{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:06:14Z","timestamp":1779509174204,"version":"3.53.1"},"reference-count":44,"publisher":"Japanese Society of Internal Medicine","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026]]},"DOI":"10.2169\/internalmedicine.7350-26","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T22:09:31Z","timestamp":1779487771000},"source":"Crossref","is-referenced-by-count":0,"title":["Determinants of the Mid-term Improvement or Deterioration of the Ejection Fraction in Patients with an ST-segment Elevation Myocardial Infarction"],"prefix":"10.2169","author":[{"given":"Kiriha","family":"Nanri","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Sakakura","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Jinnouchi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousuke","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takunori","family":"Tsukui","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Hatori","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Seguchi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Fujita","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1. Bergmark BA, Mathenge N, Merlini PA, Lawrence-Wright MB, Giugliano RP. Acute coronary syndromes. Lancet 399: 1347-1358, 2022.","DOI":"10.1016\/S0140-6736(21)02391-6"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kraler S, Mueller C, Libby P, Bhatt DL. Acute coronary syndromes: mechanisms, challenges, and new opportunities. Eur Heart J 46: 2866-2889, 2025.","DOI":"10.1093\/eurheartj\/ehaf289"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kurita T, Hirota Y, Mori H, et al. Prehospital Vital Signs, Including SpO2, Are Significantly Associated With Mortality and Mechanical Circulatory Support Requirement in Acute Myocardial Infarction Patients. Circ J 89: 1833-1835, 2025.","DOI":"10.1253\/circj.CJ-25-0584"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Kanaji Y, Yamaji K, Kunimura A, et al. Prognostic Impact of COVID-19 on Patients With Acute Coronary Syndrome Undergoing Emergent Percutaneous Coronary Intervention - Insights From the J-PCI Nationwide Registry. Circ J 2026.","DOI":"10.1253\/circj.CJ-25-0705"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Bhatt DL, Lopes RD, Harrington RA. Diagnosis and Treatment of Acute Coronary Syndromes: A Review. Jama 327: 662-675, 2022.","DOI":"10.1001\/jama.2022.0358"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6. Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. Lancet 389: 197-210, 2017.","DOI":"10.1016\/S0140-6736(16)30677-8"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Gaudino M, Andreotti F, Kimura T. Current concepts in coronary artery revascularisation. Lancet 401: 1611-1628, 2023.","DOI":"10.1016\/S0140-6736(23)00459-2"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Zuccarelli V, Andreaggi S, Walsh JL, et al. Treatment and Care of Patients with ST-Segment Elevation Myocardial Infarction-What Challenges Remain after Three Decades of Primary Percutaneous Coronary Intervention?. J Clin Med 13: 2923, 2024.","DOI":"10.3390\/jcm13102923"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Thrane PG, Olesen KKW, Thim T, et al. Mortality Trends After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol 82: 999-1010, 2023.","DOI":"10.1016\/j.jacc.2023.06.025"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Ndrepepa G, Cassese S, Byrne RA, et al. Left Ventricular Ejection Fraction Change Following Percutaneous Coronary Intervention: Correlates and Association With Prognosis. J Am Heart Assoc 13: e035791, 2024.","DOI":"10.1161\/JAHA.124.035791"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Udell JA, Bahit MC, Campbell P, et al. Prevention of heart failure after acute myocardial infarction. Lancet 406: 1154-1170, 2025.","DOI":"10.1016\/S0140-6736(25)01394-7"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Stolfo D, Cinquetti M, Merlo M, et al. ST-elevation myocardial infarction with reduced left ventricular ejection fraction: Insights into persisting left ventricular dysfunction. A pPCI-registry analysis. Int J Cardiol 215: 340-345, 2016.","DOI":"10.1016\/j.ijcard.2016.04.097"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Dauw J, Martens P, Deferm S, et al. Left ventricular function recovery after ST-elevation myocardial infarction: correlates and outcomes. Clin Res Cardiol 110: 1504-1515, 2021.","DOI":"10.1007\/s00392-021-01887-y"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Lenselink C, Ricken K, Groot HE, et al. Incidence and predictors of heart failure with reduced and preserved ejection fraction after ST-elevation myocardial infarction in the contemporary era of early percutaneous coronary intervention. Eur J Heart Fail 26: 1142-1149, 2024.","DOI":"10.1002\/ejhf.3225"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Serrao GW, Lansky AJ, Mehran R, Stone GW. Predictors of Left Ventricular Ejection Fraction Improvement After Primary Stenting in ST-Segment Elevation Myocardial Infarction (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Trial). Am J Cardiol 121: 678-683, 2018.","DOI":"10.1016\/j.amjcard.2017.12.004"},{"key":"16","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","volume":"138","author":"K Thygesen","year":"2018","unstructured":"16. Thygesen K, Alpert JS, Jaffe AS, et al. Fourth Universal Definition of Myocardial Infarction (2018). Circulation 138: e618-e651, 2018.","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kobayashi S, Sakakura K, Jinnouchi H, et al. Influence of daily temperature on the occurrence of ST-elevation myocardial infarction. J Cardiol 81: 544-552, 2023.","DOI":"10.1016\/j.jjcc.2022.12.005"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Tokunaga Y, Sakakura K, Jinnouchi H, et al. Determinants of In-hospital Death in Non-ST-segment Elevation Myocardial Infarction with Triple-vessel Disease. Intern Med 64: 993-999, 2025.","DOI":"10.2169\/internalmedicine.3949-24"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Yanase T, Sakakura K, Taniguchi Y, et al. Comparison of Clinical Characteristics of Acute Myocardial Infarction Between Young (&lt;55 Years) and Older (55 to &lt;70 Years) Patients. Int Heart J 62: 33-41, 2021.","DOI":"10.1536\/ihj.20-444"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Noguchi M, Sakakura K, Akashi N, et al. The Comparison of Clinical Outcomes Between Inferior ST-Elevation Myocardial Infarction with Right Ventricular Infarction Versus Without Right Ventricular Infarction. Int Heart J 60: 560-568, 2019.","DOI":"10.1536\/ihj.18-515"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ishibashi S, Sakakura K, Asada S, et al. Factors associated with difficulty in crossing the culprit lesion of acute myocardial infarction. Sci Rep 11: 21403, 2021.","DOI":"10.1038\/s41598-021-00832-3"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Aono-Setoguchi H, Sakakura K, Jinnouchi H, et al. Factors associated with intensive care unit delirium in patients with acute myocardial infarction. Heart Vessels 38: 478-487, 2023.","DOI":"10.1007\/s00380-022-02200-1"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Ban S, Sakakura K, Jinnouchi H, et al. Association of Increased Inter-arm Blood Pressure Difference with Long-term Clinical Outcomes in Patients with Acute Myocardial Infarction Who Underwent Percutaneous Coronary Intervention. Intern Med 63: 1043-1051, 2024.","DOI":"10.2169\/internalmedicine.2320-23"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ohashi J, Sakakura K, Jinnouchi H, et al. Comparison of Long-Term Clinical Outcomes in Patients Stratified by a Novel Acute Myocardial Infarction Risk Stratification (nARS) System. Circ J 86: 1519-1526, 2022.","DOI":"10.1253\/circj.CJ-22-0188"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Fujimoto Y, Sakakura K, Jinnouchi H, et al. Comparison of Outcomes of Patients With Acute Myocardial Infarction Between Chronic Total Occlusion Versus 90-99% Stenosis in Non-Culprit Arteries. Am J Cardiol 170: 17-24, 2022.","DOI":"10.1016\/j.amjcard.2022.01.021"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Akinwande MO, Dikko HG, Samson A. Variance Inflation Factor: As a Condition for the Inclusion of Suppressor Variable (s) in Regression Analysis. Open Journal of Statistics 05: 754-767, 2015.","DOI":"10.4236\/ojs.2015.57075"},{"key":"27","doi-asserted-by":"crossref","first-page":"e15725","DOI":"10.1111\/echo.15725","volume":"41","author":"A Yehia","year":"2024","unstructured":"27. Yehia A, Zaki A, Sadaka M, Azeem A. Incremental prognostic value of speckle tracking echocardiography and early follow-up echo assessment in predicting left ventricular recovery after reperfusion for ST-segment elevation myocardial infarction (STEMI). Echocardiography 41: e15725, 2024.","journal-title":"Echocardiography","ISSN":"https:\/\/id.crossref.org\/issn\/0742-2822","issn-type":"print"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Marcos-Garces V, Gavara J, Lopez-Lereu MP, et al. Ejection Fraction by Echocardiography for a Selective Use of Magnetic Resonance After Infarction. Circ Cardiovasc Imaging 13: e011491, 2020.","DOI":"10.1161\/CIRCIMAGING.120.011491"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Hasin T, Sorkin A, Markiewicz W, Hammerman H, Aronson D. Prevalence and prognostic significance of transient, persistent, and new-onset anemia after acute myocardial infarction. Am J Cardiol 104: 486-491, 2009.","DOI":"10.1016\/j.amjcard.2009.03.066"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Lee WC, Fang HY, Chen HC, et al. Anemia: A significant cardiovascular mortality risk after ST-segment elevation myocardial infarction complicated by the comorbidities of hypertension and kidney disease. PLoS One 12: e0180165, 2017.","DOI":"10.1371\/journal.pone.0180165"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Hartman MHT, Eppinga RN, Vlaar PJJ, et al. The contemporary value of peak creatine kinase-MB after ST-segment elevation myocardial infarction above other clinical and angiographic characteristics in predicting infarct size, left ventricular ejection fraction, and mortality. Clin Cardiol 40: 322-328, 2017.","DOI":"10.1002\/clc.22663"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Nienhuis MB, Ottervanger JP, de Boer MJ, et al. Prognostic importance of creatine kinase and creatine kinase-MB after primary percutaneous coronary intervention for ST-elevation myocardial infarction. Am Heart J 155: 673-679, 2008.","DOI":"10.1016\/j.ahj.2007.11.004"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Ndrepepa G, Mehilli J, Martinoff S, Schwaiger M, Sch\u00f6mig A, Kastrati A. Evolution of left ventricular ejection fraction and its relationship to infarct size after acute myocardial infarction. J Am Coll Cardiol 50: 149-156, 2007.","DOI":"10.1016\/j.jacc.2007.03.034"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Krefting J, Graesser C, Novacek S, et al. Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data. Clin Res Cardiol 114: 1692-1704, 2025.","DOI":"10.1007\/s00392-025-02627-2"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Guo RW, Yang LX, Liu B, et al. Effect of sex on recovery of ejection fraction in patients with anterior ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Coron Artery Dis 25: 133-137, 2014.","DOI":"10.1097\/MCA.0000000000000060"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Canali E, Masci P, Bogaert J, et al. Impact of gender differences on myocardial salvage and post-ischaemic left ventricular remodelling after primary coronary angioplasty: new insights from cardiovascular magnetic resonance. Eur Heart J Cardiovasc Imaging 13: 948-953, 2012.","DOI":"10.1093\/ehjci\/jes087"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Iwakura A, Shastry S, Luedemann C, et al. Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation 113: 1605-1614, 2006.","DOI":"10.1161\/CIRCULATIONAHA.105.553925"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Chen J, Liu Y, Pan D, et al. Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia\/reperfusion injury in rats by upregulating SERCA2a. Cell Commun Signal 20: 38, 2022.","DOI":"10.1186\/s12964-022-00842-2"},{"key":"39","doi-asserted-by":"publisher","unstructured":"39. Shehata IE, Cheng CI, Sung PH, Ammar AS, El-Sherbiny IAE, Ghanem IGA. Predictors of myocardial functional recovery following successful reperfusion of acute ST elevation myocardial infarction. Echocardiography 35: 1571-1578, 2018.","DOI":"10.1111\/echo.14106"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Elsman P, van &apos;t Hof AW, de Boer MJ, et al. Impact of infarct location on left ventricular ejection fraction after correction for enzymatic infarct size in acute myocardial infarction treated with primary coronary intervention. Am Heart J 151: 1239.e1239-1214, 2006.","DOI":"10.1016\/j.ahj.2005.12.006"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Bax M, de Winter RJ, Schotborgh CE, et al. Short- and long-term recovery of left ventricular function predicted at the time of primary percutaneous coronary intervention in anterior myocardial infarction. J Am Coll Cardiol 43: 534-541, 2004.","DOI":"10.1016\/j.jacc.2003.08.055"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Arcari L, Cimino S, De Luca L, et al. Impact of Heart Rate on Myocardial Salvage in Timely Reperfused Patients with ST-Segment Elevation Myocardial Infarction: New Insights from Cardiovascular Magnetic Resonance. PLoS One 10: e0145495, 2015.","DOI":"10.1371\/journal.pone.0145495"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Bellenger NG, Burgess MI, Ray SG, et al. Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable? Eur Heart J 21: 1387-1396, 2000.","DOI":"10.1053\/euhj.2000.2011"},{"key":"44","doi-asserted-by":"publisher","unstructured":"44. Wood PW, Choy JB, Nanda NC, Becher H. Left ventricular ejection fraction and volumes: it depends on the imaging method. Echocardiography 31: 87-100, 2014.","DOI":"10.1111\/echo.12331"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_7350-26\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T03:40:43Z","timestamp":1779507643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_7350-26\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":44,"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.7350-26","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"7350-26"}}