{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T05:08:00Z","timestamp":1758604080380,"version":"3.44.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"16","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCHTS"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n<jats:title>Introduction:<\/jats:title>\n<jats:p>Tobacco use is a major global health issue linked to psychiatric illnesses\nand high mortality rates. Nicotine, the primary compound absorbed during smoking,\ncauses harm to various organs, particularly the brain. The current study examined the modulatory\neffect of Teucrium polium extract (TPE) on nicotine-induced biochemical and histological\nchanges in the brains of mice.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Twenty-four mice were divided into four groups and were treated for three weeks.\nGroup one was the control; Group two received 100 mg\/kg TPE orally; Group three was subcutaneously\ninjected with 2.5 mg\/kg nicotine, and Group four received both nicotine and TPE.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The brain tissue of the nicotine-induced group showed histopathological alterations\nand oxidative stress as indicated by increased lipid peroxidation and nitric oxide levels concomitant\nwith decreased glutathione content and superoxide dismutase activity. DNA fragmentation\nwas also detected by comet assay. Treatment with TPE significantly decreased oxidative stress\nand DNA fragmentation while increasing antioxidant biomarkers. Histopathological changes\nwere also diminished.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Through the antioxidant activity of TPE, it protected against nicotine-induced neurotoxicity\nin mice by impacting oxidative stress, DNA fragmentation, and brain histopathological\nchanges.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0113862073312840240910102115","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T05:09:57Z","timestamp":1727413797000},"page":"2842-2853","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant Properties of Teucrium polium Extract Contribute to Neurochemical and Brain Structural Modulations in Nicotine-Induced Mice"],"prefix":"10.2174","volume":"28","author":[{"given":"Afaf A.","family":"Alatawi","sequence":"first","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamaan S.","family":"Ajarem","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saud A.","family":"Alarifi","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh A.","family":"Al-Quraishy","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esam M.","family":"Al-Shaebi","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Alawwad","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, College of Food and Agricultural Science, King Saud University, P.O. Box\n2460, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashed N.","family":"Herqash","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally M.","family":"Khadrawy","sequence":"additional","affiliation":[{"name":"Genetics and Molecular Biology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanyi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Environmental Science and Engineering, Shaanxi University of Science and Technology, Xi\u2019an 710021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh N.","family":"Maodaa","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Combinatorial Chemistry &amp; High Throughput Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113862073312840240910102115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/234532\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113862073312840240910102115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T04:14:33Z","timestamp":1758600873000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/234532\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":0,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0113862073312840240910102115","relation":{},"ISSN":["1386-2073"],"issn-type":[{"type":"print","value":"1386-2073"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2024-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}