{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T14:04:58Z","timestamp":1794405898227,"version":"4.9.0"},"reference-count":47,"publisher":"Bentham Science Publishers Ltd.","issue":"29","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":69,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>An excessive inflammatory response plays a central role in the\npathogenesis of ulcerative colitis (UC), but the specific cytokines involved remain unclear.\nThis study aimed to identify inflammatory factors associated with UC and explore the possible\nmechanisms of the identified targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Protein quantitative trait loci (pQTLs) and expression quantitative trait loci (eQTLs)\nfor inflammatory cytokines were obtained from a genome-wide pQTL study and the eQTL\nconsortium, respectively. Summary data for UC from the exploration and validation cohorts\nwere derived from a genome-wide association study and the Finngen cohort. MR and colocalization\nanalyses were conducted to identify causal associations between inflammatory cytokines\nand UC. Bioinformatics analyses were employed to explore the involved biological\nprocesses of candidate targets. Immunohistochemistry was used to validate the expression of\nthese candidate targets in colon tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among all inflammatory cytokines, a significant causal association was identified\nbetween C-X-C motif chemokine ligand 5 (CXCL5) and UC. Using eQTL data, a significant\ngenetic association was established between the mRNA expression of CXCL5 and its receptor,\nC-X-C motif chemokine receptor 2 (CXCR2), with UC. Colocalization analysis further\nsupported these identified links. Differential expression analysis confirmed the dysregulation\nof the CXCL5\/CXCR2 axis in UC patients. Enrichment and immune infiltration analysis indicated\nthat the CXCL5\/CXCR2 axis was involved in neutrophil chemotaxis and immune activation\nin UC. Moreover, CXCL5 expression was found to correlate with neutrophil extracellular\ntrap (NET) formation in UC. Immunohistochemistry further confirmed the dysregulation\nof the CXCL5\/CXCR2 axis in colon tissues of UC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The CXCL5\/CXCR2 axis has been implicated to play a significant role within a\nbroader inflammatory network that includes Interleukin (IL)-17, NF-\u03baB, and Tumor Necrosis\nFactor (TNF) signaling pathways. Additionally, this axis interacts with macrophages and T\ncells, further contributing to the complexity of inflammatory responses in UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is a significant association between CXCL5\/CXCR2 and UC under the\nMR assumption, which is potentially linked with colonic chemotaxis and activation of neutrophils.\nThese findings highlight the potential of CXCL5\/CXCR2 as a therapeutic target for\nUC. However, future functional studies are needed to validate these findings and explore the\nexact mechanisms by which CXCL5\/CXCR2 influences immune cell crosstalk in UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0109298673381624251020065846","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:00:30Z","timestamp":1769410830000},"page":"6221-6237","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CXCL5\/CXCR2 Axis Related to Neutrophilic Inflammation in Ulcerative Colitis: A Comprehensive Analysis Integrating eQTL, pQTL, and Transcriptome Data"],"prefix":"10.2174","volume":"33","author":[{"given":"Yiyi","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichuan","family":"Xv","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enjia","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoxia","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianling","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1001\/jama.2020.11583","volume":"324","author":"Glick L.R.","year":"2020","unstructured":"Glick L.R.; Cifu A.S.; Feld L.; Ulcerative colitis in adults. 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