{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:03:34Z","timestamp":1783191814704,"version":"3.54.6"},"reference-count":24,"publisher":"Japanese Society of Internal Medicine","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026]]},"DOI":"10.2169\/internalmedicine.7238-26","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:10:09Z","timestamp":1781734209000},"source":"Crossref","is-referenced-by-count":1,"title":["Severe Acute Meningoencephalitis Associated with <i>Mycoplasma pneumoniae<\/i> Infection in a Young Adult Successfully Treated with Immunotherapy"],"prefix":"10.2169","author":[{"given":"Kotaro","family":"Haruna","sequence":"first","affiliation":[{"name":"Department of Neurology, Kobe City Medical Center General Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kobe City Medical Center General Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michi","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kobe City Medical Center General Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Gavaud A, Holub M, Asquier-Khati A, et al. Mycoplasma pneumoniae infection in adult inpatients during the 2023-24 outbreak in France (MYCADO): a national, retrospective, observational study. Lancet Infect Dis 25: 801-812, 2025."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. D'Alonzo R, Mencaroni E, Di Genova L, Laino D, Principi N, Esposito S. Pathogenesis and treatment of neurologic diseases associated with Mycoplasma pneumoniae infection. Front Microbiol 9: 2751, 2018.","DOI":"10.3389\/fmicb.2018.02751"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Fan G, Guo Y, Tang F, Chen M, Liao S, Wang J. Determining the clinical characteristics, treatment strategies, and prognostic factors for Mycoplasma pneumoniae encephalitis in children: a multicenter study in China. J Clin Neurol 19: 402-409, 2023.","DOI":"10.3988\/jcn.2022.0328"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Daba M, Kang PB, Sladky J, Bidari SS, Lawrence RM, Ghosh S. Intravenous immunoglobulin as a therapeutic option for Mycoplasma pneumoniae encephalitis. J Child Neurol 34: 687-691, 2019.","DOI":"10.1177\/0883073819854854"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. \u00d6zel C, Dafotakis M, Nikoubashman O, Litmathe J, Matz O, Sch\u00f6ne U. Mykoplasma-pneumoniae-assoziierte Meningoenzephalitis. Fortschr Neurol Psychiatr 83: 392-396, 2015 (in German).","DOI":"10.1055\/s-0035-1553233"},{"key":"6","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1309\/0D1FGL7AJXE3VQBY","volume":"36","author":"Z Mandolin","year":"2005","unstructured":"6. Mandolin Z, Frank HW. A Guide to the Interpretation of CSF Indices. Laboratory Medicine 36: 558-562, 2005.","journal-title":"Laboratory Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0007-5027","issn-type":"print"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Christie LJ, Honarmand S, Talkington DF, et al. Pediatric encephalitis: what is the role of Mycoplasma pneumoniae? Pediatrics 120: 305-313, 2007.","DOI":"10.1542\/peds.2007-0240"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Horton M, Nguyen ML, Mateus Twitchell M. Atypical Cause of Autoimmune Encephalitis: The Role of Mycoplasma pneumoniae in Status Epilepticus. Cureus 17: e84689, 2025.","DOI":"10.7759\/cureus.84689"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Horvath T, Fischer U, M\u00fcller L, et al. Mycoplasma-induced minimally conscious state. Springerplus 5: 143, 2016.","DOI":"10.1186\/s40064-016-1832-2"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Decaux G, Szyper M, Ectors M, Cornil A, Franken L. Central nervous system complications of Mycoplasma pneumoniae. J Neurol Neurosurg Psychiatry 43: 883-887, 1980.","DOI":"10.1136\/jnnp.43.10.883"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Xia C, Chen HS. Anti-GM2 Antibodies in Mycoplasma Pneumoniae-Associated Acute Encephalomyelitis. Can J Neurol Sci 47: 258-260, 2020.","DOI":"10.1017\/cjn.2019.337"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Woo MH, Shin JW. Acute brainstem encephalitis associated with Mycoplasma pneumoniae in an adult: a case report. Encephalitis 1: 120-123, 2021.","DOI":"10.47936\/encephalitis.2021.00101"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Watanabe T, Hatta K, Ota T, Shimo Y, Arai H. Central nervous system disease complicating Mycoplasma pneumoniae. Psychiatry Clin Neurosci 61: 577, 2007.","DOI":"10.1111\/j.1440-1819.2007.01713.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Nishimura M, Saida T, Kuroki S, et al. Post-infectious encephalitis with anti-galactocerebroside antibody subsequent to Mycoplasma pneumoniae infection. J Neurol Sci 140: 91-95, 1996.","DOI":"10.1016\/0022-510X(96)00106-2"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Takata T, Hirakawa M, Sakurai M, Kanazawa I. Fulminant form of acute disseminated encephalomyelitis: successful treatment with hypothermia. J Neurol Sci 165: 94-97, 1999.","DOI":"10.1016\/S0022-510X(99)00089-1"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Perez C, Montes M. Cutaneous leukocytoclastic vasculitis and encephalitis associated with Mycoplasma pneumoniae infection. Arch Intern Med 162: 352-354, 2002.","DOI":"10.1001\/archinte.162.3.352"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Stettner M, Albrecht P, Derksen A, et al. Clinical improvement precedes lesion size regression in a severe case of acute disseminated encephalomyelitis. BMJ Case Rep 2012: bcr-2012-006844, 2012.","DOI":"10.1136\/bcr-2012-006844"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Fisher RS, Clark AW, Wolinsky JS, Parhad IM, Moses H, Mardiney MR. Postinfectious leukoencephalitis complicating Mycoplasma pneumoniae infection. Arch Neurol 40: 109-113, 1983.","DOI":"10.1001\/archneur.1983.04050020071016"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Hagiwara H, Sakamoto S, Katsumata T, Katayama Y. Acute disseminated encephalomyelitis developed after Mycoplasma pneumoniae infection complicating subclinical measles infection. Intern Med 48: 479-483, 2009.","DOI":"10.2169\/internalmedicine.48.1740"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Stamm B, Moschopulos M, Hungerbuehler H, Guarner J, Genrich GL, Zaki SR. Neuroinvasion by Mycoplasma pneumoniae in acute disseminated encephalomyelitis. Emerg Infect Dis 14: 641-643, 2008.","DOI":"10.3201\/eid1404.061366"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Feil K, Ruf B, Behling F, et al. Case Report: severe Mycoplasma pneumoniae-associated acute disseminated encephalomyelitis in an adult: challenges in diagnosis and management. Front Med (Lausanne) 12: 1627241, 2025.","DOI":"10.3389\/fmed.2025.1627241"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Narita M, Itakura O, Matsuzono Y, Togashi T. Analysis of mycoplasmal central nervous system involvement by polymerase chain reaction. Pediatr Infect Dis J 14: 236-237, 1995.","DOI":"10.1097\/00006454-199503000-00013"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Bitnun A, Ford-Jones EL, Petric M, et al. Acute childhood encephalitis and Mycoplasma pneumoniae. Clin Infect Dis 32: 1674-1684, 2001.","DOI":"10.1086\/320748"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Felgenhauer K, Schliep G, Rapic N. Evaluation of the blood-CSF barrier by protein gradients and the humoral immune response within the central nervous system. J Neurol Sci 30: 113-128, 1976.","DOI":"10.1016\/0022-510X(76)90259-8"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_7238-26\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:37:50Z","timestamp":1781926670000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_7238-26\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":24,"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.7238-26","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"7238-26"}}