{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:17:05Z","timestamp":1783412225248,"version":"3.54.6"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>On August 8, 2025, Arvinas and Pfizer announced that the FDA had accepted\nthe NDA for vepdegestrant (ARV-471, PF-07850327) for the treatment of patients with\nestrogen receptor-positive (ER+)\/human epidermal growth factor receptor 2-negative\n(HER2-) and ESR1-mutated advanced or metastatic breast cancer who have previously\nreceived endocrine-based therapy. The FDA has assigned a Prescription Drug User Fee\nAct (PDUFA) action date of June 5, 2026. Vepdegestrant, a first-in-class oral PROTAC\n\u00ae estrogen receptor (ER) degrader, is a heterobifunctional molecule. It consists of\nan ER-binding moiety derived from lasofoxifene, a cereblon (CRBN)-targeting ligand\nbased on lenalidomide, and a rigid N-containing heterocycle linker. This structure enables\nselective recruitment of the E3 ubiquitin ligase CRBN to ER, driving ubiquitination\nand proteasomal degradation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0109298673420824251129222720","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:49:37Z","timestamp":1783410577000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Breaking New Ground in Oncology: FDA Acceptance of Vepdegestrant NDA Marks a Milestone for PROTAC Therapies in Breast Cancer"],"prefix":"10.2174","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-509X","authenticated-orcid":true,"given":"Jinwei","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Biology, Research Center of Chemical Kinomics, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai, 200032, China"},{"name":"Faculty of Health and Life Sciences, Medical School, Institute of Biomedical and Clinical Sciences, University of Exeter Hatherly Laboratories, Streatham Campus, Exeter, EX4 4PS, U"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0109298673420824251129222720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/255821\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0109298673420824251129222720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:49:48Z","timestamp":1783410588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/255821\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0109298673420824251129222720","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2025-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}