{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:27:41Z","timestamp":1760866061648,"version":"3.40.4"},"reference-count":0,"publisher":"Skyler Publication","issue":"2","license":[{"start":{"date-parts":[[2017,4,15]],"date-time":"2017-04-15T00:00:00Z","timestamp":1492214400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neonat Surg"],"abstract":"<jats:p>AIM: To determine the beneficial effects of Glutamine, Psyllium, Short Chain Fatty Acids (SCFA), and Maharishi Amrit Kalash (MAK), in preventing the histological changes after diversion colostomy.MATERIAL AND METHODS: After ethical clearance, male wistar rats (n=40) underwent diversion colostomy. Rats were divided into five groups of 8 rats each. Each group was given, after diversion colostomy, per rectally, one of the five agents being tested as an enema (3 ml\/kg\/day). Group I: Normal saline. Group II: Glutamine Group III: Psyllium, Group IV: MAK. Group V: Short chain fatty acid. The rats were euthanised 45 days after performing diversion colostomy. Morphometrical analysis of defunctionalised colon was done. Statistical analysis was done using SSPS statistical analysis software.RESULTS: On comparison with Group I epithelial cell height and mucosal thickness was significantly higher in Group II. Muscularis externae thickness was significantly higher in Group III on comparison with Group I. Group V had least inflammatory changes. CONCLUSIONS: Atrophic and inflammatory changes in the diverted colon can be prevented by per rectal administration of Glutamine, Psyllium and Short chain fatty acids.<\/jats:p>","DOI":"10.21699\/jns.v6i2.511","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T03:05:58Z","timestamp":1493694358000},"page":"26","source":"Crossref","is-referenced-by-count":2,"title":["Prevention of Histological Changes after Colonic Diversion in Rats: An Experimental Study"],"prefix":"10.63682","volume":"6","author":[{"given":"M","family":"Pathak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Srinivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Shariff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"53067","published-online":{"date-parts":[[2017,4,15]]},"container-title":["Journal of Neonatal Surgery"],"original-title":[],"link":[{"URL":"http:\/\/www.jneonatalsurg.com\/ojs\/index.php\/jns\/article\/viewFile\/511\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jneonatalsurg.com\/ojs\/index.php\/jns\/article\/viewFile\/511\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T22:24:21Z","timestamp":1745533461000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jneonatalsurg.com\/ojs\/index.php\/jns\/article\/view\/481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,15]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,4,15]]}},"URL":"https:\/\/doi.org\/10.21699\/jns.v6i2.511","relation":{},"ISSN":["2226-0439"],"issn-type":[{"type":"electronic","value":"2226-0439"}],"subject":[],"published":{"date-parts":[[2017,4,15]]}}}