{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:50:06Z","timestamp":1791435006020,"version":"4.3.3"},"reference-count":43,"publisher":"Bentham Science Publishers Ltd.","issue":"27","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this study is to elucidate the contribution of circFGFR2\nin Prostate Cancer (PC) cells and to identify the associated molecular regulatory\nmechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study evaluated circFGFR2 levels in PC cell lines and tissues by qRTPCR.\nFurthermore, the impact of circFGFR2 knockdown on the invasion, migration, proliferation,\nand viability of PC cells was explored using CCK-8, colony formation, Transwell,\nand wound-healing assays. Moreover, bioinformatics analysis and luciferase reporter\nassays were used to analyze the binding interactions between circFGFR2,\nmiR-221-5p, and SMUG1. In vitro functional assays further confirmed that circFGFR2\nmodulates the proliferation and migration of the PC cells via the miR-221-5p\/SMUG1\nsignaling pathway. Lastly, a xenograft mouse model was established to assess the impact\nof circFGFR2 knockdown on in vivo tumor growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The data showed that circFGFR2 was significantly upregulated in PC tissues.\nFurthermore, in vitro and in vivo analyses revealed that circFGFR2 silencing markedly\nreduced the invasion, proliferation, migration, and colony formation of PC cells. Mechanistic\nstudies demonstrated that circFGFR2 functions as a competitive endogenous\nRNA (ceRNA) to sequester miR-221-5p, which subsequently downregulates SMUG1 expression.\nRescue experiments confirmed that circFGFR2 modulates PC cell migration\nand proliferation via the miR-221-5p\/SMUG1 pathway. These data suggest that circFGFR2\nfunctions as a tumor-promoting circRNA by sponging miR-221-5p, thereby\nderepressing SMUG1. Therefore, circFGFR2 should be evaluated as a clinical biomarker\nfor risk stratification and prognosis. Moreover, targeting circFGFR2 or restoring the\nmiR-221-5p\/SMUG1 balance are effective strategies for inhibiting PC cells\u2019 growth and\ndissemination, extending the circRNA-based framework for precision therapeutic intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>These data identify circFGFR2 as a tumor-promoting circRNA that acts as\na sponge for miR-221-5p, thereby derepressing SMUG1. Moreover, targeting circFGFR2\nor restoring the miR-221-5p\/SMUG1 balance represents a tractable axis to curb\nPCa, and are effective strategy for inhibiting PC cells\u2019 growth and dissemination, offering\nan effective strategy that extends the circRNA-based framework for precision therapeutic\nintervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study indicates that circFGFR2 influences PC cell proliferation and\nmigration via the miR-221-5p\/SMUG1 signaling axis. Therefore, circFGFR2 may serve\nas a potential therapeutic target and a unique molecular biomarker for PC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0109298673485791260521105435","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:58:36Z","timestamp":1783324716000},"page":"5855-5873","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Knockdown of CircFGFR2 Inhibits Prostate Cancer Cell Metastasis and Proliferation by Targeting the miR-221-5p\/SMUG1 Pathway"],"prefix":"10.2174","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2131-1053","authenticated-orcid":true,"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology, Shenzhen Longhua District Central Hospital, The Affiliated Longhua Hospital ofShenzhen University, Shenzhen, 518110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-9170","authenticated-orcid":true,"given":"Jiqing","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Urology, Shenzhen Longhua District Central Hospital, The Affiliated Longhua Hospital ofShenzhen University, Shenzhen, 518110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2553-3420","authenticated-orcid":true,"given":"Ling","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Urology, Shenzhen Longhua District Central Hospital, The Affiliated Longhua Hospital ofShenzhen University, Shenzhen, 518110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2178-5666","authenticated-orcid":true,"given":"Shi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, ShenzhenLonghua District Central Hospital, The Affiliated Longhua Hospital of Shenzhen University, Shenzhen,518110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9145-0901","authenticated-orcid":true,"given":"Naixiong","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Urology, Shenzhen Longhua District Central Hospital, The Affiliated Longhua Hospital ofShenzhen University, Shenzhen, 518110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3322\/caac.70028","volume":"75","author":"Kratzer T.B.","year":"2025","unstructured":"Kratzer T.B.; Mazzitelli N.; Star J.; Dahut W.L.; Jemal A.; Siegel R.L.; Prostate cancer statistics, 2025. 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