{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:29:53Z","timestamp":1787056193172,"version":"build-2736575974"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPD"],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>Imatinib, a Tyrosine Kinase Inhibitor (TKI) that targets the first-in-class, has been a major factor in\nthe change of cancer treatment aimed at precision by selectively blocking Breakpoint Cluster Region-Abelson\nmurine leukemia viral oncogene (BCR-ABL), KIT proto-oncogene receptor tyrosine kinase (c-KIT), and\nplatelet-Derived Growth Factor Receptors (PDGFRs), along with additional inhibitory activity against Src\nFamily Kinases (SFKs). Apart from Chronic Myeloid Leukemia (CML), for which it was first approved, clinicians\nhave now expanded its application to include Gastrointestinal Stromal Tumors (GIST), Dermatofibrosarcoma\nProtuberans (DFSP), and kinase-driven cancers of various types. Imatinib inhibits phosphorylation\nand activation of cancer pathways by competitively binding to the ATP-binding site on these kinases. Inhibiting\nBCR-ABL thus deprives the leukemic cells of growth and survival signals. In the same way, inhibition of\nc-KIT and PDGFR results in GIST and DFSP tumor growth retardation through the impact on signaling\npathways like PI3K\/AKT (cell survival and proliferation), RAS\/MAPK (tumor growth and differentiation),\nand JAK\/STAT (immune evasion and cytokine signaling). Moreover, imatinib exerts anti-angiogenic properties\nby lowering the production of pro-angiogenic factors, hence preventing tumor vascularization. However,\nthe drawback of imatinib in the form of resistance issues still hampers the progress of the dominant division.\nThe causes of this phenomenon are secondary mutations, alterations of the kinase domain, activation of alternative\npathways, and clonal evolution. This explores imatinib's inner mechanism in detail, the pivotal role it\nplays in modulating tumor\/stromal cell interactions, as well as the impact that resistance mechanisms have on\nthe therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0113816128488564260713055506","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:50:26Z","timestamp":1787053826000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imatinib: A Multifunctional Tyrosine Kinase Inhibitor with Diverse Mechanisms\nTargeting BCR-ABL, c-KIT, and PDGFR in Cancer Therapy"],"prefix":"10.2174","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1408-6179","authenticated-orcid":true,"given":"Dilpreet","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Applied Sciences, Chitkara University Institute of Engineering &amp; Technology, Chitkara University, Punjab, India"},{"name":"Chemical Research and Development Division, Synthimed Labs Pvt. Ltd, Mohali-160055, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-359X","authenticated-orcid":true,"given":"Sanchit","family":"Dhankhar","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy,Chitkara University, Rajpura-140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3367-613X","authenticated-orcid":true,"given":"Karan","family":"Goel","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy,Chitkara University, Rajpura-140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4120-6534","authenticated-orcid":true,"given":"Samrat","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy,Chitkara University, Rajpura-140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0690-9623","authenticated-orcid":true,"given":"Sumesh Chandra","family":"Sharma","sequence":"additional","affiliation":[{"name":"School of Sciences, RIMT University, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9421-9042","authenticated-orcid":true,"given":"Monika","family":"Saini","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy,Chitkara University, Rajpura-140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-1590","authenticated-orcid":true,"given":"Thakur Gurjeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy,Chitkara University, Rajpura-140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-5475","authenticated-orcid":true,"given":"Somdutt","family":"Mujwar","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy,Chitkara University, Rajpura-140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Pharmaceutical Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113816128488564260713055506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/256923\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113816128488564260713055506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:50:37Z","timestamp":1787053837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/256923\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0113816128488564260713055506","relation":{},"ISSN":["1381-6128"],"issn-type":[{"value":"1381-6128","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2026-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}