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Therefore, there is an urgent need to explore novel therapeutic\napproaches and develop new anti-tumor agents with low toxicity. With over 25,000 fish species and\none million marine invertebrates, the oceans represent an under-explored reservoir of bioactive\ncompounds, where marine anti-tumor peptides exhibit unique advantages including low intrinsic\ntoxicity, high tissue penetration, and specificity towards cancer cells that address critical limitations\nof chemotherapeutic drugs, such as off-target effects and multidrug resistance. However, the field\ncurrently lacks a comprehensive and systematic analyses that integrate recent advances in discovery,\nmechanistic elucidation, and translational challenges. This review covers key aspects such as\nisolation techniques, purification processes, structural characterization techniques, and diverse antitumor\nmechanisms. Its goal is to summarize and analyze the current state, trends, and research\nadvancements of anti-tumor peptides isolated and extracted from marine organisms. Additionally,\nthis review systematically compiles peptide structures with clinical potential and dissects the key\nobstacles in their drug development pathways. By integrating this knowledge, the review not only\nserves as a valuable reference for researchers but also offers critical insights into the strategic\nroadmap for harnessing marine peptides in the fight against cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0109298665451278260413074905","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:56:06Z","timestamp":1777550166000},"page":"422-438","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolation, Structures, and Mechanisms of Anti-Tumor Peptides from Marine Organisms: A Review"],"prefix":"10.2174","volume":"33","author":[{"given":"Xueer","family":"Xu","sequence":"first","affiliation":[{"name":"Dongguan Key Laboratory of Traditional Chinese Medicines for Prevention and Treatment of Digestive Diseases,Guangdong Medical University, Dongguan, Guangdong, 523808, China"},{"name":"School of Medical Technology, GuangdongMedical University, Dongguan, Guangdong, 523808, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahua","family":"Peng","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Traditional Chinese Medicines for Prevention and Treatment of Digestive Diseases,Guangdong Medical University, Dongguan, Guangdong, 523808, China"},{"name":"School of Pharmacy, Guangdong Medical University,Dongguan, Guangdong, 523808, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shi","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Traditional Chinese Medicines for Prevention and Treatment of Digestive Diseases,Guangdong Medical University, Dongguan, Guangdong, 523808, China"},{"name":"School of Pharmacy, Guangdong Medical University,Dongguan, Guangdong, 523808, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"Bray F.","year":"2024","unstructured":"Bray F.; Laversanne M.; Sung H.; Ferlay J.; Siegel R.L.; Soerjomataram I.; Jemal A.; Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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