{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:00:36Z","timestamp":1792807236918,"version":"4.5.0"},"reference-count":43,"publisher":"Japanese Society of Internal Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern. Med."],"published-print":{"date-parts":[[2018]]},"DOI":"10.2169\/internalmedicine.9274-17","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T17:10:01Z","timestamp":1512666601000},"page":"301-310","source":"Crossref","is-referenced-by-count":18,"title":["Observational Study of Infective Endocarditis at a Community-based Hospital: Dominance of Elderly Patients with Comorbidity"],"prefix":"10.2169","volume":"57","author":[{"given":"Tomoo","family":"Nagai","sequence":"first","affiliation":[{"name":"Department of Cardiology, Japan Self-Defense Forces Central Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Takase","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Japan Self-Defense Forces Central Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hamabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Japan Self-Defense Forces Central Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Japan Self-Defense Forces Central Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"962","reference":[{"key":"1","unstructured":"1. Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380: 2197-2223, 2012."},{"key":"2","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIR.0000000000000296","volume":"132","author":"LM Baddour","year":"2015","unstructured":"2. Baddour LM, Wilson WR, Bayer AS, et al.; American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals from the American Heart Association. Circulation 132: 1435-1486, 2015.","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Hoen B, Duval X. Infective endocarditis. N Engl J Med 368: 1425-1433, 2013.","DOI":"10.1056\/NEJMcp1206782"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Delahaye F. Is early surgery beneficial in infective endocarditis? A systematic review. Arch Cardiovasc Dis 104: 35-44, 2011.","DOI":"10.1016\/j.acvd.2010.11.003"},{"key":"5","unstructured":"5. Tleyjeh IM, Kashour T, Zimmerman V, Steckelberg JM, Wilson WR, Baddour LM. The role of valve surgery in infective endocarditis management: a systematic review of observational studies that included propensity score analysis. Am Heart J 156: 901-909, 2008."},{"key":"6","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/CIRCULATIONAHA.109.864488","volume":"121","author":"T Lalani","year":"2010","unstructured":"6. Lalani T, Cabell CH, Benjamin DK, et al.; International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators. Analysis of the impact of early surgery on in-hospital mortality of native valve endocarditis: use of propensity score and instrumental variable methods to adjust for treatment-selection bias. Circulation 121: 1005-1013, 2010.","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kiefer T, Park L, Tribouilloy C, et al. Association between valvular surgery and mortality among patients with infective endocarditis complicated by heart failure. JAMA 306: 2239-2247, 2011.","DOI":"10.1001\/jama.2011.1701"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kang DH, Kim YJ, Kim SH, et al. Early surgery versus conventional treatment for infective endocarditis. N Engl J Med 366: 2466-2473, 2012.","DOI":"10.1056\/NEJMoa1112843"},{"key":"9","unstructured":"9. Nakatani S, Mitsutake K, Hozumi T, et al.; Committee on Guideline for Prevention and Management of Infective Endocarditis, Japanese Circulation Society. Current characteristics of infective endocarditis in Japan: an analysis of 848 cases in 2000 and 2001. Circ J 67: 901-905, 2003."},{"key":"10","unstructured":"10. Ako J, Ikari Y, Hatori M, Hara K, Ouchi Y. Changing spectrum of infective endocarditis: review of 194 episodes over 20 years. Circ J 67: 3-7, 2003."},{"key":"11","unstructured":"11. Hanai M, Hashimoto K, Mashiko K, et al. Active infective endocarditis: management and risk analysis of hospital death from 24 years' experience. Circ J 72: 2062-2068, 2008."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Fukuchi T, Iwata K, Ohji G. Failure of early diagnosis of infective endocarditis in Japan-a retrospective descriptive analysis. Medicine (Baltimore) 93: e237, 2014.","DOI":"10.1097\/MD.0000000000000237"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Nakatani S, Mitsutake K, Ohara T, Kokubo Y, Yamamoto H, Hanai S; CADRE Investigators. Recent picture of infective endocarditis in Japan-lessons from Cardiac Disease Registration (CADRE-IE). Circ J 77: 1558-1564, 2013.","DOI":"10.1253\/circj.CJ-12-1101"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Iung B, Cachier A, Baron G, et al. Decision-making in elderly patients with severe aortic stenosis: why are so many denied surgery? Eur Heart J 2714-2720, 2005.","DOI":"10.1093\/eurheartj\/ehi471"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Hu K, Wan Y, Hong T, et al. Therapeutic decision-making for elderly patients with symptomatic severe valvular heart diseases. Int Heart J 57: 434-440, 2016.","DOI":"10.1536\/ihj.16-027"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Edwards FH, Peterson ED, Coombs LP, et al. Prediction of operative mortality after valve replacement surgery. J Am Coll Cardiol 37: 885-892, 2001.","DOI":"10.1016\/S0735-1097(00)01202-X"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Afilalo J, Eisenberg MJ, Morin JF, et al. Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery. J Am Coll Cardiol 56: 1668-1676, 2010.","DOI":"10.1016\/j.jacc.2010.06.039"},{"key":"18","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/CIRCULATIONAHA.108.841437","volume":"121","author":"DH Lee","year":"2010","unstructured":"18. Lee DH, Buth KJ, Martin BJ, Yip AM, Hirsch GM. Frail patients are at increased risk for mortality and prolonged institutional care after cardiac surgery. Circulation 121: 973-978, 2010.","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Afilalo J, Mottillo S, Eisenberg MJ, et al. Addition of frailty and disability to cardiac surgery risk scores identifies elderly patients at high risk of mortality or major morbidity. Circ Cardiovasc Qual Outcomes 5: 222-228, 2012.","DOI":"10.1161\/CIRCOUTCOMES.111.963157"},{"key":"20","unstructured":"20. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40: 373-383, 1987."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Quan H, Li B, Couris CM, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol 173: 676-682, 2011.","DOI":"10.1093\/aje\/kwq433"},{"key":"22","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","volume":"185","author":"S Katz","year":"1963","unstructured":"22. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The Index of ADL: a standardized measure of biological and psychosocial function. JAMA 185: 914-919, 1963.","journal-title":"JAMA The Journal of the American Medical Association","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Horstkotte D, Follath F, Gutschik E, et al.; Task Force Members on Infective Endocarditis of the European Society of Cardiology, ESC Committee for Practice Guidelines (CPG), Document Reviewers. Guidelines on prevention, diagnosis and treatment of infective endocarditis executive summary; the task force on infective endocarditis of the European society of cardiology. Eur Heart J 25: 267-276, 2004.","DOI":"10.1016\/j.ehj.2003.11.008"},{"key":"24","unstructured":"24. Habib G, Lancellotti P, Antunes MJ, et al.; Document Reviewers. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J 36: 3075-3128, 2015."},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Baddour LM, Wilson WR, Bayer AS, et al.; Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association, Infectious Diseases Society of America. Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America. Circulation 111: e394-e434, 2005.","DOI":"10.1161\/CIRCULATIONAHA.105.165564"},{"key":"26","unstructured":"26. Durack DT, Lukes AS, Bright DK. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. Am J Med 96: 200-209, 1994."},{"key":"27","doi-asserted-by":"publisher","unstructured":"27. Fowler VG Jr, Miro JM, Hoen B, et al.; ICE Investigators. Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA 293: 3012-3021, 2005.","DOI":"10.1001\/jama.293.24.3012"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Nashef SA, Roques F, Sharples LD, et al. EuroSCORE II. Eur J Cardiothorac Surg 41: 734744, 2012.","DOI":"10.1093\/ejcts\/ezs043"},{"key":"29","unstructured":"29. Gaca JG, Sheng S, Daneshmand MA, et al. Outcomes for endocarditis surgery in North America: a simplified risk scoring system. J Thorac Cardiovasc Surg 141: 98-106.e1-e2, 2011."},{"key":"30","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1001\/jama.286.14.1754","volume":"286","author":"FL Ferreira","year":"2001","unstructured":"30. Ferreira FL, Bota DP, Bross A, et al.; AEPEI Study Group. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 286: 1754-1758, 2001.","journal-title":"JAMA The Journal of the American Medical Association","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"31","unstructured":"31. Selton-Suty C, C\u00e9lard M, Le Moing V, et al.; AEPEI Study Group. Preeminence of Staphylococcus aureus in infective endocarditis: a 1-year population-based survey. Clin Infect Dis 54: 1230-1239, 2012."},{"key":"32","unstructured":"32. Forestier E, Fraisse T, Roubaud-Baudron C, Selton-Suty C, Pagani L. Managing infective endocarditis in the elderly: new issues for an old disease. Clin Interv Aging 11: 1199-1206, 2016."},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Dhawan VK. Infective endocarditis in elderly patients. Curr Infect Dis Rep 5: 285-292, 2003.","DOI":"10.1007\/s11908-003-0004-z"},{"key":"34","unstructured":"34. Di Salvo G, Thuny F, Rosenberg V, et al. Endocarditis in the elderly: clinical, echocardiographic, and prognostic features. Eur Heart J 24: 1576-1583, 2003."},{"key":"35","unstructured":"35. Gregoratos G. Infective endocarditis in the elderly: diagnosis and management. Am J Geriatr Cardiol 12: 183-189, 2003."},{"key":"36","unstructured":"36. Remadi JP, Nadji G, Goissen T, Zomvuama NA, Sorel C, Tribouilloy C. Infective endocarditis in elderly patients: clinical characteristics and outcome. Eur J Cardiothorac Surg 35: 123-129, 2009."},{"key":"37","unstructured":"37. L\u00f3pez J, Revilla A, Vilacosta I, et al. Age-dependent profile of left-sided infective endocarditis: a 3-center experience. Circulation 121: 892-897, 2010."},{"key":"38","unstructured":"38. Durante-Mangoni E, Bradley S, Selton-Suty C, et al.; International Collaboration on Endocarditis Prospective Cohort Study Group. Current features of infective endocarditis in elderly patients: results of the International Collaboration on Endocarditis Prospective Cohort Study. Arch Intern Med 168: 2095-2103, 2008."},{"key":"39","unstructured":"39. Ram\u00edrez-Duque N, Garc\u00eda-Cabrera E, Ivanova-Georgieva R, et al.; Grupo para el Estudio de las Infecciones Cardiovasculares de la Sociedad Andaluza de Enfermedades Infecciosas (SAEI). Surgical treatment for infective endocarditis in elderly patients. J Infect 63: 131-138, 2011."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Wang TK, Oh T, Voss J, Gamble G, Kang N, Pemberton J. Comparison of contemporary risk scores for predicting outcomes after surgery for active infective endocarditis. Heart Vessels 30: 227-234, 2015.","DOI":"10.1007\/s00380-014-0472-0"},{"key":"41","unstructured":"41. Freeman WK, Schaff HV, O'Brien PC, Orszulak TA, Naessens JM, Tajik AJ. Cardiac surgery in the octogenarian: perioperative outcome and clinical follow-up. J Am Coll Cardiol 18: 29-35, 1991."},{"key":"42","unstructured":"42. Bouma BJ, van den Brink RBA, van der Meulen JHP, et al. To operate or not on elderly patients with aortic stenosis: the decision and its consequences. Heart 82: 143-148, 1999."},{"key":"43","unstructured":"43. Bach DS, Siao D, Girard SE, Duvernoy C, McCallister BD Jr, Gualano SK. Evaluation of patients with severe symptomatic aortic stenosis who do not undergo aortic valve replacement: the potential role of subjectively overestimated operative risk. Circ Cardiovasc Qual Outcomes 2: 533-539, 2009."}],"container-title":["Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/57\/3\/57_9274-17\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T13:32:45Z","timestamp":1570455165000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/57\/3\/57_9274-17\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.2169\/internalmedicine.9274-17","relation":{},"ISSN":["0918-2918","1349-7235"],"issn-type":[{"value":"0918-2918","type":"print"},{"value":"1349-7235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}