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Overlapping targets were subjected to Protein-Protein Interaction (PPI) analysis via the STRING platform,\nfollowed by network analysis using Cytoscape software and the MCODE plugin to identify key protein\ntargets. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment\nanalyses were conducted through the DAVID database to determine relevant biological processes and pathways.\nFinally, molecular docking was performed to assess the binding affinity between the key active components\nof SGR and critical target and pathway proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 15 active components and 527 potential targets of SGR were identified, along with 367\ntargets related to periodontitis. The 75 overlapping targets were considered potential therapeutic targets. Key\ngenes, such as IL-6, IL-1\u03b2, and TNF, were identified through Cytoscape analysis. KEGG enrichment analysis\nindicated that the overlapping targets are primarily involved in inflammatory and metabolic pathways, including\nthe AGE-RAGE signaling pathway, the lipid and atherosclerosis pathway, and the TNF signaling pathway.\nMolecular docking results showed that the key active components can stably bind to the critical targets\nand pathway proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>SGR may have particular advantages in treating periodontitis in patients with systemic diseases,\nsuch as diabetes and cardiovascular conditions, but further research is needed to validate its clinical efficacy\nand safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlights the therapeutic potential of SGR in the treatment of periodontitis and elucidates\nits possible molecular mechanisms, offering new insights and targets for periodontitis therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0113816128391490250729102829","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T06:12:20Z","timestamp":1755065540000},"page":"1362-1373","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Potential Mechanism of Smilax Glabra Roxb in Periodontitis Through Network Pharmacology and Molecular Docking"],"prefix":"10.2174","volume":"32","author":[{"given":"Jinjia","family":"Hong","sequence":"first","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China"},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilun","family":"Ma","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China"},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China"},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China"},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrui","family":"Tian","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China"},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukang","family":"Cao","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China"},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China"},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.7150\/thno.65694","volume":"12","author":"Chen Y.","year":"2022","unstructured":"Chen Y.; Wang H.; Yang Q.; Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis. 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