{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:55:17Z","timestamp":1782845717114,"version":"3.54.5"},"reference-count":21,"publisher":"Japanese Society of Internal Medicine","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2022,9,15]]},"DOI":"10.2169\/internalmedicine.8710-21","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T22:10:05Z","timestamp":1645827005000},"page":"2753-2757","source":"Crossref","is-referenced-by-count":6,"title":["Graves' Disease with Thymic Hyperplasia: The Response of the Thyroid Function, Thyrotropin Receptor Autoantibody, and Thymic Size to Thiamazole Treatment"],"prefix":"10.2169","volume":"61","author":[{"given":"Daichi","family":"Tsukada","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"},{"name":"Department of Clinical Nutrition, Fujita Health University, Japan"},{"name":"Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institution, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Takao","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sodai","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"},{"name":"Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institution, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Okamoto-Kubota","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"},{"name":"Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institution, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruaki","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Suwa","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Horikawa","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Health Administration Center, Gifu University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumihisa","family":"Kubota","sequence":"additional","affiliation":[{"name":"Kubota Thyroid Clinic, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Yabe","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism\/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Japan"},{"name":"Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institution, Japan"},{"name":"Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Japan"},{"name":"Center for Healthcare Information Technology, Tokai National Higher Education and Research System, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Gunn A, Michie W, Irvine WJ. The thymus in thyroid disease. Lancet 10: 76-78, 1964."},{"key":"2","doi-asserted-by":"publisher","unstructured":"2. Popoveniuc G, Sharma M, Devdhar M, et al. Graves&apos; disease and thymic hyperplasia: the relationship of thymic volume to thyroid function. Thyroid 20: 1015-1018, 2010.","DOI":"10.1089\/thy.2009.0383"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Haider U, Richards P, Gianoukakis AG. Thymic hyperplasia associated with Graves&apos; disease: pathophysiology and proposed management algorithm. Thyroid 27: 994-1000, 2017.","DOI":"10.1089\/thy.2017.0086"},{"key":"4","unstructured":"4. Inoue K, Sugio K, Inoue T, et al. Hyperplasia of the thymic gland in a patient with Graves&apos; disease. Ann Thorac Cardiovasc Surg 6: 397-400, 2000."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Voss M, Saeed ZI, Donegan D. Not a grave finding: thymic hyperplasia in the setting of Graves&apos; disease. Am J Med 133: 308-310, 2020.","DOI":"10.1016\/j.amjmed.2019.07.051"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Wan W, Colburn JA. Massive thymic hyperplasia secondary to Graves&apos; disease. AACE Clin Case Rep 6: e144-e146, 2020.","DOI":"10.4158\/ACCR-2019-0423"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Damoiseaux J. The IL-2 - IL-2 receptor pathway in health and disease: the role of the soluble IL-2 receptor. Clin Immunol 218: 108515, 2020.","DOI":"10.1016\/j.clim.2020.108515"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Smallridge RC, Tsokos GC, Burman KD, et al. Soluble interleukin-2 receptor is a thyroid hormone-dependent early-response marker in the treatment of thyrotoxicosis. Clin Diagn Lab Immunol 4: 583-586, 1997.","DOI":"10.1128\/cdli.4.5.583-586.1997"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Ricci C, Pescarmona E, Rendina EA, et al. True thymic hyperplasia: a clinicopathological study. Ann Thorac Surg 47: 741-745, 1989.","DOI":"10.1016\/0003-4975(89)90131-8"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Zhang K, Wu W, Wu Y, et al. Thymic lymphoid hyperplasia with Graves&apos; disease in a 28-year-old female: a case report. Gland Surg 9: 437-441, 2020.","DOI":"10.21037\/gs.2019.12.18"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Michie W, Gunn A. The thyroid, the thymus and autoimmunity. Br J Clin Pract 20: 9-13, 1966.","DOI":"10.1111\/j.1742-1241.1966.tb06944.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kotwal N, Singh Y, Menon A, et al. Thymic hyperplasia in Graves&apos; disease. Indian J Endocrinol Metab 17: 521-523, 2013.","DOI":"10.4103\/2230-8210.111676"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Judd R, Bueso-Ramos C. Combined true thymic hyperplasia and lymphoid hyperplasia in Graves&apos; disease. Pediatr Pathol 10: 829-836, 1990.","DOI":"10.3109\/15513819009064717"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Le Panse R, Bismuth J, Cizeron-Clairac G, et al. Thymic remodeling associated with hyperplasia in myasthenia gravis. Autoimmunity 43: 401-412, 2010.","DOI":"10.3109\/08916930903563491"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Dalla Costa M, Mangano FA, Betterle C. Thymic hyperplasia in patients with Graves&apos; disease. J Endocrinol Invest 37: 1175-1179, 2014.","DOI":"10.1007\/s40618-014-0157-7"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Murakami M, Hosoi Y, Negishi T, et al. Thymic hyperplasia in patients with Graves&apos; disease. Identification of thyrotropin receptors in human thymus. J Clin Invest 98: 2228-2234, 1996.","DOI":"10.1172\/JCI119032"},{"key":"17","first-page":"516","volume":"27","author":"JM Scheiff","year":"1977","unstructured":"17. Scheiff JM, Cordier AC, Haumont S. Epithelial cell proliferation in thymic hyperplasia induced by triiodothyronine. Clin Exp Immunol 27: 516-521, 1977.","journal-title":"Clinical & Experimental Immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Jinguji M, Nakajo M, Nakajo M, et al. Thymic involution after radioiodine therapy for Graves disease: relationships with serum thyroid hormones and TRAb. J Endocr Soc 1: 852-860, 2017.","DOI":"10.1210\/js.2017-00182"},{"key":"19","unstructured":"19. Mendelson DS. Imaging of the thymus. Chest Surg Clin N Am 11: 269-293, 2001."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Mariotti S, Caturegli P, Barbesino G, et al. Thyroid function and thyroid autoimmunity independently modulate serum concentration of soluble interleukin 2 (IL-2) receptor (sIL-2R) in thyroid diseases. Clin Endocrinol (Oxf) 3: 415-422, 1992.","DOI":"10.1111\/j.1365-2265.1992.tb02352.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Shimoda Y, Satoh T, Takahashi H, et al. A case of thyroid storm with a markedly elevated level of circulating soluble interleukin-2 receptor complicated by multiple organ failure and disseminated intravascular coagulation syndrome. Endocr J 61: 691-696, 2014.","DOI":"10.1507\/endocrj.EJ14-0073"}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/61\/18\/61_8710-21\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T05:20:01Z","timestamp":1715232001000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/61\/18\/61_8710-21\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,15]]},"references-count":21,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.8710-21","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,15]]},"article-number":"8710-21"}}