{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:06:06Z","timestamp":1794258366204,"version":"4.9.0"},"reference-count":37,"publisher":"Japanese Society of Internal Medicine","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026]]},"DOI":"10.2169\/internalmedicine.7718-26","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T22:10:58Z","timestamp":1787091058000},"source":"Crossref","is-referenced-by-count":1,"title":["Anti-Glomerular Basement Membrane Antibody Disease Complicated by Complement-Mediated Thrombotic Microangiopathy: A Case Report"],"prefix":"10.2169","author":[{"given":"Ryo","family":"Okino","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kanazawa University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitada","family":"Toyota","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kanazawa University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kanazawa University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kanazawa University Hospital, Japan"},{"name":"Department of General Medicine, Kanazawa University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kanazawa University Hospital, Japan"},{"name":"Department of General Medicine, Kanazawa University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kanazawa University Hospital, Japan"},{"name":"Division of Blood Purification Therapy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kanazawa University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. McAdoo SP, Pusey CD. Anti-glomerular basement membrane disease. Clin J Am Soc Nephrol 12: 1162-1172, 2017.","DOI":"10.2215\/CJN.01380217"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. George JN, Nester CM. Syndromes of thrombotic microangiopathy. N Engl J Med 371: 654-666, 2014.","DOI":"10.1056\/NEJMra1312353"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Palma LMP, Sridharan M, Sethi S. Complement in secondary thrombotic microangiopathy. Kidney Int Rep 6: 11-23, 2021.","DOI":"10.1016\/j.ekir.2020.10.009"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Honda N, Shigehara R, Furuhashi K, Nagai Y, Yokogawa N. Anti-glomerular basement membrane diseases and thrombotic microangiopathy treated with rituximab. Mod Rheumatol Case Rep 7: 422-425, 2023.","DOI":"10.1093\/mrcr\/rxac091"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Obeagu EI. Pathogenic cytokines in thrombotic microangiopathies: molecular insights and therapeutic targets. Mol Med 31: 316, 2025.","DOI":"10.1186\/s10020-025-01331-1"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Legendre CM, Licht C, Muus P, et al. Terminal complement inhibitor eculizumab in atypical hemolytic uremic syndrome. N Engl J Med 368: 2169-2181, 2013.","DOI":"10.1056\/NEJMoa1208981"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Li FK, Tse KC, Lam MF, et al. Incidence and outcome of antiglomerular basement membrane disease in Chinese. Nephrology (Carlton) 9: 100-104, 2004.","DOI":"10.1111\/j.1440-1797.2003.00234.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Stallworthy E, Yehia M. Thrombotic microangiopathy in a patient with anti-glomerular basement membrane antibody disease. Nephrology (Carlton) 11: 375-376, 2006.","DOI":"10.1111\/j.1440-1797.2006.00584.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Terryn W, Benoit D, Van Loo A, et al. Goodpasture&apos;s syndrome associated with autoimmune thrombotic thrombocytopenic purpura\u2014an unusual case. Nephrol Dial Transplant 22: 3672-3673, 2007.","DOI":"10.1093\/ndt\/gfm483"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kobayashi S, Inokuma S. Intrapulmonary hemorrhage in collagen vascular diseases includes a spectrum of underlying conditions. Intern Med 48: 891-897, 2009.","DOI":"10.2169\/internalmedicine.48.1760"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Gowrishankar S, Patro A, Maitra S. Anti-GBM antibody disease sans crescents with thrombotic microangiopathy. NDT Plus 2: 282-284, 2009.","DOI":"10.1093\/ndtplus\/sfp056"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Watanabe H, Kitagawa W, Suzuki K, et al. Thrombotic thrombocytopenic purpura in a patient with rapidly progressive glomerulonephritis with both anti-glomerular basement membrane antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies. Clin Exp Nephrol 14: 598-601, 2010.","DOI":"10.1007\/s10157-010-0312-1"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Torok N, Niazi M, Al Ahwel Y, Taleb M, Taji J, Assaly R. Thrombotic thrombocytopenic purpura associated with anti-glomerular basement membrane disease. Nephrol Dial Transplant 25: 3446-3449, 2010.","DOI":"10.1093\/ndt\/gfq437"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Miki T, Akimoto T, Sugase T, et al. Anti-glomerular basement membrane glomerulonephritis complicated by thrombocytopenia. Intern Med 51: 3395-3399, 2012.","DOI":"10.2169\/internalmedicine.51.8507"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Vega-Cabrera C, Del Peso G, Bajo A, et al. Goodpasture&apos;s syndrome associated with thrombotic thrombocytopenic purpura secondary to an ADAMTS13 deficit. Int Urol Nephrol 45: 1785-1789, 2013.","DOI":"10.1007\/s11255-012-0279-9"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Momose A, Nakajima T, Chiba S, et al. A case of fibrillary glomerulonephritis associated with thrombotic microangiopathy and anti-glomerular basement membrane antibody. Nephron Extra 5: 30-38, 2015.","DOI":"10.1159\/000371802"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Manabe S, Banno M, Nakano M, et al. A case of PR3-ANCA-positive anti-GBM disease associated with intrarenal arteritis and thrombotic microangiopathy. CEN Case Rep 6: 39-45, 2017.","DOI":"10.1007\/s13730-016-0240-3"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Yu X, Han S, Wang S, et al. Anti-glomerular basement membrane glomerulonephritis with thrombotic microangiopathy: a case report. Immunol Res 65: 769-773, 2017.","DOI":"10.1007\/s12026-017-8918-y"},{"key":"19","unstructured":"19. Alirezaei A, Bakhtiyari M, Zare E. Anti-GBM disease with TTP. Case Rep Clin Pract 3: 106-112, 2019."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Malviya PB, Modigonda S, Maitra S, et al. Anti-GBM disease with atypical associations. Saudi J Kidney Dis Transpl 32: 227-231, 2021.","DOI":"10.4103\/1319-2442.318529"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Torigoe M, Obata Y, Kitamura M, et al. Anti-glomerular basement membrane disease with antiphospholipid syndrome. Intern Med 60: 2255-2260, 2021.","DOI":"10.2169\/internalmedicine.4943-20"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Nakamura Y, Kato N, Tatematsu Y, et al. Clinical characteristics of anti-GBM disease with thrombotic microangiopathy: a case report and literature review. CEN Case Rep 13: 37-44, 2024.","DOI":"10.1007\/s13730-023-00797-4"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Persson BD, Schmitz NB, Santiago C, et al. Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens. PLoS Pathog 6: e1001122, 2010.","DOI":"10.1371\/journal.ppat.1001122"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Feng S, Gale DP, Mao J, et al. Comprehensive analysis of complement genes in patients with atypical hemolytic uremic syndrome. Am J Nephrol 43: 160-169, 2016.","DOI":"10.1159\/000445127"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Kavanagh D, Goodship TH, Richards A. Atypical hemolytic uremic syndrome. Semin Nephrol 33: 508-530, 2013.","DOI":"10.1016\/j.semnephrol.2013.08.003"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Java A. Atypical hemolytic uremic syndrome: diagnosis, management, and discontinuation of therapy. Hematology Am Soc Hematol Educ Program 2024: 200-205, 2024.","DOI":"10.1182\/hematology.2024000543"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Tang A, Zhao X, Tao T, et al. Unraveling renal damage in human anti-glomerular basement membrane disease. Front Immunol 14: 1229806, 2023.","DOI":"10.3389\/fimmu.2023.1229806"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Hu S, Jia X, Yang X, Yu F, Cui Z, Zhao M. Glomerular C1q deposition and serum anti-C1q antibodies in anti-glomerular basement membrane disease. BMC Immunol 14: 42, 2013.","DOI":"10.1186\/1471-2172-14-42"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Ma R, Cui Z, Liao Y, Zhao M. Complement activation contributes to kidney injury and outcome in anti-glomerular basement membrane disease. J Clin Immunol 33: 172-178, 2013.","DOI":"10.1007\/s10875-012-9772-2"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Otten MA, Groeneveld TWL, Flierman R, et al. Both complement and IgG Fc receptors are required for development of anti-glomerular basement membrane nephritis in mice. J Immunol 183: 3980-3988, 2009.","DOI":"10.4049\/jimmunol.0901301"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Kondo C, Mizuno M, Nishikawa K, Yuzawa Y, Hotta N, Matsuo S. The role of C5a in the development of thrombotic glomerulonephritis in rats. Clin Exp Immunol 124: 323-329, 2001.","DOI":"10.1046\/j.1365-2249.2001.01513.x"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Harkins VJ, McAllister DA, Reynolds BC. Shiga toxin-producing Escherichia coli hemolytic uremic syndrome: review of management and long-term outcome. Curr Pediatr Rep 8: 16-25, 2020.","DOI":"10.1007\/s40124-020-00208-7"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. George JN. How I treat patients with thrombotic thrombocytopenic purpura. Blood 116: 4060-4069, 2010.","DOI":"10.1182\/blood-2010-07-271445"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Cochran JB, Panzarino VM, Maes LY, Tecklenburg FW. Pneumococcus-induced T-antigen activation in hemolytic uremic syndrome and anemia. Pediatr Nephrol 19: 317-321, 2004.","DOI":"10.1007\/s00467-003-1382-z"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Noris M, Caprioli J, Bresin E, et al. Relative role of genetic complement abnormalities in sporadic and familial atypical hemolytic uremic syndrome and their impact on clinical phenotype. Clin J Am Soc Nephrol 5: 1844-1859, 2010.","DOI":"10.2215\/CJN.02210310"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Hirano R, Namazuda K, Suemitsu J, Harashima T, Hirata N. Plasma separation using a membrane. Transfus Apher Sci 56: 649-653, 2017.","DOI":"10.1016\/j.transci.2017.08.008"},{"key":"37","unstructured":"37. Hirose S, Ichikawa K, Kondoh T, et al. Clinical use of a newly developed membrane plasma separator made of polyethylene hollow fiber. Jpn J Artif Organs 17: 332-335, 1988."}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_7718-26\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T04:10:51Z","timestamp":1787371851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_7718-26\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":37,"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.7718-26","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"7718-26"}}