{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:09:13Z","timestamp":1778846953211,"version":"3.51.4"},"reference-count":104,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PPL"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Tripartite motif-containing protein 44 (TRIM44), a unique member of the TRIM family\nthat lacks the canonical RING domain, has recently attracted significant attention for its broad\noncogenic potential across diverse malignancies. Accumulating evidence indicates that TRIM44 is\nmarkedly overexpressed in cancers, including colorectal, gastric, lung, breast, ovarian, and prostate\ncarcinomas, as well as glioblastoma, multiple myeloma, and hepatocellular carcinoma.\nMechanistically, TRIM44 drives tumor progression by modulating critical signaling pathways,\nincluding PI3K\/AKT\/mTOR, NF-&amp;#954;B, Wnt\/&amp;#946;-catenin, and epithelial\u2013mesenchymal transition\n(EMT), primarily through stabilizing regulatory proteins or participating in non-coding RNA\u2013\nmediated networks. In addition to its role in cancer, TRIM44 has been implicated in cardiovascular\ndysfunction, ischemia\u2013reperfusion injury, diabetic complications, and neuroinflammation,\nunderscoring its biological versatility. This review provides an overview of current evidence\nregarding the multifaceted roles of TRIM44 in both oncogenic and non-oncogenic diseases. By\nintegrating insights from oncology, cardiology, neurology, and metabolic research, this review\noffers a unified perspective on TRIM44 as a pivotal molecular hub and an emerging diagnostic and\ntherapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0109298665428424251216064630","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T19:23:34Z","timestamp":1774034614000},"page":"79-97","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRIM44 as a Multifunctional Regulator in Cancer and Non-Cancer Diseases: From Oncogenic Driver to Immune and Stress Response Modulator"],"prefix":"10.2174","volume":"33","author":[{"given":"Guive","family":"Sharifi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran"},{"name":"SkullBase, Shahid Beheshti University of Medical 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Cardiovascular Research Center, Shahid Sadoughi University of Medical Science, Yazd, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khatere","family":"Mokhtari","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology,University of Isfahan, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parnaz","family":"Mohseni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Iran University of Medical Science,Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanie","family":"Mahaki","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences,Mashhad, 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Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Hemmatyar","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Shohadaye Haftom-E-Tir Hospital, Department of Orthopaedics, School ofMedicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esmaeil","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tehran University of MedicalSciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tehran University of Medical Sciences, Hakim Hospital,Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Jahanshahi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Iran University of Medical Sciences, Tehran, 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