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Nervenarzt 60: 545-548, 1989."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Dengler R, Wohlfarth K, Zierz S, Jobges M, Schubert M. Muscle fatigue, lactate, and pyruvate in mitochondrial myopathy with progressive external ophthalmoplegia. Muscle Nerve 19: 456-462, 1996.","DOI":"10.1002\/(SICI)1097-4598(199604)19:4<456::AID-MUS5>3.0.CO;2-B"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Chan A, Gold R, Arp S, Pflughaupt KW, Toyka KV, Reichmann H. A standardised bicycle ergometer test in the diagnosis and monitoring of mitochondrial myopathies. Nervenarzt 69: 472-484, 1998.","DOI":"10.1007\/s001150050300"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Chan A, Reichmann H, K\u00f6gel A, Beck A, Gold R. Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q10 therapy. J Neurol 245: 681-685, 1998.","DOI":"10.1007\/s004150050267"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Schmidt M, Kunkel M, Schuff-Werner P, Naumann M, Reichmann H, Reimers CD. Standardisierte aerobe Gehbelastung auf dem Laufband bei Gesunden sowie Patienten mit mitochondrialen und nichtmitochondrialen Myopathien. Nervenarzt 68: 831-835, 1997.","DOI":"10.1007\/s001150050201"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Finsterer J, Shorny S, Capek J, et al. Lactate stress test in the diagnosis of mitochondrial myopathy. J Neurol Sci 159: 176-180, 1998.","DOI":"10.1016\/S0022-510X(98)00170-1"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Finsterer J, Eichberger H, Jarius C. Lactate-stress testing in 54 patients with mitochondriopathy. Eur Arch Psychiatry Clin Neurosci 250: 36-39, 2000.","DOI":"10.1007\/PL00007537"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Finsterer J, Obermann I, Milvay E. Diagnostic yield of the lactate stress test in 160 patients with suspected respiratory chain disorder. 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Investigation of the freely available easy-to-use software &apos;EZR&apos; for medical statistics. Bone Marrow Transplant 48: 452-458, 2013.","DOI":"10.1038\/bmt.2012.244"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Mitsutake A, Matsukawa T, Ishiura H, et al. A case of late-onset Krabbe disease which showed subacute progression of spastic paresis with bilateral spinal cord lesions. Neurol Clin Neurosci 6: 104-106, 2018.","DOI":"10.1111\/ncn3.12188"},{"key":"30","unstructured":"30. Siciliano G, Pasquali L, Manca ML, et al. The relationship between anaerobic lactate threshold and plasma catecholamines during incremental exercise in hereditary spastic paraplegia. Funct Neurol 18: 83-87, 2003."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Ciammola A, Sassone J, Sciacco M, et al. Low anaerobic threshold and increased skeletal muscle lactate production in subjects with Huntington&apos;s disease. Mov Disord 26: 130-137, 2011.","DOI":"10.1002\/mds.23258"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Finsterer J. Lactate stress testing in sporadic amyotrophic lateral sclerosis. Int J Neurosci 115: 583-591, 2005.","DOI":"10.1080\/00207450590522847"},{"key":"#cr-split#-33.1","unstructured":"33. DiMauro S, Hirano M. MERRF. In: GeneReviews. Adam MP, Ardinger HH, Pagon RA, et al., Eds. University of Washington, Seattle. [Internet]. June 3, 2003 [updated 2015 Jan 29"},{"key":"#cr-split#-33.2","unstructured":"cited 2021 May 1]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1520\/"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Sakushima K, Tsuji-Akimoto S, Niino M, Saitoh S, Yabe I, Sasaki H. Adult Leigh disease without failure to thrive. Neurologist 17: 222-227, 2011.","DOI":"10.1097\/NRL.0b013e318217357a"},{"key":"35","unstructured":"35. Mitani M, Jinnai K, Takahashi K, Koide R, Tsuji S. 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