{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:04:01Z","timestamp":1789790641789,"version":"4.0.1"},"reference-count":13,"publisher":"Japanese Society of Internal Medicine","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2026]]},"DOI":"10.2169\/internalmedicine.7852-26","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:11:38Z","timestamp":1789423898000},"source":"Crossref","is-referenced-by-count":0,"title":["Acquired Pure Red Cell Aplasia Secondary to Indolent Mature T-cell Lymphoid Malignancy"],"prefix":"10.2169","author":[{"given":"Saya","family":"Motohashi","sequence":"first","affiliation":[{"name":"Hematology Division, National Hospital Organization Disaster Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Hematology Division, National Hospital Organization Disaster Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Hirano","sequence":"additional","affiliation":[{"name":"Laboratory and Pathology Division, National Hospital Organization Disaster Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Hematology Division, National Hospital Organization Disaster Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Means RT Jr. Pure red cell aplasia. Blood 128: 2504-2509, 2016.","DOI":"10.1182\/blood-2016-05-717140"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kawakami F, Kawakami T, et al. T cell clonal expansion and STAT3 mutations: a characteristic feature of acquired chronic T cell-mediated pure red cell aplasia. Int J Hematol 115: 816-825, 2022.","DOI":"10.1007\/s12185-022-03310-2"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kawahigashi T, Kitagawa I, et al. Angioimmunoblastic T-cell lymphoma accompanied by pure red cell aplasia: a case report. World J Clin Oncol 11: 405-411, 2020.","DOI":"10.5306\/wjco.v11.i6.405"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Kubota Y, Sano H, et al. Pure red cell aplasia in a patient with thymic hyperplasia, hypogammaglobulinemia and adult T-cell leukemia\/lymphoma. Intern Med 64: 1393-1398, 2025.","DOI":"10.2169\/internalmedicine.4443-24"},{"key":"5","unstructured":"5. Morice WG, Cheng CL, et al. T-large granular lymphocytic leukemia. In: The WHO Classification of Tumours Editorial Board, Eds. World Health Organization classification of tumours. 5th ed. Haematolymphoid tumours. IARC Press: Lyon, France, 2024; 662-664."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Park SH, Lee YJ, et al. T-large granular lymphocytic leukemia. Blood Res 58: S52-S57, 2023.","DOI":"10.5045\/br.2023.2023037"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Iijima M, Sekiguchi N, et al. Gamma heavy chain disease with T-cell large granular lymphocytic leukemia: a case report and review of the literature. Intern Med 55: 399-403, 2016.","DOI":"10.2169\/internalmedicine.55.5042"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Lamy T, Moignet A, et al. LGL leukemia: from pathogenesis to treatment. Blood 129: 1082-1094, 2017.","DOI":"10.1182\/blood-2016-08-692590"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Mohan SR, Clemente MJ, et al. Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia. Haematologica 94: 1407-1414, 2009.","DOI":"10.3324\/haematol.2009.009191"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Shen M. A case report of T-LGL leukemia-associated pure red cell aplasia harboring STAT3, TNFAIP3, and KMT2D mutation. Transl Cancer Res 12: 1054-1059, 2023.","DOI":"10.21037\/tcr-23-326"},{"key":"11","unstructured":"11. Felgar RE, Macon WR, et al. TIA-1 expression in lymphoid neoplasms. Identification of subsets with cytotoxic T lymphocyte or natural killer cell differentiation. Am J Pathol 150: 1893-1900, 1997."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Morice WG, Kurtin PJ, et al. Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B. Blood 99: 268-274, 2002.","DOI":"10.1182\/blood.V99.1.268"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Qiu ZY, Qin R, Tian GY, et al. Pathophysiologic mechanisms and management of large granular lymphocytic leukemia associated pure red cell aplasia. Onco Targets Ther 12: 8229-8240, 2019.","DOI":"10.2147\/OTT.S222378"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_7852-26\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:30:41Z","timestamp":1789788641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/advpub\/0\/advpub_7852-26\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":13,"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.7852-26","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"7852-26"}}