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Although this has triggered\ndedicated research in this area, as the disease itself demands a multi-component therapy,\nthere is an unmet need for a compartment and sequential drug delivery system to ameliorate\ndisease symptoms completely. The hypothesized work consists of multitherapeutic agents such\nas an antibiotic, a COX-II inhibitor, an MMP inhibitor, and a bone regenerating agent in an insitu\ngel. However, for the development of the system, as mentioned above, a thorough investigation\nat each stage is necessary; therefore, the quality-by-design approach was adopted.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>Furthermore, the current work is a pursuit of studying the quality by design aspects for the fabrication\nof a compartment system, i.e., in-situ gel for periodontal delivery. The proposed system\nin-situ gel consists of antibiotic and nano-encapsulating microcapsules. Furthermore, the\nmicrocapsules contain a COX-II inhibitor and nanoparticles of MMP inhibitor and bone regenerating\nagent for complete amelioration of periodontitis. To develop the system as per the QbD\napproach, the first initial trials and runs were conducted, which helped to decide the quality target\nproduct profile (QTPP). However, based on QTPP, critical quality attributes (CQA), critical\nprocess parameters (CPP), and critical material attributes (CMAs) were decided for each stage\nproduct, i.e., in-situ gel, microcapsules, and nanoparticles. To assess the influence of CPPs and\nCMAs on CQAs, Pareto charts were constructed, and various risks, along with possible failure\nmodes were studied. In conclusion, the above work will serve as a well-designed scientific\nmouthpiece for developing a compartment system for periodontotherapy.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0113862073281069240409073144","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T12:02:22Z","timestamp":1715860942000},"page":"1320-1330","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["QbD Assisted Development of a Compartment and Sequential Drug Delivery System for Periodontotherapy"],"prefix":"10.2174","volume":"28","author":[{"given":"Pooja","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education and Research, SPER, Jamia Hamdard, New Delhi,\n110062, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeenat","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education and Research, SPER, Jamia Hamdard, New Delhi,\n110062, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.3390\/pharmaceutics13081175","volume":"13","author":"Jain P.","year":"2021","unstructured":"Jain P.; Hassan N.; Khatoon K.; Mirza M.A.; Naseef P.P.; Kuruniyan M.S.; Iqbal Z.; Periodontitis and systemic disorder\u2014an overview of relation and novel treatment modalities. 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