{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:21:58Z","timestamp":1791400918379,"version":"4.3.3"},"reference-count":183,"publisher":"Bentham Science Publishers Ltd.","issue":"13","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The escalating global burden of stress and depression underscores\nan urgent need to unravel their complex interrelationships and underlying mechanisms.\nThis investigation delves into the intricate dynamics between stress and depression,\nspotlighting the Neuroimmunoinflammatory Stress Model (NIIS), which elucidates\nthe pivotal role of cellular and molecular pathways in mediating these conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Through an exhaustive review of literature spanning epidemiology, neurobiology,\nand psychoneuroimmunology, this study synthesizes the current understanding of\nstress and depression. It accentuates the definitional scopes, interplay, and intricacies of\nthe NIIS model, which integrates neuroimmune-inflammatory responses into the conceptual\nframework of the stress-depression interaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>By identifying stress as a multifactorial reaction to perceived adversities and depression\nas a manifestation of prolonged stress exposure, our analysis foregrounds the\nNIIS model. This paradigmatic model reveals the transition from normal stress responses\nto pathological neuroinflammatory pathways, highlighting neurotransmitter imbalances,\ndisruptions in neuronal and glial homeostasis, and ensuing low-grade neuroinflammation\nas key factors in the pathogenesis of depression under chronic stress conditions.\nThe NIIS model identifies prolonged cellular pro-inflammatory stress of neurons\nand microglia as a fundamental pathological subsystem of many neuropsychiatric disorders.\nIn turn, neuroinflammation and associated neurodegenerative processes are complications\nof chronic psychoemotional stress, which can clinically manifest as depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The NIIS model views depression as the terminal stage of chronic stress,\npathogenetically linked to latent neuroinflammation. This insight not only advances our\nunderstanding of their etiopathogenesis but also paves the way for developing precise\ntherapeutic interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0109298673320710240920055041","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T02:21:05Z","timestamp":1727749265000},"page":"2523-2546","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neuroimmune Interactions in Stress and Depression: Exploring the Molecular and Cellular Mechanisms within the Neuroinflammation-depression Nexus"],"prefix":"10.2174","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-9655","authenticated-orcid":true,"given":"Alexey","family":"Sarapultsev","sequence":"first","affiliation":[{"name":"Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Science, Ekaterinburg,620049, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7145-2376","authenticated-orcid":true,"given":"Evgenii","family":"Gusev","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Science, Ekaterinburg,620049, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4329-147X","authenticated-orcid":true,"given":"Valeriy","family":"Chereshnev","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Science, Ekaterinburg,620049, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-8358","authenticated-orcid":true,"given":"Maria","family":"Komelkova","sequence":"additional","affiliation":[{"name":"Russian-Chinese Education and Research Center of System Pathology, South Ural StateUniversity, Chelyabinsk, 454080, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and WesternMedicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, 430022, China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, TongjiMedical College, Huazhong University of Science and Technology, Wuhan, 430022, China"},{"name":"China-RussiaMedical Research Center for Stress Immunology, Union Hospital, Tongji Medical College, Huazhong Universityof Science and Technology, Wuhan, 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.psyneuen.2007.03.019","volume":"32","author":"Le Moal M.","year":"2007","unstructured":"Le Moal M.; Historical approach and evolution of the stress concept: A personal account. Psychoneuroendocrinology  2007,32(Suppl. 1),S3-S9","journal-title":"Psychoneuroendocrinology"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.psyneuen.2005.03.013","volume":"30","author":"Levine S.","year":"2005","unstructured":"Levine S.; Developmental determinants of sensitivity and resistance to stress. Psychoneuroendocrinology  2005,30(10),939-946","journal-title":"Psychoneuroendocrinology"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1177\/1745691616646305","volume":"11","author":"Cohen S.","year":"2016","unstructured":"Cohen S.; Gianaros P.J.; Manuck S.B.; A Stage Model of Stress and Disease. Perspect Psychol Sci  2016,11(4),456-463","journal-title":"Perspect Psychol Sci"},{"key":"ref=4","author":"Selye H.","year":"2007","unstructured":"Selye H.;  Stress in Health and Disease  \n https:\/\/shop.elsevier.com\/books\/stress-in-health-and-disease\/selye\/978-0-407-98510-0\n2007","journal-title":"Stress in Health and Disease"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1146\/annurev.clinpsy.1.102803.144141","volume":"1","author":"Schneiderman N.","year":"2005","unstructured":"Schneiderman N.; Ironson G.; Siegel S.D.; Stress and health: psychological, behavioral, and biological determinants. Annu Rev Clin Psychol  2005,1(1),607-628","journal-title":"Annu Rev Clin Psychol"},{"key":"ref=6","first-page":"3","author":"Levine S.","year":"1991","unstructured":"Levine S.; Ursin H.;  Stress: neurobiology and neuroendocrinology  1991,3-21","journal-title":"Stress: neurobiology and neuroendocrinology"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S0018-506X(02)00024-7","volume":"43","author":"McEwen B.S.","year":"2003","unstructured":"McEwen B.S.; Wingfield J.C.; The concept of allostasis in biology and biomedicine. Horm Behav  2003,43(1),2-15","journal-title":"Horm Behav"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/S0306-4530(03)00091-X","volume":"29","author":"Ursin H.","year":"2004","unstructured":"Ursin H.; Eriksen H.R.; The cognitive activation theory of stress. Psychoneuroendocrinology  2004,29(5),567-592","journal-title":"Psychoneuroendocrinology"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.yhbeh.2008.12.009","volume":"55","author":"Romero L.M.","year":"2009","unstructured":"Romero L.M.; Dickens M.J.; Cyr N.E.; The reactive scope model - a new model integrating homeostasis, allostasis, and stress. Horm Behav  2009,55(3),375-389","journal-title":"Horm Behav"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1016\/j.neubiorev.2011.02.003","volume":"35","author":"Koolhaas J.M.","year":"2011","unstructured":"Koolhaas J.M.; Bartolomucci A.; Buwalda B.; de Boer S.F.; Fl\u00fcgge G.; Korte S.M.; Meerlo P.; Murison R.; Olivier B.; Palanza P.; Richter-Levin G.; Sgoifo A.; Steimer T.; Stiedl O.; van Dijk G.; W\u00f6hr M.; Fuchs E.; Stress revisited: A critical evaluation of the stress concept. Neurosci Biobehav Rev  2011,35(5),1291-1301","journal-title":"Neurosci Biobehav Rev"},{"key":"ref=11","first-page":"629","author":"Sterling P.","year":"1988","unstructured":"Sterling P.; Eyer J.;  Handbook of life stress, cognition and health  1988,629-649","journal-title":"Handbook of life stress, cognition and health"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1007\/978-1-4419-1005-9_215","author":"Folkman S.","year":"2020","unstructured":"Folkman S.;  Encyclopedia of Behavioral Medicine  2020,2177-2179","journal-title":"Encyclopedia of Behavioral Medicine"},{"key":"ref=13","first-page":"456","author":"Lazarus R.S.","year":"1984","unstructured":"Lazarus R.S.; Folkman S.;  Stress, appraisal, and coping  1984,456","journal-title":"Stress, appraisal, and coping"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3389\/fgene.2012.00222","volume":"3","author":"Kagias K.","year":"2012","unstructured":"Kagias K.; Nehammer C.; Pocock R.; Neuronal responses to physiological stress. Front Genet  2012,3,222","journal-title":"Front Genet"},{"key":"ref=15","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1134\/S0026893320050118","volume":"54","author":"Ushakova V.M.","year":"2020","unstructured":"Ushakova V.M.; Morozova A.Y.; Reznik A.M.; Kostyuk G.P.; Chekhonin V.P.; Molecular biological aspects of depressive disorders: A modern view. Mol Biol (Mosk)  2020,54(5),725-749","journal-title":"Mol Biol (Mosk)"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","volume":"34","author":"Nestler E.J.","year":"2002","unstructured":"Nestler E.J.; Barrot M.; DiLeone R.J.; Eisch A.J.; Gold S.J.; Monteggia L.M.; Neurobiology of depression. Neuron  2002,34(1),13-25","journal-title":"Neuron"},{"key":"ref=17","year":"2013","unstructured":"Diagnostic and statistical manual of mental disorders: DSM-5  5, (5).2013","journal-title":"Diagnostic and statistical manual of mental disorders: DSM-5"},{"key":"ref=18","author":"Beck A.T.","year":"1967","unstructured":"Beck A.T.;  Depression  1967","journal-title":"Depression"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1146\/annurev.psych.48.1.191","volume":"48","author":"Kessler R.C.","year":"1997","unstructured":"Kessler R.C.; The effects of stressful life events on depression. Annu Rev Psychol  1997,48(1),191-214","journal-title":"Annu Rev Psychol"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S0006-3223(00)00964-1","volume":"48","author":"McEwen B.S.","year":"2000","unstructured":"McEwen B.S.; Effects of adverse experiences for brain structure and function. Biol Psychiatry  2000,48(8),721-731","journal-title":"Biol Psychiatry"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/1741-7015-11-200","volume":"11","author":"Berk M.","year":"2013","unstructured":"Berk M.; Williams L.J.; Jacka F.N.; O\u2019Neil A.; Pasco J.A.; Moylan S.; Allen N.B.; Stuart A.L.; Hayley A.C.; Byrne M.L.; Maes M.; So depression is an inflammatory disease, but where does the inflammation come from? BMC Med  2013,11(1),200","journal-title":"BMC Med"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.neubiorev.2011.12.005","volume":"36","author":"Leonard B.","year":"2012","unstructured":"Leonard B.; Maes M.; Mechanistic explanations how cell- mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev  2012,36(2),764-785","journal-title":"Neurosci Biobehav Rev"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0278-5846(94)00101-M","volume":"19","author":"Maes M.","year":"1995","unstructured":"Maes M.; Evidence for an immune response in major depression: A review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry  1995,19(1),11-38","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.ibror.2018.04.001","volume":"4","author":"Richter-Levin G.","year":"2018","unstructured":"Richter-Levin G.; Xu L.; How could stress lead to major depressive disorder? IBRO Rep  2018,4,38-43","journal-title":"IBRO Rep"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1176\/appi.neuropsych.15030053","volume":"28","author":"Tafet G.E.","year":"2016","unstructured":"Tafet G.E.; Nemeroff C.B.; The links between stress and depression: Psychoneuroendocrinological, genetic, and environmental interactions. J Neuropsychiatry Clin Neurosci  2016,28(2),77-88","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/S0893-133X(99)00129-3","volume":"22","author":"McEwen B.","year":"2000","unstructured":"McEwen B.; Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology  2000,22(2),108-124","journal-title":"Neuropsychopharmacology"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.neubiorev.2009.10.002","volume":"35","author":"Juster R.P.","year":"2010","unstructured":"Juster R.P.; McEwen B.S.; Lupien S.J.; Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev  2010,35(1),2-16","journal-title":"Neurosci Biobehav Rev"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1097\/PSY.0000000000000095","volume":"76","author":"Gallo L.C.","year":"2014","unstructured":"Gallo L.C.; Fortmann A.L.; Mattei J.; Allostatic load and the assessment of cumulative biological risk in biobehavioral medicine: challenges and opportunities. Psychosom Med  2014,76(7),478-480","journal-title":"Psychosom Med"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1111\/cns.12835","volume":"24","author":"Zhang F.F.","year":"2018","unstructured":"Zhang F.F.; Peng W.; Sweeney J.A.; Jia Z.Y.; Gong Q.Y.; Brain structure alterations in depression: Psychoradiological evidence. CNS Neurosci Ther  2018,24(11),994-1003","journal-title":"CNS Neurosci Ther"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.3389\/fnhum.2014.01045","volume":"8","author":"Palmer S.M.","year":"2015","unstructured":"Palmer S.M.; Crewther S.G.; Carey L.M.; A meta-analysis of changes in brain activity in clinical depression. Front Hum Neurosci  2015,8,1045","journal-title":"Front Hum Neurosci"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"5204","DOI":"10.3390\/jcm10215204","volume":"10","author":"Dziurkowska E.","year":"2021","unstructured":"Dziurkowska E.; Wesolowski M.; Cortisol as a biomarker of mental disorder severity. J Clin Med  2021,10(21),5204","journal-title":"J Clin Med"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.3390\/cells12232726","volume":"12","author":"Knezevic E.","year":"2023","unstructured":"Knezevic E.; Nenic K.; Milanovic V.; Knezevic N.N.; The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders. Cells  2023,12(23),2726","journal-title":"Cells"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jad.2017.09.052","volume":"233","author":"Juruena M.F.","year":"2018","unstructured":"Juruena M.F.; Bocharova M.; Agustini B.; Young A.H.; Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review. J Affect Disord  2018,233,45-67","journal-title":"J Affect Disord"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jsbmb.2019.04.006","volume":"190","author":"Berger I.","year":"2019","unstructured":"Berger I.; Werdermann M.; Bornstein S.R.; Steenblock C.; The adrenal gland in stress \u2013 adaptation on a cellular level. J Steroid Biochem Mol Biol  2019,190,198-206","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.jad.2020.12.200","volume":"282","author":"Kendler K.S.","year":"2021","unstructured":"Kendler K.S.; Kraepelin\u2019s final views on manic-depressive Illness. J Affect Disord  2021,282,979-990","journal-title":"J Affect Disord"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.semcancer.2012.02.008","volume":"22","author":"Kanterman J.","year":"2012","unstructured":"Kanterman J.; Sade-Feldman M.; Baniyash M.; New insights into chronic inflammation-induced immunosuppression. Semin Cancer Biol  2012,22(4),307-318","journal-title":"Semin Cancer Biol"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3390\/ijms24021144","volume":"24","author":"Zotova N.","year":"2023","unstructured":"Zotova N.; Zhuravleva Y.; Chereshnev V.; Gusev E.; Acute and chronic systemic inflammation: Features and differences in the pathogenesis, and integral criteria for verification and differentiation. Int J Mol Sci  2023,24(2),1144","journal-title":"Int J Mol Sci"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3390\/pathophysiology30010006","volume":"30","author":"Brazhnikov A.","year":"2023","unstructured":"Brazhnikov A.; Zotova N.; Solomatina L.; Sarapultsev A.; Spirin A.; Gusev E.; Shock-associated systemic inflammation in amniotic fluid embolism, complicated by clinical death. Pathophysiology  2023,30(1),48-62","journal-title":"Pathophysiology"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1752-4458-8-41","volume":"8","author":"Wang X.","year":"2014","unstructured":"Wang X.; Cai L.; Qian J.; Peng J.; Social support moderates stress effects on depression. Int J Ment Health Syst  2014,8(1),41","journal-title":"Int J Ment Health Syst"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"494","DOI":"10.2174\/1570159X1304150831150507","volume":"13","author":"Yang L.","year":"2015","unstructured":"Yang L.; Zhao Y.; Wang Y.; Liu L.; Zhang X.; Li B.; Cui R.; The effects of psychological stress on depression. Curr Neuropharmacol  2015,13(4),494-504","journal-title":"Curr Neuropharmacol"},{"key":"ref=41","first-page":"155","volume":"12","author":"Selye H.","year":"1953","unstructured":"Selye H.; The part of inflammation in the local adaptation syndrome. Rev Can Biol  1953,12(2),155-175","journal-title":"Rev Can Biol"},{"key":"ref=42","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.2174\/1381612823666170622110046","volume":"23","author":"Szabo S.","year":"2017","unstructured":"Szabo S.; Yoshida M.; Filakovszky J.; Juhasz G.; \u201cStress\u201d is 80 years old: From hans selye original paper in 1936 to recent advances in GI ulceration. Curr Pharm Des  2017,23(27),4029-4041","journal-title":"Curr Pharm Des"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3109\/10253890.2012.710919","volume":"15","author":"Szabo S.","year":"2012","unstructured":"Szabo S.; Tache Y.; Somogyi A.; The legacy of Hans Selye and the origins of stress research: A retrospective 75 years after his landmark brief \u201cLetter\u201d to the Editor  of Nature. Stress  2012,15(5),472-478","journal-title":"Stress"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"104284","DOI":"10.1016\/j.ebiom.2022.104284","volume":"84","author":"Van den Berghe G.","year":"2022","unstructured":"Van den Berghe G.; T\u00e9blick A.; Langouche L.; Gunst J.; The hypothalamus-pituitary-adrenal axis in sepsis- and hyperinflammation-induced critical illness: Gaps in current knowledge and future translational research directions. EBioMedicine  2022,84,104284","journal-title":"EBioMedicine"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1159\/000336803","volume":"81","author":"Maes M.","year":"2012","unstructured":"Maes M.; Twisk F.N.M.; Ringel K.; Inflammatory and cell-mediated immune biomarkers in myalgic encephalomyelitis\/chronic fatigue syndrome and depression: inflammatory markers are higher in myalgic encephalomyelitis\/chronic fatigue syndrome than in depression. Psychother Psychosom  2012,81(5),286-295","journal-title":"Psychother Psychosom"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"16668","DOI":"10.3390\/ijms242316668","volume":"24","author":"Wolff L.","year":"2023","unstructured":"Wolff L.; Horisberger A.; Moi L.; Karampetsou M.P.; Comte D.; Polyarteritis nodosa: Old disease, new etiologies. Int J Mol Sci  2023,24(23),16668","journal-title":"Int J Mol Sci"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"101118","DOI":"10.1016\/j.eclinm.2021.101118","volume":"40","author":"Kiriella D.A.","year":"2021","unstructured":"Kiriella D.A.; Islam S.; Oridota O.; Sohler N.; Dessenne C.; de Beaufort C.; Fagherazzi G.; Aguayo G.A.; Unraveling the concepts of distress, burnout, and depression in type 1 diabetes: A scoping review. EClinicalMedicine  2021,40,101118","journal-title":"EClinicalMedicine"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"14646","DOI":"10.1002\/cam4.6069","volume":"12","author":"Tan K.P.","year":"2023","unstructured":"Tan K.P.; Talaulikar D.; Scholz B.; Factors of emotional distress in lymphoma: A systematic review. Cancer Med  2023,12(13),14646-14662","journal-title":"Cancer Med"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"11453","DOI":"10.3390\/ijms222111453","volume":"22","author":"Gusev E.","year":"2021","unstructured":"Gusev E.; Solomatina L.; Zhuravleva Y.; Sarapultsev A.; The pathogenesis of end-stage renal disease from the standpoint of the theory of general pathological processes of inflammation. Int J Mol Sci  2021,22(21),11453","journal-title":"Int J Mol Sci"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"4596","DOI":"10.3390\/ijms23094596","volume":"23","author":"Gusev E.","year":"2022","unstructured":"Gusev E.; Zhuravleva Y.; Inflammation: A new look at an old problem. Int J Mol Sci  2022,23(9),4596","journal-title":"Int J Mol Sci"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-981-10-5987-2_6","volume":"1024","author":"Yao X.","year":"2017","unstructured":"Yao X.; Meng G.; Inflammasomes in the gut mucosal homeostasis. Adv Exp Med Biol  2017,1024,133-151","journal-title":"Adv Exp Med Biol"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1001\/jama.1992.03480090092034","volume":"267","author":"Chrousos G.P.","year":"1992","unstructured":"Chrousos G.P.; Gold P.W.; The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA  1992,267(9),1244-1252","journal-title":"JAMA"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0018-506X(02)00035-1","volume":"43","author":"Schulkin J.","year":"2003","unstructured":"Schulkin J.; Allostasis: A neural behavioral perspective. Horm Behav  2003,43(1),21-27","journal-title":"Horm Behav"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1146\/annurev-psych-062520-122331","volume":"72","author":"O\u2019Connor D.B.","year":"2021","unstructured":"O\u2019Connor D.B.; Thayer J.F.; Vedhara K.; Stress and health: A review of psychobiological processes. Annu Rev Psychol  2021,72(1),663-688","journal-title":"Annu Rev Psychol"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/1359105319842931","volume":"25","author":"Barry V.","year":"2020","unstructured":"Barry V.; Stout M.E.; Lynch M.E.; Mattis S.; Tran D.Q.; Antun A.; Ribeiro M.J.A.; Stein S.F.; Kempton C.L.; The effect of psychological distress on health outcomes: A systematic review and meta-analysis of prospective studies. J Health Psychol  2020,25(2),227-239","journal-title":"J Health Psychol"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"1900238","DOI":"10.1002\/bies.201900238","volume":"42","author":"Bienertova-Vasku J.","year":"2020","unstructured":"Bienertova-Vasku J.; Lenart P.; Scheringer M.; Eustress and distress: Neither good nor bad, but rather the same? BioEssays  2020,42(7),1900238","journal-title":"BioEssays"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1093\/eurjcn\/zvad005","volume":"22","author":"Kim B.","year":"2023","unstructured":"Kim B.; Park H.; The effects of auricular acupressure on blood pressure, stress, and sleep in elders with essential hypertension: A randomized single-blind sham-controlled trial. Eur J Cardiovasc Nurs  2023,22(6),610-619","journal-title":"Eur J Cardiovasc Nurs"},{"key":"ref=58","first-page":"112","volume":"35","author":"Urmancheva T.G.","year":"1986","unstructured":"Urmancheva T.G.; Fufacheva A.A.; Capek K.; Kunes J.; Jel\u00ednek J.; Blood pressure in monkeys chronically exposed to psycho-emotional stress. Physiol Bohemoslov  1986,35(2),112-117","journal-title":"Physiol Bohemoslov"},{"key":"ref=59","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4088\/JCP.v61n0405","volume":"61","author":"Hirschfeld R.M.","year":"2000","unstructured":"Hirschfeld R.M.; History and evolution of the monoamine hypothesis of depression. J Clin Psychiatry  2000,61(Suppl. 6),4-6","journal-title":"J Clin Psychiatry"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1055\/s-2007-979535","volume":"29","author":"Heninger G.","year":"1996","unstructured":"Heninger G.; Delgado P.; Charney D.; The revised monoamine theory of depression: A modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans. Pharmacopsychiatry  1996,29(1),2-11","journal-title":"Pharmacopsychiatry"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.socscimed.2010.12.005","volume":"72","author":"Keyes K.M.","year":"2011","unstructured":"Keyes K.M.; Barnes D.M.; Bates L.M.; Stress, coping, and depression: Testing a new hypothesis in a prospectively studied general population sample of U.S.-born Whites and Blacks. Soc Sci Med  2011,72(5),650-659","journal-title":"Soc Sci Med"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00441-003-0807-0","volume":"315","author":"Fl\u00fcgge G.","year":"2004","unstructured":"Fl\u00fcgge G.; van Kampen M.; Mijnster M.J.; Perturbations in brain monoamine systems during stress. Cell Tissue Res  2004,315(1),1-14","journal-title":"Cell Tissue Res"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1503\/jpn.150028","volume":"41","author":"Isingrini E.","year":"2016","unstructured":"Isingrini E.; Perret L.; Rainer Q.; Sagueby S.; Moquin L.; Gratton A.; Giros B.; Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour. J Psychiatry Neurosci  2016,41(3),169-181","journal-title":"J Psychiatry Neurosci"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"30187","DOI":"10.1038\/srep30187","volume":"6","author":"Qin D.","year":"2016","unstructured":"Qin D.; Rizak J.; Feng X.; Yang S.; L\u00fc L.; Pan L.; Yin Y.; Hu X.; Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour. Sci Rep  2016,6(1),30187","journal-title":"Sci Rep"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1192\/bjp.180.2.99","volume":"180","author":"Cowen P.J.","year":"2002","unstructured":"Cowen P.J.; Cortisol, serotonin and depression: All stressed out? Br J Psychiatry  2002,180(2),99-100","journal-title":"Br J Psychiatry"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/s41398-023-02514-2","volume":"13","author":"Cutler A.J.","year":"2023","unstructured":"Cutler A.J.; Mattingly G.W.; Maletic V.; Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder. Transl Psychiatry  2023,13(1),228","journal-title":"Transl Psychiatry"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/bs.apha.2014.11.003","volume":"73","author":"Luscher B.","year":"2015","unstructured":"Luscher B.; Fuchs T.; GABAergic control of depression-related brain states. Adv Pharmacol  2015,73,97-144","journal-title":"Adv Pharmacol"},{"key":"ref=68","doi-asserted-by":"crossref","first-page":"F1000","DOI":"10.12688\/f1000research.18758.1","volume":"8","author":"L\u00fcscher B.","year":"2019","unstructured":"L\u00fcscher B.; M\u00f6hler H.; a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience. F1000Res  2019,8,F1000","journal-title":"F1000Res"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s12264-021-00638-3","volume":"37","author":"Li Z.","year":"2021","unstructured":"Li Z.; Ruan M.; Chen J.; Fang Y.; Major depressive disorder: Advances in neuroscience research and translational applications. Neurosci Bull  2021,37(6),863-880","journal-title":"Neurosci Bull"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"107653","DOI":"10.1016\/j.intimp.2021.107653","volume":"97","author":"Wu Z.","year":"2021","unstructured":"Wu Z.; Xiao L.; Wang H.; Wang G.; Neurogenic hypothesis of positive psychology in stress-induced depression: Adult hippocampal neurogenesis, neuroinflammation, and stress resilience. Int Immunopharmacol  2021,97,107653","journal-title":"Int Immunopharmacol"},{"key":"ref=71","first-page":"837","volume":"74","author":"Zhang Q.","year":"2022","unstructured":"Zhang Q.; Xu S.J.; Contributions of impaired adult hippocampal neurogenesis to occurrence and development of diabetic encephalopathy. Sheng Li Xue Bao  2022,74(5),837-842","journal-title":"Sheng Li Xue Bao"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"110151","DOI":"10.1016\/j.pnpbp.2020.110151","volume":"108","author":"Carniel B.P.","year":"2021","unstructured":"Carniel B.P.; da Rocha N.S.; Brain-derived neurotrophic factor (BDNF) and inflammatory markers: Perspectives for the management of depression. Prog Neuropsychopharmacol Biol Psychiatry  2021,108,110151","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"742","DOI":"10.3390\/ph16050742","volume":"16","author":"Borsellino P.","year":"2023","unstructured":"Borsellino P.; Krider R.I.; Chea D.; Grinnell R.; Vida T.A.; Ketamine and the disinhibition hypothesis: Neurotrophic factor-mediated treatment of depression. Pharmaceuticals (Basel)  2023,16(5),742","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nm.4050","volume":"22","author":"Duman R.S.","year":"2016","unstructured":"Duman R.S.; Aghajanian G.K.; Sanacora G.; Krystal J.H.; Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med  2016,22(3),238-249","journal-title":"Nat Med"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"101922","DOI":"10.1016\/j.cpr.2020.101922","volume":"82","author":"Nielsen J.D.","year":"2020","unstructured":"Nielsen J.D.; Mennies R.J.; Olino T.M.; Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth. Clin Psychol Rev  2020,82,101922","journal-title":"Clin Psychol Rev"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1126\/science.847460","volume":"196","author":"Engel G.L.","year":"1977","unstructured":"Engel G.L.; The need for a new medical model: A challenge for biomedicine. Science  1977,196(4286),129-136","journal-title":"Science"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1037\/0003-066X.59.8.676","volume":"59","author":"Cohen S.","year":"2004","unstructured":"Cohen S.; Social relationships and health. Am Psychol  2004,59(8),676-684","journal-title":"Am Psychol"},{"key":"ref=78","first-page":"253","author":"Cohen S.","year":"1984","unstructured":"Cohen S.; McKay G.;   1984,253-267"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1037\/0021-843X.86.2.103","volume":"86","author":"Zubin J.","year":"1977","unstructured":"Zubin J.; Spring B.; Vulnerability: A new view of schizophrenia. J Abnorm Psychol  1977,86(2),103-126","journal-title":"J Abnorm Psychol"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1177\/2470547017692328","volume":"1","author":"McEwen B.S.","year":"2017","unstructured":"McEwen B.S.; Neurobiological and systemic effects of chronic stress. Chronic Stress (Thousand Oaks)  2017,1,1648-1652","journal-title":"Chronic Stress (Thousand Oaks)"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ynstr.2017.03.001","volume":"7","author":"Foster J.A.","year":"2017","unstructured":"Foster J.A.; Rinaman L.; Cryan J.F.; Stress and the gut-brain axis: Regulation by the microbiome. Neurobiol Stress  2017,7,124-136","journal-title":"Neurobiol Stress"},{"key":"ref=82","first-page":"28","volume":"17","author":"Appleton J.","year":"2018","unstructured":"Appleton J.; The Gut-brain axis: Influence of microbiota on mood and mental health. Integr Med (Encinitas)  2018,17(4),28-32","journal-title":"Integr Med (Encinitas)"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"1151478","DOI":"10.3389\/fnins.2023.1151478","volume":"17","author":"Tan H.E.","year":"2023","unstructured":"Tan H.E.; The microbiota-gut-brain axis in stress and depression. Front Neurosci  2023,17,1151478","journal-title":"Front Neurosci"},{"key":"ref=84","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1176\/appi.ajp.2020.19111213","volume":"177","author":"Kendler K.S.","year":"2020","unstructured":"Kendler K.S.; A prehistory of the diathesis-stress model: Predisposing and exciting causes of insanity in the 19th century. Am J Psychiatry  2020,177(7),576-588","journal-title":"Am J Psychiatry"},{"key":"ref=85","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41398-018-0356-7","volume":"9","author":"Arnau-Soler A.","year":"2019","unstructured":"Arnau-Soler A.; Adams M.J.; Clarke T.K.; MacIntyre D.J.; Milburn K.; Navrady L.; Generation Scotland; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Hayward C, McIntosh A, Thomson PA. A validation of the diathesis-stress model for depression in Generation Scotland. Transl Psychiatry  2019,9(1),25","journal-title":"Transl Psychiatry"},{"key":"ref=86","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1017\/S0954579418001438","volume":"32","author":"Jolicoeur-Martineau A.","year":"2020","unstructured":"Jolicoeur-Martineau A.; Belsky J.; Szekely E.; Widaman K.F.; Pluess M.; Greenwood C.; Wazana A.; Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model. Dev Psychopathol  2020,32(1),73-83","journal-title":"Dev Psychopathol"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/S0006-3223(02)01396-3","volume":"52","author":"Tillfors M.","year":"2002","unstructured":"Tillfors M.; Furmark T.; Marteinsdottir I.; Fredrikson M.; Cerebral blood flow during anticipation of public speaking in social phobia: A PET study. Biol Psychiatry  2002,52(11),1113-1119","journal-title":"Biol Psychiatry"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/mp.2010.120","volume":"16","author":"Luscher B.","year":"2011","unstructured":"Luscher B.; Shen Q.; Sahir N.; The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry  2011,16(4),383-406","journal-title":"Mol Psychiatry"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3389\/fncel.2017.00305","volume":"11","author":"Liu B.","year":"2017","unstructured":"Liu B.; Liu J.; Wang M.; Zhang Y.; Li L.; From serotonin to neuroplasticity: evolvement of theories for major depressive disorder. Front Cell Neurosci  2017,11,305","journal-title":"Front Cell Neurosci"},{"key":"ref=90","doi-asserted-by":"publisher","first-page":"1054887","DOI":"10.3389\/fpsyt.2022.1054887","volume":"13","author":"Guglielmo R.","year":"2022","unstructured":"Guglielmo R.; de Filippis R.; Ouanes S.; Hasler G.; Editorial: The glutamate hypothesis of mood disorders: Neuroplasticity processes, clinical features, treatment perspectives. Front Psychiatry  2022,13,1054887","journal-title":"Front Psychiatry"},{"key":"ref=91","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1146\/annurev-med-053013-062946","volume":"66","author":"Abdallah C.G.","year":"2015","unstructured":"Abdallah C.G.; Sanacora G.; Duman R.S.; Krystal J.H.; Ketamine and rapid-acting antidepressants: A window into a new neurobiology for mood disorder therapeutics. Annu Rev Med  2015,66(1),509-523","journal-title":"Annu Rev Med"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0163-7258(02)00328-5","volume":"97","author":"Konradi C.","year":"2003","unstructured":"Konradi C.; Heckers S.; Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol Ther  2003,97(2),153-179","journal-title":"Pharmacol Ther"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fncel.2020.00051","volume":"14","author":"Belov Kirdajova D.","year":"2020","unstructured":"Belov Kirdajova D.; Kriska J.; Tureckova J.; Anderova M.; Ischemia-triggered glutamate excitotoxicity from the perspective of glial cells. Front Cell Neurosci  2020,14,51","journal-title":"Front Cell Neurosci"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1142\/S0219635216500175","volume":"15","author":"Faghihi F.","year":"2016","unstructured":"Faghihi F.; Moustafa A.A.; Impaired neurogenesis of the dentate gyrus is associated with pattern separation deficits: A computational study. J Integr Neurosci  2016,15(3),277-293","journal-title":"J Integr Neurosci"},{"key":"ref=95","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1002\/jnr.22387","volume":"88","author":"Demars M.","year":"2010","unstructured":"Demars M.; Hu Y.S.; Gadadhar A.; Lazarov O.; Impaired neurogenesis is an early event in the etiology of familial Alzheimer\u2019s disease in transgenic mice. J Neurosci Res  2010,88(10),2103-2117","journal-title":"J Neurosci Res"},{"key":"ref=96","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","volume":"59","author":"Duman R.S.","year":"2006","unstructured":"Duman R.S.; Monteggia L.M.; A neurotrophic model for stress-related mood disorders. Biol Psychiatry  2006,59(12),1116-1127","journal-title":"Biol Psychiatry"},{"key":"ref=97","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1098\/rstb.2011.0357","volume":"367","author":"Duman R.S.","year":"2012","unstructured":"Duman R.S.; Li N.; A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists. Philos Trans R Soc Lond B Biol Sci  2012,367(1601),2475-2484","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref=98","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1001\/archpsyc.1997.01830190015002","volume":"54","author":"Duman R.S.","year":"1997","unstructured":"Duman R.S.; Heninger G.R.; Nestler E.J.; A molecular and cellular theory of depression. Arch Gen Psychiatry  1997,54(7),597-606","journal-title":"Arch Gen Psychiatry"},{"key":"ref=99","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.3892\/etm.2021.10565","volume":"22","author":"R\u0103dulescu I.","year":"2021","unstructured":"R\u0103dulescu I.; Dr\u0103goi A.; Trifu S.; Cristea M.; Neuroplasticity and depression: Rewiring the brain\u2019s networks through pharmacological therapy (Review). Exp Ther Med  2021,22(4),1131","journal-title":"Exp Ther Med"},{"key":"ref=100","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","volume":"6","author":"Bathina S.","year":"2015","unstructured":"Bathina S.; Das U.N.; Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci  2015,6(6),1164-1178","journal-title":"Arch Med Sci"},{"key":"ref=101","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1038\/sj.mp.4002075","volume":"12","author":"Groves J.O.","year":"2007","unstructured":"Groves J.O.; Is it time to reassess the BDNF hypothesis of depression? Mol Psychiatry  2007,12(12),1079-1088","journal-title":"Mol Psychiatry"},{"key":"ref=102","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1176\/ajp.137.5.535","volume":"137","author":"Engel G.L.","year":"1980","unstructured":"Engel G.L.; The clinical application of the biopsychosocial model. Am J Psychiatry  1980,137(5),535-544","journal-title":"Am J Psychiatry"},{"key":"ref=103","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1054\/math.2001.0426","volume":"7","author":"Jones M.","year":"2002","unstructured":"Jones M.; Edwards I.; Gifford L.; Conceptual models for implementing biopsychosocial theory in clinical practice. Man Ther  2002,7(1),2-9","journal-title":"Man Ther"},{"key":"ref=104","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1097\/PHM.0b013e31823d54be","volume":"91","author":"\u00c1lvarez A.S.","year":"2012","unstructured":"\u00c1lvarez A.S.; Pagani M.; Meucci P.; The clinical application of the biopsychosocial model in mental health: A research critique. Am J Phys Med Rehabil  2012,91(13)(Suppl. 1),S173-S180","journal-title":"Am J Phys Med Rehabil"},{"key":"ref=105","doi-asserted-by":"publisher","first-page":"106289","DOI":"10.1016\/j.psyneuen.2023.106289","volume":"154","author":"Juster R.P.","year":"2023","unstructured":"Juster R.P.; Misiak B.; Advancing the allostatic load model: From theory to therapy. Psychoneuroendocrinology  2023,154,106289","journal-title":"Psychoneuroendocrinology"},{"key":"ref=106","doi-asserted-by":"publisher","first-page":"105951","DOI":"10.1016\/j.psyneuen.2022.105951","volume":"146","author":"Bobba-Alves N.","year":"2022","unstructured":"Bobba-Alves N.; Juster R.P.; Picard M.; The energetic cost of allostasis and allostatic load. Psychoneuroendocrinology  2022,146,105951","journal-title":"Psychoneuroendocrinology"},{"key":"ref=107","doi-asserted-by":"publisher","first-page":"105725","DOI":"10.1016\/j.psyneuen.2022.105725","volume":"140","author":"Sandifer P.A.","year":"2022","unstructured":"Sandifer P.A.; Juster R.P.; Seeman T.E.; Lichtveld M.Y.; Singer B.H.; Allostatic load in the context of disasters. Psychoneuroendocrinology  2022,140,105725","journal-title":"Psychoneuroendocrinology"},{"key":"ref=108","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1177\/0963721415581476","volume":"24","author":"Gianaros P.J.","year":"2015","unstructured":"Gianaros P.J.; Wager T.D.; Brain-body pathways linking psychological stress and physical health. Curr Dir Psychol Sci  2015,24(4),313-321","journal-title":"Curr Dir Psychol Sci"},{"key":"ref=109","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1146\/annurev-med-052209-100430","volume":"62","author":"McEwen B.S.","year":"2011","unstructured":"McEwen B.S.; Gianaros P.J.; Stress- and allostasis-induced brain plasticity. Annu Rev Med  2011,62(1),431-445","journal-title":"Annu Rev Med"},{"key":"ref=110","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1037\/a0017773","volume":"117","author":"Ganzel B.L.","year":"2010","unstructured":"Ganzel B.L.; Morris P.A.; Wethington E.; Allostasis and the human brain: Integrating models of stress from the social and life sciences. Psychol Rev  2010,117(1),134-174","journal-title":"Psychol Rev"},{"key":"ref=111","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.physbeh.2011.08.019","volume":"106","author":"Danese A.","year":"2012","unstructured":"Danese A.; McEwen B.S.; Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol Behav  2012,106(1),29-39","journal-title":"Physiol Behav"},{"key":"ref=112","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1037\/0033-2909.98.2.310","volume":"98","author":"Cohen S.","year":"1985","unstructured":"Cohen S.; Wills T.A.; Stress, social support, and the buffering hypothesis. Psychol Bull  1985,98(2),310-357","journal-title":"Psychol Bull"},{"key":"ref=113","doi-asserted-by":"publisher","first-page":"e0189849","DOI":"10.1371\/journal.pone.0189849","volume":"13","author":"Gellert P.","year":"2018","unstructured":"Gellert P.; H\u00e4usler A.; Suhr R.; Gholami M.; Rapp M.; Kuhlmey A.; Nordheim J.; Testing the stress-buffering hypothesis of social support in couples coping with early-stage dementia. PLoS One  2018,13(1),e0189849","journal-title":"PLoS One"},{"key":"ref=114","doi-asserted-by":"publisher","first-page":"2","DOI":"10.31486\/toj.22.0109","volume":"23","author":"Shahid M.","year":"2023","unstructured":"Shahid M.; Physician well-being and the promise of positive psychology. Ochsner J  2023,23(1),2-4","journal-title":"Ochsner J"},{"key":"ref=115","doi-asserted-by":"publisher","first-page":"746151","DOI":"10.3389\/fimmu.2021.746151","volume":"12","author":"Russo S.","year":"2021","unstructured":"Russo S.; Kwiatkowski M.; Govorukhina N.; Bischoff R.; Melgert B.N.; Meta-inflammation and metabolic reprogramming of macrophages in diabetes and obesity: The importance of metabolites. Front Immunol  2021,12,746151","journal-title":"Front Immunol"},{"key":"ref=116","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.mce.2018.05.010","volume":"477","author":"Kumar D.","year":"2018","unstructured":"Kumar D.; Shankar K.; Patel S.; Gupta A.; Varshney S.; Gupta S.; Rajan S.; Srivastava A.; Vishwakarma A.L.; Gaikwad A.N.; Chronic hyperinsulinemia promotes meta-inflammation and extracellular matrix deposition in adipose tissue: Implications of nitric oxide. Mol Cell Endocrinol  2018,477,15-28","journal-title":"Mol Cell Endocrinol"},{"key":"ref=117","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.3389\/fimmu.2017.01960","volume":"8","author":"Fulop T.","year":"2018","unstructured":"Fulop T.; Larbi A.; Dupuis G.; Le Page A.; Frost E.H.; Cohen A.A.; Witkowski J.M.; Franceschi C.; Immunosenescence and inflamm-aging as two sides of the same coin: Friends or foes? Front Immunol  2018,8,1960","journal-title":"Front Immunol"},{"key":"ref=118","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/bfgp\/elab009","volume":"21","author":"Lu R.J.","year":"2022","unstructured":"Lu R.J.; Wang E.K.; Benayoun B.A.; Functional genomics of inflamm-aging and immunosenescence. Brief Funct Genomics  2022,21(1),43-55","journal-title":"Brief Funct Genomics"},{"key":"ref=119","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.3390\/nu14102103","volume":"14","author":"Vetrani C.","year":"2022","unstructured":"Vetrani C.; Di Nisio A.; Paschou S.A.; Barrea L.; Muscogiuri G.; Graziadio C.; Savastano S.; Colao A.; From gut microbiota through low-grade inflammation to obesity: Key players and potential targets. Nutrients On behalf of the obesity programs Of nutrition education research and assessment opera group 2022,14(10),2103","journal-title":"Nutrients"},{"key":"ref=120","doi-asserted-by":"publisher","first-page":"7910","DOI":"10.3390\/ijms24097910","volume":"24","author":"Gusev E.","year":"2023","unstructured":"Gusev E.; Sarapultsev A.; Atherosclerosis and inflammation: Insights from the theory of general pathological processes. Int J Mol Sci  2023,24(9),7910","journal-title":"Int J Mol Sci"},{"key":"ref=121","doi-asserted-by":"publisher","first-page":"251","DOI":"10.2174\/1381612825666190319114641","volume":"25","author":"Gusev E.Y.","year":"2019","unstructured":"Gusev E.Y.; Zotova N.V.; Cellular stress and general pathological processes. Curr Pharm Des  2019,25(3),251-297","journal-title":"Curr Pharm Des"},{"key":"ref=122","doi-asserted-by":"publisher","first-page":"180","DOI":"10.2174\/0113816128285578231218102020","volume":"30","author":"Gusev E.","year":"2024","unstructured":"Gusev E.; Sarapultsev A.; Interplay of G-proteins and serotonin in the neuroimmunoinflammatory model of chronic stress and depression: A narrative review. Curr Pharm Des  2024,30(3),180-214","journal-title":"Curr Pharm Des"},{"key":"ref=123","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s43556-023-00151-1","volume":"4","author":"Sarapultsev A.","year":"2023","unstructured":"Sarapultsev A.; Gusev E.; Komelkova M.; Utepova I.; Luo S.; Hu D.; JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions. Molecular Biomedicine  2023,4(1),40","journal-title":"Molecular Biomedicine"},{"key":"ref=124","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s12640-012-9348-1","volume":"23","author":"Hurley L.L.","year":"2013","unstructured":"Hurley L.L.; Tizabi Y.; Neuroinflammation, neurodegeneration, and depression. Neurotox Res  2013,23(2),131-144","journal-title":"Neurotox Res"},{"key":"ref=125","doi-asserted-by":"publisher","first-page":"77","DOI":"10.31887\/DCNS.2013.15.1\/bbewernick","volume":"15","author":"Bewernick B.H.","year":"2013","unstructured":"Bewernick B.H.; Schlaepfer T.E.; Chronic depression as a model disease for cerebral aging. Dialogues Clin Neurosci  2013,15(1),77-85","journal-title":"Dialogues Clin Neurosci"},{"key":"ref=126","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.pnpbp.2011.02.019","volume":"35","author":"Maes M.","year":"2011","unstructured":"Maes M.; Leonard B.; Fernandez A.; Kubera M.; Nowak G.; Veerhuis R.; Gardner A.; Ruckoanich P.; Geffard M.; Altamura C.; Galecki P.; Berk M.; (Neuro)inflammation and neuroprogression as new pathways and drug targets in depression: From antioxidants to kinase inhibitors. Prog Neuropsychopharmacol Biol Psychiatry  2011,35(3),659-663","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref=127","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.neuroscience.2013.04.060","volume":"246","author":"Felger J.C.","year":"2013","unstructured":"Felger J.C.; Lotrich F.E.; Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications. Neuroscience  2013,246,199-229","journal-title":"Neuroscience"},{"key":"ref=128","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s12974-022-02492-0","volume":"19","author":"Wang H.","year":"2022","unstructured":"Wang H.; He Y.; Sun Z.; Ren S.; Liu M.; Wang G.; Yang J.; Microglia in depression: An overview of microglia in the pathogenesis and treatment of depression. J Neuroinflammation  2022,19(1),132","journal-title":"J Neuroinflammation"},{"key":"ref=129","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s11427-020-1815-6","volume":"64","author":"Jia X.","year":"2021","unstructured":"Jia X.; Gao Z.; Hu H.; Microglia in depression: current perspectives. Sci China Life Sci  2021,64(6),911-925","journal-title":"Sci China Life Sci"},{"key":"ref=130","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3390\/antiox12020470","volume":"12","author":"Correia A.S.","year":"2023","unstructured":"Correia A.S.; Cardoso A.; Vale N.; Oxidative stress in depression: The link with the stress response, neuroinflammation, serotonin, neurogenesis and synaptic plasticity. Antioxidants  2023,12(2),470","journal-title":"Antioxidants"},{"key":"ref=131","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/mp.2010.52","volume":"16","author":"Shelton R.C.","year":"2011","unstructured":"Shelton R.C.; Claiborne J.; Sidoryk-Wegrzynowicz M.; Reddy R.; Aschner M.; Lewis D.A.; Mirnics K.; Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol Psychiatry  2011,16(7),751-762","journal-title":"Mol Psychiatry"},{"key":"ref=132","doi-asserted-by":"publisher","first-page":"104718","DOI":"10.1016\/j.neubiorev.2022.104718","volume":"138","author":"Burtscher J.","year":"2022","unstructured":"Burtscher J.; Niedermeier M.; H\u00fcfner K.; van den Burg E.; Kopp M.; Stoop R.; Burtscher M.; Gatterer H.; Millet G.P.; The interplay of hypoxic and mental stress: Implications for anxiety and depressive disorders. Neurosci Biobehav Rev  2022,138,104718","journal-title":"Neurosci Biobehav Rev"},{"key":"ref=133","doi-asserted-by":"publisher","first-page":"105926","DOI":"10.1016\/j.nbd.2022.105926","volume":"175","author":"Medina-Rodriguez E.M.","year":"2022","unstructured":"Medina-Rodriguez E.M.; Beurel E.; Blood brain barrier and inflammation in depression. Neurobiol Dis  2022,175,105926","journal-title":"Neurobiol Dis"},{"key":"ref=134","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/s41398-020-00920-4","volume":"10","author":"van Eeden W.A.","year":"2020","unstructured":"van Eeden W.A.; van Hemert A.M.; Carlier I.V.E.; Penninx B.W.J.H.; Lamers F.; Fried E.I.; Schoevers R.; Giltay E.J.; Basal and LPS-stimulated inflammatory markers and the course of individual symptoms of depression. Transl Psychiatry  2020,10(1),235","journal-title":"Transl Psychiatry"},{"key":"ref=135","doi-asserted-by":"publisher","first-page":"927","DOI":"10.3390\/nu13030927","volume":"13","author":"Trzeciak P.","year":"2021","unstructured":"Trzeciak P.; Herbet M.; Role of the intestinal microbiome, intestinal barrier and psychobiotics in depression. Nutrients  2021,13(3),927","journal-title":"Nutrients"},{"key":"ref=136","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.3389\/fimmu.2018.02031","volume":"9","author":"Fioranelli M.","year":"2018","unstructured":"Fioranelli M.; Bottaccioli A.G.; Bottaccioli F.; Bianchi M.; Rovesti M.; Roccia M.G.; Stress and inflammation in coronary artery disease: A review psychoneuroendocrineimmunology-based. Front Immunol  2018,9,2031","journal-title":"Front Immunol"},{"key":"ref=137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/neu.2016.69","volume":"30","author":"Leonard B.E.","year":"2018","unstructured":"Leonard B.E.; Inflammation and depression: A causal or coincidental link to the pathophysiology? Acta Neuropsychiatr  2018,30(1),1-16","journal-title":"Acta Neuropsychiatr"},{"key":"ref=138","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fnhum.2017.00316","volume":"11","author":"Liu Y.Z.","year":"2017","unstructured":"Liu Y.Z.; Wang Y.X.; Jiang C.L.; Inflammation: The common pathway of stress-related diseases. Front Hum Neurosci  2017,11,316","journal-title":"Front Hum Neurosci"},{"key":"ref=139","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1038\/s41467-020-15655-5","volume":"11","author":"Kim J.","year":"2020","unstructured":"Kim J.; Yoon S.; Lee S.; Hong H.; Ha E.; Joo Y.; Lee E.H.; Lyoo I.K.; A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms. Nat Commun  2020,11(1),1898","journal-title":"Nat Commun"},{"key":"ref=140","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jad.2020.10.004","volume":"279","author":"Gialluisi A.","year":"2021","unstructured":"Gialluisi A.; Costanzo S.; Castelnuovo A.D.; Bonaccio M.; Bracone F.; Magnacca S.; De Curtis A.; Cerletti C.; Donati M.B.; de Gaetano G.; Iacoviello L.; Combined influence of depression severity and low-grade inflammation on incident hospitalization and mortality risk in Italian adults. J Affect Disord  2021,279,173-182","journal-title":"J Affect Disord"},{"key":"ref=141","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.brainres.2019.04.024","volume":"1718","author":"Wang H.","year":"2019","unstructured":"Wang H.; Wang Y.; Wang R.; Li Y.; Wang P.; Li J.; Du J.; Hypertrophic olivary degeneration: A comprehensive review focusing on etiology. Brain Res  2019,1718,53-63","journal-title":"Brain Res"},{"key":"ref=142","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.neurobiolaging.2023.05.004","volume":"129","author":"Williams M.E.","year":"2023","unstructured":"Williams M.E.; Elman J.A.; Bell T.R.; Dale A.M.; Eyler L.T.; Fennema-Notestine C.; Franz C.E.; Gillespie N.A.; Hagler D.J.; Lyons M.J.; McEvoy L.K.; Neale M.C.; Panizzon M.S.; Reynolds C.A.; Sanderson-Cimino M.; Kremen W.S.; Higher cortical thickness\/volume in Alzheimer\u2019s-related regions: protective factor or risk factor? Neurobiol Aging  2023,129,185-194","journal-title":"Neurobiol Aging"},{"key":"ref=143","doi-asserted-by":"publisher","first-page":"4053","DOI":"10.1038\/s41467-023-39861-z","volume":"14","author":"Han S.","year":"2023","unstructured":"Han S.; Cui Q.; Zheng R.; Li S.; Zhou B.; Fang K.; Sheng W.; Wen B.; Liu L.; Wei Y.; Chen H.; Chen Y.; Cheng J.; Zhang Y.; Parsing altered gray matter morphology of depression using a framework integrating the normative model and non-negative matrix factorization. Nat Commun  2023,14(1),4053","journal-title":"Nat Commun"},{"key":"ref=144","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jad.2023.02.145","volume":"330","author":"Kang W.","year":"2023","unstructured":"Kang W.; Kang Y.; Kim A.; Kim H.; Han K.M.; Ham B.J.; Gray and white matter abnormalities in major depressive disorder patients and its associations with childhood adversity. J Affect Disord  2023,330,16-23","journal-title":"J Affect Disord"},{"key":"ref=145","doi-asserted-by":"publisher","first-page":"kkad017","DOI":"10.1093\/psyrad\/kkad017","volume":"3","author":"Qiu X.","year":"2023","unstructured":"Qiu X.; Li J.; Pan F.; Yang Y.; Zhou W.; Chen J.; Aberrant single-subject morphological brain networks in first-episode, treatment-naive adolescents with major depressive disorder. Psychoradiology  2023,3,kkad017","journal-title":"Psychoradiology"},{"key":"ref=146","doi-asserted-by":"publisher","first-page":"114414","DOI":"10.1016\/j.bbr.2023.114414","volume":"447","author":"Yang W.","year":"2023","unstructured":"Yang W.; Jiang Y.; Ma L.; Xiao M.; Liu M.; Ren Z.; Zhang Y.; Hu L.; Cortical and subcortical morphological alterations in postpartum depression. Behav Brain Res  2023,447,114414","journal-title":"Behav Brain Res"},{"key":"ref=147","doi-asserted-by":"publisher","first-page":"1201256","DOI":"10.3389\/fpsyt.2023.1201256","volume":"14","author":"Shao H.","year":"2023","unstructured":"Shao H.; Li N.; Chen M.; Zhang J.; Chen H.; Zhao M.; Yang J.; Xia J.; A voxel-based morphometry investigation of brain structure variations in late-life depression with insomnia. Front Psychiatry  2023,14,1201256","journal-title":"Front Psychiatry"},{"key":"ref=148","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s11682-023-00797-z","volume":"17","author":"Liang J.","year":"2023","unstructured":"Liang J.; Yu Q.; Liu Y.; Qiu Y.; Tang R.; Yan L.; Zhou P.; Gray matter abnormalities in patients with major depressive disorder and social anxiety disorder: A voxel-based meta-analysis. Brain Imaging Behav  2023,17(6),749-763","journal-title":"Brain Imaging Behav"},{"key":"ref=149","doi-asserted-by":"publisher","first-page":"AN20090026","DOI":"10.1042\/AN20090026","volume":"1","author":"Bearden C.E.","year":"2009","unstructured":"Bearden C.E.; Thompson P.M.; Avedissian C.; Klunder A.D.; Nicoletti M.; Dierschke N.; Brambilla P.; Soares J.C.; Altered hippocampal morphology in unmedicated patients with major depressive illness. ASN Neuro  2009,1(4),AN20090026","journal-title":"ASN Neuro"},{"key":"ref=150","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jad.2014.09.048","volume":"172","author":"Travis S.","year":"2015","unstructured":"Travis S.; Coupland N.J.; Silversone P.H.; Huang Y.; Fujiwara E.; Carter R.; Seres P.; Malykhin N.V.; Dentate gyrus volume and memory performance in major depressive disorder. J Affect Disord  2015,172,159-164","journal-title":"J Affect Disord"},{"key":"ref=151","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.eurpsy.2019.01.016","volume":"57","author":"Han K.M.","year":"2019","unstructured":"Han K.M.; Kim A.; Kang W.; Kang Y.; Kang J.; Won E.; Tae W.S.; Ham B.J.; Hippocampal subfield volumes in major depressive disorder and bipolar disorder. Eur Psychiatry  2019,57,70-77","journal-title":"Eur Psychiatry"},{"key":"ref=152","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1186\/s12888-023-05146-4","volume":"23","author":"Chen Y.","year":"2023","unstructured":"Chen Y.; Jia L.; Gao W.; Wu C.; Mu Q.; Fang Z.; Hu S.; Huang M.; Zhang P.; Lu S.; Alterations of brainstem volume in patients with first-episode and recurrent major depressive disorder. BMC Psychiatry  2023,23(1),687","journal-title":"BMC Psychiatry"},{"key":"ref=153","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.bbi.2019.05.017","volume":"80","author":"Frank P.","year":"2019","unstructured":"Frank P.; Kaushal A.; Poole L.; Lawes S.; Chalder T.; Cadar D.; Systemic low-grade inflammation and subsequent depressive symptoms: Is there a mediating role of physical activity? Brain Behav Immun  2019,80,688-696","journal-title":"Brain Behav Immun"},{"key":"ref=154","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1159\/000515594","volume":"28","author":"Bauer M.E.","year":"2021","unstructured":"Bauer M.E.; Teixeira A.L.; Neuroinflammation in mood disorders: Role of regulatory immune cells. Neuroimmunomodulation  2021,28(3),99-107","journal-title":"Neuroimmunomodulation"},{"key":"ref=155","doi-asserted-by":"publisher","first-page":"883927","DOI":"10.3389\/fneur.2022.883927","volume":"13","author":"Gar\u00e9s-Caballer M.","year":"2022","unstructured":"Gar\u00e9s-Caballer M.; S\u00e1nchez-Ort\u00ed J.V.; Correa-Ghisays P.; Balanz\u00e1-Mart\u00ednez V.; Selva-Vera G.; Vila-Franc\u00e9s J.; Magdalena-Benedito R.; San-Martin C.; Victor V.M.; Escribano-Lopez I.; Hernandez-Mijares A.; Vivas-Lalinde J.; Vieta E.; Leza J.C.; Tabar\u00e9s-Seisdedos R.; Immune\u2013inflammatory biomarkers predict cognition and social functioning in patients with type 2 diabetes mellitus, major depressive disorder, bipolar disorder, and schizophrenia: A 1-year follow-up study. Front Neurol  2022,13,883927","journal-title":"Front Neurol"},{"key":"ref=156","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1136\/bmj.321.7255.199","volume":"321","author":"Danesh J.","year":"2000","unstructured":"Danesh J.; Whincup P.; Walker M.; Lennon L.; Thomson A.; Appleby P.; Gallimore J.R.; Pepys M.B.; Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. BMJ  2000,321(7255),199-204","journal-title":"BMJ"},{"key":"ref=157","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1159\/000364934","volume":"40","author":"Guarner V.","year":"2015","unstructured":"Guarner V.; Rubio-Ruiz M.E.; Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease. Interdiscip Top Gerontol Geriatr  2015,40,99-106","journal-title":"Interdiscip Top Gerontol Geriatr"},{"key":"ref=158","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2147\/CIA.S285000","volume":"16","author":"Wang J.","year":"2021","unstructured":"Wang J.; Zhou D.; Dai Z.; Li X.; Association between systemic immune-inflammation index and diabetic depression. Clin Interv Aging  2021,16,97-105","journal-title":"Clin Interv Aging"},{"key":"ref=159","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1089\/dia.2006.8.7","volume":"8","author":"Duncan B.B.","year":"2006","unstructured":"Duncan B.B.; Schmidt M.I.; The epidemiology of low- grade chronic systemic inflammation and type 2 diabetes. Diabetes Technol Ther  2006,8(1),7-17","journal-title":"Diabetes Technol Ther"},{"key":"ref=160","doi-asserted-by":"publisher","first-page":"5603","DOI":"10.3390\/ijms22115603","volume":"22","author":"Litwiniuk A.","year":"2021","unstructured":"Litwiniuk A.; Bik W.; Kalisz M.; Baranowska-Bik A.; Inflammasome NLRP3 potentially links obesity-associated low-grade systemic inflammation and insulin resistance with alzheimer\u2019s disease. Int J Mol Sci  2021,22(11),5603","journal-title":"Int J Mol Sci"},{"key":"ref=161","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.3390\/brainsci12091237","volume":"12","author":"Kosyreva A.","year":"2022","unstructured":"Kosyreva A.; Sentyabreva A.; Tsvetkov I.; Makarova O.; Alzheimer\u2019s disease and inflammaging. Brain Sci  2022,12(9),1237","journal-title":"Brain Sci"},{"key":"ref=162","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.brainresbull.2012.08.003","volume":"89","author":"Misiak B.","year":"2012","unstructured":"Misiak B.; Leszek J.; Kiejna A.; Metabolic syndrome, mild cognitive impairment and Alzheimer\u2019s disease-the emerging role of systemic low-grade inflammation and adiposity. Brain Res Bull  2012,89(3-4),144-149","journal-title":"Brain Res Bull"},{"key":"ref=163","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S2215-0366(18)30255-4","volume":"6","author":"Nerurkar L.","year":"2019","unstructured":"Nerurkar L.; Siebert S.; McInnes I.B.; Cavanagh J.; Rheumatoid arthritis and depression: An inflammatory perspective. Lancet Psychiatry  2019,6(2),164-173","journal-title":"Lancet Psychiatry"},{"key":"ref=164","doi-asserted-by":"publisher","first-page":"612104","DOI":"10.3389\/fimmu.2020.612104","volume":"11","author":"S\u00fc\u00df P.","year":"2020","unstructured":"S\u00fc\u00df P.; Rothe T.; Hoffmann A.; Schlachetzki J.C.M.; Winkler J.; The joint-brain axis: Insights from rheumatoid arthritis on the crosstalk between chronic peripheral inflammation and the brain. Front Immunol  2020,11,612104","journal-title":"Front Immunol"},{"key":"ref=165","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/ar3024","volume":"12","author":"Hassett A.L.","year":"2010","unstructured":"Hassett A.L.; Clauw D.J.; The role of stress in rheumatic diseases. Arthritis Res Ther  2010,12(3),123","journal-title":"Arthritis Res Ther"},{"key":"ref=166","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00406-014-0502-z","volume":"264","author":"Fond G.","year":"2014","unstructured":"Fond G.; Loundou A.; Hamdani N.; Boukouaci W.; Dargel A.; Oliveira J.; Roger M.; Tamouza R.; Leboyer M.; Boyer L.; Anxiety and depression comorbidities in irritable bowel syndrome (IBS): A systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci  2014,264(8),651-660","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref=167","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1017\/S0033291716001987","volume":"46","author":"Sibelli A.","year":"2016","unstructured":"Sibelli A.; Chalder T.; Everitt H.; Workman P.; Windgassen S.; Moss-Morris R.; A systematic review with meta-analysis of the role of anxiety and depression in irritable bowel syndrome onset. Psychol Med  2016,46(15),3065-3080","journal-title":"Psychol Med"},{"key":"ref=168","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.biopsych.2015.01.005","volume":"78","author":"Michopoulos V.","year":"2015","unstructured":"Michopoulos V.; Norrholm S.D.; Jovanovic T.; Diagnostic biomarkers for posttraumatic stress disorder: Promising horizons from translational neuroscience research. Biol Psychiatry  2015,78(5),344-353","journal-title":"Biol Psychiatry"},{"key":"ref=169","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/pcn.12820","volume":"73","author":"Hori H.","year":"2019","unstructured":"Hori H.; Kim Y.; Inflammation and post-traumatic stress disorder. Psychiatry Clin Neurosci  2019,73(4),143-153","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref=170","doi-asserted-by":"publisher","first-page":"524","DOI":"10.2174\/1570159X21666230807152051","volume":"22","author":"Patas K.","year":"2024","unstructured":"Patas K.; Baker D.G.; Chrousos G.P.; Agorastos A.; Inflammation in posttraumatic stress disorder: Dysregulation or recalibration? Curr Neuropharmacol  2024,22(4),524-542","journal-title":"Curr Neuropharmacol"},{"key":"ref=171","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2147\/JIR.S155903","volume":"11","author":"Speer K.","year":"2018","unstructured":"Speer K.; Upton D.; Semple S.; McKune A.; Systemic low-grade inflammation in post-traumatic stress disorder: A systematic review. J Inflamm Res  2018,11,111-121","journal-title":"J Inflamm Res"},{"key":"ref=172","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1016\/j.jacc.2009.09.009","volume":"54","author":"Libby P.","year":"2009","unstructured":"Libby P.; Ridker P.M.; Hansson G.K.; Inflammation in Atherosclerosis. J Am Coll Cardiol  2009,54(23),2129-2138","journal-title":"J Am Coll Cardiol"},{"key":"ref=173","doi-asserted-by":"publisher","first-page":"108336","DOI":"10.1016\/j.jdiacomp.2022.108336","volume":"36","author":"Rizvi A.A.","year":"2022","unstructured":"Rizvi A.A.; Kathuria A.; Al Mahmeed W.; Al-Rasadi K.; Al-Alawi K.; Banach M.; Banerjee Y.; Ceriello A.; Cesur M.; Cosentino F.; Galia M.; Goh S.Y.; Janez A.; Kalra S.; Kempler P.; Lessan N.; Lotufo P.; Papanas N.; Santos R.D.; Stoian A.P.; Toth P.P.; Viswanathan V.; Rizzo M.; Post-COVID syndrome, inflammation, and diabetes. J Diabetes Complications  2022,36(11),108336","journal-title":"J Diabetes Complications"},{"key":"ref=174","doi-asserted-by":"publisher","first-page":"101571","DOI":"10.1016\/j.bbrep.2023.101571","volume":"36","author":"Mehdi S.","year":"2023","unstructured":"Mehdi S.; Wani S.U.D.; Krishna K.L.; Kinattingal N.; Roohi T.F.; A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation. Biochem Biophys Rep  2023,36,101571","journal-title":"Biochem Biophys Rep"},{"key":"ref=175","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.bbi.2020.12.020","volume":"93","author":"Sen Z.D.","year":"2021","unstructured":"Sen Z.D.; Danyeli L.V.; Woelfer M.; Lamers F.; Wagner G.; Sobanski T.; Walter M.; Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions. Brain Behav Immun  2021,93,335-352","journal-title":"Brain Behav Immun"},{"key":"ref=176","doi-asserted-by":"publisher","first-page":"7393","DOI":"10.1038\/s41380-021-01188-w","volume":"26","author":"Milaneschi Y.","year":"2021","unstructured":"Milaneschi Y.; Kappelmann N.; Ye Z.; Lamers F.; Moser S.; Jones P.B.; Burgess S.; Penninx B.W.J.H.; Khandaker G.M.; Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts. Mol Psychiatry  2021,26(12),7393-7402","journal-title":"Mol Psychiatry"},{"key":"ref=177","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/s41398-023-02518-y","volume":"13","author":"Liu L.","year":"2023","unstructured":"Liu L.; Cheng S.; Qi X.; Meng P.; Yang X.; Pan C.; Chen Y.; Zhang H.; Zhang Z.; Zhang J.; Li C.; Wen Y.; Jia Y.; Cheng B.; Zhang F.; Mitochondria-wide association study observed significant interactions of mitochondrial respiratory and the inflammatory in the development of anxiety and depression. Transl Psychiatry  2023,13(1),216","journal-title":"Transl Psychiatry"},{"key":"ref=178","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s00406-018-0908-0","volume":"269","author":"Fond G.","year":"2019","unstructured":"Fond G.; Godin O.; Boyer L.; Berna F.; Andrianarisoa M.; Coulon N.; Brunel L.; Bulzacka E.; Aouizerate B.; Capdevielle D.; Chereau I.; D\u2019Amato T.; Dubertret C.; Dubreucq J.; Faget C.; Leignier S.; Lan\u00e7on C.; Mallet J.; Misdrahi D.; Passerieux C.; Rey R.; Schandrin A.; Urbach M.; Vidailhet P.; Llorca P.M.; Sch\u00fcrhoff F.; Leboyer M.; Chronic low-grade peripheral inflammation is associated with ultra resistant schizophrenia. Results from the FACE-SZ cohort. Eur Arch Psychiatry Clin Neurosci  2019,269(8),985-992","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref=179","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s00406-017-0847-1","volume":"268","author":"Fond G.","year":"2018","unstructured":"Fond G.; Resseguier N.; Sch\u00fcrhoff F.; Godin O.; Andrianarisoa M.; Brunel L.; Bulzacka E.; Aouizerate B.; Berna F.; Capdevielle D.; Chereau I.; D\u2019Amato T.; Dubertret C.; Dubreucq J.; Faget C.; Gabayet F.; Lan\u00e7on C.; Llorca P.M.; Mallet J.; Misdrahi D.; Passerieux C.; Rey R.; Schandrin A.; Urbach M.; Vidailhet P.; Boyer L.; Leboyer M.; Relationships between low-grade peripheral inflammation and psychotropic drugs in schizophrenia: results from the national FACE-SZ cohort. Eur Arch Psychiatry Clin Neurosci  2018,268(6),541-553","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref=180","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00406-017-0771-4","volume":"267","author":"Fond G.","year":"2017","unstructured":"Fond G.; Berna F.; Andrianarisoa M.; Godin O.; Leboyer M.; Brunel L.; Aouizerate B.; Capdevielle D.; Chereau I.; D\u2019Amato T.; Denizot H.; Dubertret C.; Dubreucq J.; Faget C.; Gabayet F.; Llorca P.M.; Mallet J.; Misdrahi D.; Passerieux C.; Richieri R.; Rey R.; Schandrin A.; Urbach M.; Vidailhet P.; Boyer L.; Sch\u00fcrhoff F.; Chronic low-grade peripheral inflammation is associated with severe nicotine dependence in schizophrenia: results from the national multicentric FACE-SZ cohort. Eur Arch Psychiatry Clin Neurosci  2017,267(5),465-472","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref=181","doi-asserted-by":"publisher","first-page":"16031","DOI":"10.3390\/ijms232416031","volume":"23","author":"Naumovs V.","year":"2022","unstructured":"Naumovs V.; Groma V.; Mednieks J.; From low-grade inflammation in osteoarthritis to neuropsychiatric sequelae: A narrative review. Int J Mol Sci  2022,23(24),16031","journal-title":"Int J Mol Sci"},{"key":"ref=182","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.bbi.2022.12.012","volume":"108","author":"Goldschen L.","year":"2023","unstructured":"Goldschen L.; Ellrodt J.; Amonoo H.L.; Feldman C.H.; Case S.M.; Koenen K.C.; Kubzansky L.D.; Costenbader K.H.; The link between post-traumatic stress disorder and systemic lupus erythematosus. Brain Behav Immun  2023,108,292-301","journal-title":"Brain Behav Immun"},{"key":"ref=183","doi-asserted-by":"publisher","first-page":"495","DOI":"10.4149\/gpb_2023022","volume":"42","author":"Komelkova M.","year":"2023","unstructured":"Komelkova M.; Yushkov B.; Fedorov S.; Ibragimov R.; Platkovskiy P.; Hu D.; Luo S.; Sarapultsev A.; Early-life maternal deprivation in rats increases sensitivity to the subsequent stressors: A pilot study. Gen Physiol Biophys  2023,42(6),495-506","journal-title":"Gen Physiol Biophys"}],"container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0109298673320710240920055041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/234653\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0109298673320710240920055041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:34:44Z","timestamp":1785753284000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/234653\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":183,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0109298673320710240920055041","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2024-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}