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Panax notoginseng saponins\n(PNS) are considered to be effective herb compounds for preventing ISR.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study aimed to elucidate the targets and mechanisms of PNS in ISR prevention using network\npharmacology approaches and experimental verification.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Relevant targets of PNS active compounds were collected from the HERB database and PharmMapper.\nThe ISR-related targets were obtained from the GeneCards database and the Comparative Toxicogenomics\nDatabase. The GO and KEGG enrichment analysis was performed using R software. The String\ndatabase and Cytoscape software were employed to build the PPI and compounds-targets-pathways-disease\nnetworks. Finally, Molecular docking performed by Autodock Vina and cellular experiments were used to validate\nnetwork pharmacology results.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>There were 40 common targets between PNS targets and ISR targets. GO analysis revealed that these\ntargets focused on multiple ISR-related biological processes, including cell proliferation and migration, cell\nadhesion, inflammatory response, and anti-thrombosis and so on. The KEGG enrichment results suggested\nthat PNS could regulate multiple signaling pathways to inhibit or delay the development and occurrence of\nISR. The molecular docking and cellular experiments results verified the network pharmacology results.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>This study demonstrated that the potential molecular mechanisms of PNS for ISR prevention\ninvolved multiple compounds, targets, and pathways. These findings provide a theoretical reference and\nexperimental basis for the clinical application and product development of PNS for the prevention of ISR.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0113816128255082230920071237","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T08:35:07Z","timestamp":1696840507000},"page":"2239-2257","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Integrating Network Pharmacology and Experimental Verification to Explore the\nTargets and Mechanism for Panax Notoginseng Saponins against Coronary In-stent\nRestenosis"],"prefix":"10.2174","volume":"29","author":[{"given":"Yuanchao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of\nMedicine, Shanghai 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University of Chinese\nMedicine, Nanjing Jiangsu 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of\nMedicine, Shanghai 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of\nMedicine, Shanghai 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1093\/eurheartj\/ehv511","volume":"36","author":"Byrne R.A.","year":"2015","unstructured":"Byrne R.A.; Joner M.; Kastrati A.; Stent thrombosis and restenosis: What have we learned and where are we going? 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