, 2021.","DOI":"10.1002\/hep.31646"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Xia Y, Li J, Liu G, et al. Long-term effects of repeat hepatectomy vs percutaneous radiofrequency ablation among patients with recurrent hepatocellular carcinoma: a randomized clinical trial. JAMA Oncol 6: 255-263, 2020.","DOI":"10.1001\/jamaoncol.2019.4477"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Drent M, Crouser ED, Grunewald J. Challenges of sarcoidosis and its management. N Engl J Med 385: 1018-1032, 2021.","DOI":"10.1056\/NEJMra2101555"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/19\/65_6849-25\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:30:36Z","timestamp":1790998236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/65\/19\/65_6849-25\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":40,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.6849-25","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"6849-25"}}