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Blumenthal GM, Dennis PA. PTEN hamartoma tumor syndromes. Eur J Hum Genet 16: 1289-1300, 2008."},{"key":"2","unstructured":"2. Lok C, Viseux V, Avril MF, et al. Brain magnetic resonance imaging in patients with Cowden syndrome. Medicine (Baltimore) 84: 129-136, 2005."},{"key":"3","unstructured":"3. Lloyd KM 2nd, Dennis M. Cowden's disease. A possible new symptom complex with multiple system involvement. Ann Intern Med 58: 136-142, 1963."},{"key":"4","unstructured":"4. Farooq A, Walker LJ, Bowling J, Audisio RA. Cowden syndrome. Cancer Treat Rev 36: 577-583, 2010."},{"key":"5","unstructured":"5. Nelen MR, Padberg GW, Peeters EA, et al. Localization of the gene for Cowden disease to chromosome 10q22-23. Nat Genet 13: 114-116, 1996."},{"key":"6","unstructured":"6. Shen WH, Balajee AS, Wang J, et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128: 157-170, 2007."},{"key":"7","unstructured":"7. Orrico A, Galli L, Buoni S, Orsi A, Vonella G, Sorrentino V. Novel PTEN mutations in neurodevelopmental disorders and macrocephaly. Clin Genet 75: 195-198, 2009."},{"key":"8","unstructured":"8. Cheung KM, Lam CW, Chan YK, Siu WK, Yong L. Atypical focal cortical dysplasia in a patient with Cowden syndrome. Hong Kong Med J 20: 165-167, 2014."},{"key":"9","unstructured":"9. Elia M, Amato C, Bottitta M, et al. An atypical patient with Cowden syndrome and PTEN gene mutation presenting with cortical malformation and focal epilepsy. Brain Dev 34: 873-876, 2012."},{"key":"10","unstructured":"10. Child ND, Cascino GD. Mystery case: Cowden syndrome presenting with partial epilepsy related to focal cortical dysplasia. Neurology 81: e98-e99, 2013."},{"key":"11","unstructured":"11. Rodgers SJ, Ferguson D, Mitchell C, Ooms L. Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases. Biosci Rep 2017 (Epub ahead of print)."},{"key":"12","unstructured":"12. Nguyen LH, Brewster AL, Clark ME, et al. mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia. Epilepsia 56: 636-646, 2015."},{"key":"13","unstructured":"13. Nakashima M, Saitsu H, Takei N, et al. Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb. 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