{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:59:30Z","timestamp":1790315970830,"version":"4.1.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CMC"],"published-print":{"date-parts":[[2026,9,23]]},"abstract":"\n Background:<\/jats:title>\n In the US population, the association and predictive performance of obesity indices -- Body Mass Index (BMI), Body Shape Index (ABSI), Body Roundness Index (BRI), Waist Circumference (WC), and Waist-to-Height Ratio (WHtR) with mortality outcomes Cardiovascular Mortality (CVM) and All-Cause Mortality (ACM)) in prediabetes and diabetes (DM) populations have not been systematically evaluated.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Utilizing NHANES data (prediabetes: n = 10,988, DM: n = 5,868), we evaluated these associations and predictive ability using Kaplan-Meier curves, multivariable Cox proportional hazards models, Restricted Cubic Splines (RCS), and time-dependent ROC analysis, and performed subgroup analyses to assess heterogeneity.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n BMI\/BRI\/WC\/WHtR generally displayed patterns consistent with the \u201cobesity paradox\u201d, while ABSI did not clearly conform to this paradox. In two-piecewise Cox models, ABSI was not associated with CVM but demonstrated a significant, non-paradox association with ACM in DM at higher ABSI levels. RCS revealed nonlinear associations for BMI\/BRI\/WC\/WHtR, while ABSI showed a nonlinear association only with ACM (inflection point: prediabetes = 0.82, DM = 0.77). In unadjusted ROC analyses, ABSI generally showed higher discriminative ability for mortality outcomes; however, after full adjustment, AUC values became similar across indicators. Subgroup analyses further indicated that the predictive performance of these indicators varied across different smoking statuses, race, and sex.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n The \u201cobesity paradox\u201d observed in BMI\/BRI\/WC\/WHtR likely reflects their inability to distinguish fat from muscle. ABSI, which primarily captures central adiposity, did not clearly conform to this paradox; however, its incremental predictive value diminished after adjustment, suggesting substantial overlap with conventional risk factors.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Unlike BMI, BRI, WC, and WHtR, ABSI did not display a clear \u201cobesity paradox\u201d pattern and showed higher unadjusted discrimination for mortality outcomes, although this advantage was attenuated after full adjustment, suggesting it may provide complementary risk information.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/0109298673481562260914095259","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:22:02Z","timestamp":1790313722000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparative Evaluation of Five Obesity Indices for Cardiovascular and All-Cause Mortality Prediction in Prediabetes and Diabetes Population: A Prospective Cohort"],"prefix":"10.2174","volume":"33","author":[{"given":"Dexiang","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, China"},{"name":"Angiopathy Institute of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, China"},{"name":"Angiopathy Institute of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, China"},{"name":"Angiopathy Institute of Central South University, Changsha, China"},{"name":"Department of Cardiovascular Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Xicheng District, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, China"},{"name":"Angiopathy Institute of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, China"},{"name":"Angiopathy Institute of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0109298673481562260914095259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/258657\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0109298673481562260914095259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:22:37Z","timestamp":1790313757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/258657\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0109298673481562260914095259","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,23]]}}}