{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:17:24Z","timestamp":1783383444469,"version":"3.54.6"},"reference-count":134,"publisher":"Bentham Science Publishers Ltd.","issue":"9","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDM"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Traditional treatment methods for the management of diabetes, such as oral hypoglycemic medications\nand insulin injections, include drawbacks like systemic adverse effects, inconsistent medication\nlevels, and low compliance. To avoid difficulties, glycemic levels in diabetic patients, a long-term metabolic\ncondition, must be precisely and consistently controlled. Smart therapeutic systems allow for precise,\non-demand medication release in response to local physiological or environmental cues, such as glucose\nlevels, pH, temperature, or enzyme activity. They provide a possible substitute for conventional diabetic\ntherapies. As these systems only administer medications when and where needed, they reduce side effects\nwhile simultaneously increasing therapeutic efficacy and patient compliance. These systems are designed\nto respond to signals from external sources (such as light, ultrasound, or magnetic fields) or stimuli like\ntemperature, pH, glucose levels, and enzymes. As they use glucose-sensitive substances like phenylboronic\nacid, glucose oxidase, or polymers to precisely release insulin in hyperglycemic circumstances,\nglucose-responsive delivery methods are essential for diabetes. This review discusses a stimuli-responsive\ndrug delivery system designed for diabetes treatment, with a focus on the developments in biomaterials,\nnanotechnology, and engineering that improve its effectiveness and biocompatibility. Along with the possibility\nof combining a stimuli-responsive drug delivery system with wearable technology for continuous\nglucose monitoring and intelligent insulin delivery, issues, such as manufacturing complexity, stability,\nand patient safety, are also addressed. The stimuli-responsive drug delivery system has the potential to\nrevolutionize diabetes management by bridging the gap between physiological needs and therapeutic delivery,\nproviding better glucose control, fewer side effects, and an enhanced standard of living for patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0113892002390554251015114414","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T04:06:31Z","timestamp":1762401991000},"page":"600-617","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Smart Stimuli-Responsive Drug Delivery Systems for Advanced Diabetes Management"],"prefix":"10.2174","volume":"26","author":[{"given":"Km. Preeti","family":"Jaiswal","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh 201306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0528-6119","authenticated-orcid":true,"family":"Monika","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh 201306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupa","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh 201306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avijit","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh 201306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"e43697","DOI":"10.7759\/cureus.43697","volume":"15","author":"Sugandh F.N.U.","year":"2023","unstructured":"Sugandh F.N.U.; Chandio M.; Raveena F.N.U.; Kumar L.; Karishma F.N.U.; Khuwaja S.; Memon U.A.; Bai K.; Kashif M.; Varrassi G.; Khatri M.; Kumar S.; Advances in the management of diabetes mellitus: A focus on personalized medicine. Cureus  2023,15(8),e43697","journal-title":"Cureus"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jconrel.2014.06.035","volume":"190","author":"Siegel R.A.","year":"2014","unstructured":"Siegel R.A.; Stimuli sensitive polymers and self regulated drug delivery systems: A very partial review. J Control Release  2014,190,337-351","journal-title":"J Control Release"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/978-981-99-6698-1_18","author":"Trehan K.","year":"2023","unstructured":"Trehan K.; Saini M.; Thakur S.; Stimuli-responsive material in controlled release of drug. Engineered Biomaterials  2023,535-561","journal-title":"Engineered Biomaterials"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"166","DOI":"10.2174\/2468187306666160712232449","volume":"6","author":"Naziris N.","year":"2016","unstructured":"Naziris N.; Pippa N.; Pispas S.; Demetzos C.; Stimuli-responsive drug delivery nanosystems: From bench to clinic. Curr Nanomed  2016,6(3),166-185","journal-title":"Curr Nanomed"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3390\/bios12060385","volume":"12","author":"Polat E.O.","year":"2022","unstructured":"Polat E.O.; Cetin M.M.; Tabak A.F.; Bilget G\u00fcven E.; Uysal B.\u00d6.; Arsan T.; Kabbani A.; Hamed H.; G\u00fcl S.B.; Transducer technologies for biosensors and their wearable applications. Biosensors  2022,12(6),385","journal-title":"Biosensors"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.bcab.2018.11.029","volume":"17","author":"Metkar S.K.","year":"2019","unstructured":"Metkar S.K.; Girigoswami K.; Diagnostic biosensors in medicine \u2013 A review. Biocatal Agric Biotechnol  2019,17,271-283","journal-title":"Biocatal Agric Biotechnol"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.3390\/biom12091198","volume":"12","author":"Cicha I.","year":"2022","unstructured":"Cicha I.; Priefer R.; Severino P.; Souto E.B.; Jain S.; Biosensor-integrated drug delivery systems as new materials for biomedical applications. Biomolecules  2022,12(9),1198","journal-title":"Biomolecules"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"166","DOI":"10.2174\/1381612825666190306153838","volume":"25","author":"Zaric B.L.","year":"2019","unstructured":"Zaric B.L.; Obradovic M.; Sudar-Milovanovic E.; Nedeljkovic J.; Lazic V.; Isenovic E.R.; Drug delivery systems for diabetes treatment. Curr Pharm Des  2019,25(2),166-173","journal-title":"Curr Pharm Des"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/S0140-6736(05)61032-X","volume":"365","author":"Stumvoll M.","year":"2005","unstructured":"Stumvoll M.; Goldstein B.J.; van Haeften T.W.; Type 2 diabetes: Principles of pathogenesis and therapy. Lancet  2005,365(9467),1333-1346","journal-title":"Lancet"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/B978-0-08-101995-5.00021-0","author":"Mukhopadhyay P.","year":"2019","unstructured":"Mukhopadhyay P.; Kundu P.P.;  Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications  2019,525-546","journal-title":"Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1039\/b607706d","volume":"2","author":"Mart R.J.","year":"2006","unstructured":"Mart R.J.; Osborne R.D.; Stevens M.M.; Ulijn R.V.; Peptide-based stimuli-responsive biomaterials. Soft Matter  2006,2(10),822-835","journal-title":"Soft Matter"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"100031","DOI":"10.1016\/j.onano.2021.100031","volume":"5","author":"Mu Y.","year":"2021","unstructured":"Mu Y.; Gong L.; Peng T.; Yao J.; Lin Z.; Advances in pH-responsive drug delivery systems. OpenNano  2021,5,100031","journal-title":"OpenNano"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nri2925","volume":"11","author":"Donath M.Y.","year":"2011","unstructured":"Donath M.Y.; Shoelson S.E.; Type 2 diabetes as an inflammatory disease. Nat Rev Immunol  2011,11(2),98-107","journal-title":"Nat Rev Immunol"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1056\/NEJMcp1013127","volume":"366","author":"Ismail-Beigi F.","year":"2012","unstructured":"Ismail-Beigi F.; Clinical practice. Glycemic management of type 2 diabetes mellitus. N Engl J Med  2012,366(14),1319-1327","journal-title":"N Engl J Med"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"343","DOI":"10.2174\/1573399810666141124110836","volume":"10","author":"Rao R.","year":"2015","unstructured":"Rao R.; Mahant S.; Chhabra L.; Nanda S.; Transdermal innovations in diabetes management. Curr Diabetes Rev  2015,10(6),343-359","journal-title":"Curr Diabetes Rev"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.21276\/IJRDPL.2278-0238.2018.7(4).3030-3033","volume":"7","author":"Chaudhary N.","year":"2018","unstructured":"Chaudhary N.; Tyagi N.; Diabetes mellitus: An overview. Int J Res Dev Pharm Life Sci  2018,7(4),3030-3033","journal-title":"Int J Res Dev Pharm Life Sci"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"3610","DOI":"10.47750\/pnr.2022.13.S08.448","volume":"13","author":"Perada S.","year":"2022","unstructured":"Perada S.; Murthy P.N.; Design, development and evaluation of transdermal drug delivery system for treatment of diabetes. J Pharm Negat Results  2022,13(special issue 08),3610-3617","journal-title":"J Pharm Negat Results"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3390\/pharmaceutics10030136","volume":"10","author":"Alsuraifi A.","year":"2018","unstructured":"Alsuraifi A.; Curtis A.; Lamprou D.A.; Hoskins C.; Stimuli responsive polymeric systems for cancer therapy. Pharmaceutics  2018,10(3),136","journal-title":"Pharmaceutics"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.3390\/biomedicines10102436","volume":"10","author":"Aloke C.","year":"2022","unstructured":"Aloke C.; Egwu C.O.; Aja P.M.; Obasi N.A.; Chukwu J.; Akumadu B.O.; Ogbu P.N.; Achilonu I.; Current advances in the management of diabetes mellitus. Biomedicines  2022,10(10),2436","journal-title":"Biomedicines"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1021\/acsmaterialsau.4c00138","volume":"5","author":"Pal S.","year":"2025","unstructured":"Pal S.; Rakshit T.; Saha S.; Jinagal D.; Glucose-responsive materials for smart insulin delivery: from protein-based to protein-free design. ACS Mater Au  2025,5(2),239-252","journal-title":"ACS Mater Au"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jconrel.2020.02.014","volume":"321","author":"Shen D.","year":"2020","unstructured":"Shen D.; Yu H.; Wang L.; Khan A.; Haq F.; Chen X.; Huang Q.; Teng L.; Recent progress in design and preparation of glucose-responsive insulin delivery systems. J Control Release  2020,321,236-258","journal-title":"J Control Release"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"69152","DOI":"10.1039\/C5RA07082A","volume":"5","author":"Rostamizadeh K.","year":"2015","unstructured":"Rostamizadeh K.; Rezaei S.; Abdouss M.; Sadighian S.; Arish S.; A hybrid modeling approach for optimization of PMAA\u2013chitosan\u2013PEG nanoparticles for oral insulin delivery. RSC Advances  2015,5(85),69152-69160","journal-title":"RSC Advances"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1021\/ar200234q","volume":"45","author":"Sung H.W.","year":"2012","unstructured":"Sung H.W.; Sonaje K.; Liao Z.X.; Hsu L.W.; Chuang E.Y.; pH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: From mechanism to therapeutic applications. Acc Chem Res  2012,45(4),619-629","journal-title":"Acc Chem Res"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1021\/bm0607776","volume":"8","author":"Lin Y.H.","year":"2007","unstructured":"Lin Y.H.; Mi F.L.; Chen C.T.; Chang W.C.; Peng S.F.; Liang H.F.; Sung H.W.; Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery. Biomacromolecules  2007,8(1),146-152","journal-title":"Biomacromolecules"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jconrel.2022.05.056","volume":"348","author":"Ding H.","year":"2022","unstructured":"Ding H.; Tan P.; Fu S.; Tian X.; Zhang H.; Ma X.; Gu Z.; Luo K.; Preparation and application of pH-responsive drug delivery systems. J Control Release  2022,348,206-238","journal-title":"J Control Release"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3390\/jfb10030034","volume":"10","author":"Wells C.M.","year":"2019","unstructured":"Wells C.M.; Harris M.; Choi L.; Murali V.P.; Guerra F.D.; Jennings J.A.; Stimuli-responsive drug release from smart polymers. J Funct Biomater  2019,10(3),34","journal-title":"J Funct Biomater"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1021\/acs.macromol.5b00360","volume":"48","author":"Laaser J.E.","year":"2015","unstructured":"Laaser J.E.; Jiang Y.; Sprouse D.; Reineke T.M.; Lodge T.P.; pH-and ionic-strength-induced contraction of polybasic micelles in buffered aqueous solutions. Macromolecules  2015,48(8),2677-2685","journal-title":"Macromolecules"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1517\/17425247.2013.821978","volume":"10","author":"Yoshida T.","year":"2013","unstructured":"Yoshida T.; Lai T.C.; Kwon G.S.; Sako K.; pH- and ion-sensitive polymers for drug delivery. Expert Opin Drug Deliv  2013,10(11),1497-1513","journal-title":"Expert Opin Drug Deliv"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.3390\/biomedicines11092545","volume":"11","author":"Mansoor S.","year":"2023","unstructured":"Mansoor S.; Adeyemi S.A.; Kondiah P.P.D.; Choonara Y.E.; A Closed loop stimuli-responsive concanavalin a-loaded chitosan\u2013pluronic hydrogel for glucose-responsive delivery of short-acting insulin prototyped in RIN-5F pancreatic cells. Biomedicines  2023,11(9),2545","journal-title":"Biomedicines"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nrd4477","volume":"14","author":"Veiseh O.","year":"2015","unstructured":"Veiseh O.; Tang B.C.; Whitehead K.A.; Anderson D.G.; Langer R.; Managing diabetes with nanomedicine: Challenges and opportunities. Nat Rev Drug Discov  2015,14(1),45-57","journal-title":"Nat Rev Drug Discov"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1039\/c3cs60436e","volume":"43","author":"Mo R.","year":"2014","unstructured":"Mo R.; Jiang T.; Di J.; Tai W.; Gu Z.; Emerging micro- and nanotechnology based synthetic approaches for insulin delivery. Chem Soc Rev  2014,43(10),3595-3629","journal-title":"Chem Soc Rev"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"662","DOI":"10.3390\/gels9080662","volume":"9","author":"Cao J.","year":"2023","unstructured":"Cao J.; Yuan P.; Wu B.; Liu Y.; Hu C.; Advances in the research and application of smart-responsive hydrogels in disease treatment. Gels  2023,9(8),662","journal-title":"Gels"},{"key":"ref=33","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1007\/s11356-021-17346-0","volume":"29","author":"Zahoor I.","year":"2022","unstructured":"Zahoor I.; Singh S.; Behl T.; Sharma N.; Naved T.; Subramaniyan V.; Fuloria S.; Fuloria N.K.; Bhatia S.; Al-Harrasi A.; Aleya L.; Emergence of microneedles as a potential therapeutics in diabetes mellitus. Environ Sci Pollut Res Int  2022,29(3),3302-3322","journal-title":"Environ Sci Pollut Res Int"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"2210392","DOI":"10.1002\/adma.202210392","volume":"35","author":"Xu R.","year":"2023","unstructured":"Xu R.; Bhangu S.K.; Sourris K.C.; Vanni D.; Sani M.A.; Karas J.A.; Alt K.; Niego B.; Ale A.; Besford Q.A.; Dyett B.; Patrick J.; Carmichael I.; Shaw J.E.; Caruso F.; Cooper M.E.; Hagemeyer C.E.; Cavalieri F.; An engineered nanosugar enables rapid and sustained glucose\u2010responsive insulin delivery in diabetic mice. Adv Mater  2023,35(21),2210392","journal-title":"Adv Mater"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"10538","DOI":"10.1039\/D3TB01712E","volume":"11","author":"Damiri F.","year":"2023","unstructured":"Damiri F.; Fatimi A.; Santos A.C.P.; Varma R.S.; Berrada M.; Smart stimuli-responsive polysaccharide nanohydrogels for drug delivery: A review. J Mater Chem B Mater Biol Med  2023,11(44),10538-10565","journal-title":"J Mater Chem B Mater Biol Med"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"130301","DOI":"10.1016\/j.ijbiomac.2024.130301","volume":"263","author":"Mart\u00ednez-Navarrete M.","year":"2024","unstructured":"Mart\u00ednez-Navarrete M.; P\u00e9rez-L\u00f3pez A.; Guillot A.J.; Cordeiro A.S.; Melero A.; Aparicio-Blanco J.; Latest advances in glucose-responsive microneedle-based systems for transdermal insulin delivery. Int J Biol Macromol  2024,263(Pt 2),130301","journal-title":"Int J Biol Macromol"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1073\/pnas.1424684112","volume":"112","author":"Chou D.H.C.","year":"2015","unstructured":"Chou D.H.C.; Webber M.J.; Tang B.C.; Lin A.B.; Thapa L.S.; Deng D.; Truong J.V.; Cortinas A.B.; Langer R.; Anderson D.G.; Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates. Proc Natl Acad Sci USA  2015,112(8),2401-2406","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jconrel.2020.01.038","volume":"320","author":"Zhang C.","year":"2020","unstructured":"Zhang C.; Hong S.; Liu M.D.; Yu W.Y.; Zhang M.K.; Zhang L.; Zeng X.; Zhang X.Z.; pH-sensitive MOF integrated with glucose oxidase for glucose-responsive insulin delivery. J Control Release  2020,320,159-167","journal-title":"J Control Release"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"111217","DOI":"10.1016\/j.eurpolymj.2022.111217","volume":"173","author":"Zong Q.","year":"2022","unstructured":"Zong Q.; Zhou R.; Zhao Z.; Wang Y.; Liu C.; Zhang P.; Glucose-responsive insulin microneedle patch based on phenylboronic acid for 1 diabetes treatment. Eur Polym J  2022,173,111217","journal-title":"Eur Polym J"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1021\/accountsmr.2c00094","volume":"3","author":"Yao Y.","year":"2022","unstructured":"Yao Y.; Ji K.; Wang Y.; Gu Z.; Wang J.; Materials and carriers development for glucose-responsive insulin. Acc Mater Res  2022,3(9),960-970","journal-title":"Acc Mater Res"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.3390\/ijms23084421","volume":"23","author":"Sobczak M.","year":"2022","unstructured":"Sobczak M.; Enzyme-responsive hydrogels as potential drug delivery systems\u2014state of knowledge and future prospects. Int J Mol Sci  2022,23(8),4421","journal-title":"Int J Mol Sci"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"16614","DOI":"10.1021\/ja9061085","volume":"131","author":"Park C.","year":"2009","unstructured":"Park C.; Kim H.; Kim S.; Kim C.; Enzyme responsive nanocontainers with cyclodextrin gatekeepers and synergistic effects in release of guests. J Am Chem Soc  2009,131(46),16614-16615","journal-title":"J Am Chem Soc"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.3390\/pharmaceutics16101343","volume":"16","author":"Liu J.","year":"2024","unstructured":"Liu J.; Yi X.; Zhang J.; Yao Y.; Panichayupakaranant P.; Chen H.; Recent advances in the drugs and glucose-responsive drug delivery systems for the treatment of diabetes: A systematic review. Pharmaceutics  2024,16(10),1343","journal-title":"Pharmaceutics"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"466","DOI":"10.15212\/AMM-2025-0019","volume":"4","author":"Hulambukie E.","year":"2025","unstructured":"Hulambukie E.; Liu M.; Wu W.; Xiang X.; Hanning S.; Wen J.; Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems. Acta Materia Med  2025,4(3),466-492","journal-title":"Acta Materia Med"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.jconrel.2014.05.002","volume":"190","author":"Jhaveri A.","year":"2014","unstructured":"Jhaveri A.; Deshpande P.; Torchilin V.; Stimuli-sensitive nanopreparations for combination cancer therapy. J Control Release  2014,190,352-370","journal-title":"J Control Release"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1039\/C5CS00798D","volume":"45","author":"Karimi M.","year":"2016","unstructured":"Karimi M.; Ghasemi A.; Sahandi Zangabad P.; Rahighi R.; Moosavi Basri S.M.; Mirshekari H.; Amiri M.; Shafaei Pishabad Z.; Aslani A.; Bozorgomid M.; Ghosh D.; Beyzavi A.; Vaseghi A.; Aref A.R.; Haghani L.; Bahrami S.; Hamblin M.R.; Smart micro\/nanoparticles in stimulus-responsive drug\/gene delivery systems. Chem Soc Rev  2016,45(5),1457-1501","journal-title":"Chem Soc Rev"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"816","DOI":"10.2174\/1381612826666201019102640","volume":"27","author":"Korivi M.","year":"2021","unstructured":"Korivi M.; Huang Y.W.; Liu B.R.; Cell-penetrating peptides as a potential drug delivery system for effective treatment of diabetes. Curr Pharm Des  2021,27(6),816-825","journal-title":"Curr Pharm Des"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/B978-0-08-101997-9.00009-6","author":"Johnson R.P.","year":"2018","unstructured":"Johnson R.P.; Preman N.K.; Responsive block copolymers for drug delivery applications. Part 1: Endogenous stimuli-responsive drug-release systems. Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications, Volume 1  2018,171-220","journal-title":"Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications, Volume 1"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1007\/s13346-021-01113-2","volume":"12","author":"Li W.X.","year":"2022","unstructured":"Li W.X.; Zhang X.P.; Chen B.Z.; Fei W.M.; Cui Y.; Zhang C.Y.; Guo X.D.; An update on microneedle-based systems for diabetes. Drug Deliv Transl Res  2022,12(10),2275-2286","journal-title":"Drug Deliv Transl Res"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"120591","DOI":"10.1016\/j.ijpharm.2021.120591","volume":"602","author":"Lin X.","year":"2021","unstructured":"Lin X.; Wu X.; Chen X.; Wang B.; Xu W.; Intellective and stimuli-responsive drug delivery systems in eyes. Int J Pharm  2021,602,120591","journal-title":"Int J Pharm"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.smaim.2022.08.003","volume":"4","author":"Singh K.","year":"2023","unstructured":"Singh K.; Agarwal T.; Kumar U.; Pal S.; Runthala A.; Pan T.M.; Wu C.C.; Optical biosensors for diabetes management: Advancing into stimuli-responsive sensing mechanisms. Smart Mater Med  2023,4,91-101","journal-title":"Smart Mater Med"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"12967","DOI":"10.1039\/D2NR03756D","volume":"14","author":"Hu Y.","year":"2022","unstructured":"Hu Y.; Li H.; Lv X.; Xu Y.; Xie Y.; Yuwen L.; Song Y.; Li S.; Shao J.; Yang D.; Stimuli-responsive therapeutic systems for the treatment of diabetic infected wounds. Nanoscale  2022,14(36),12967-12983","journal-title":"Nanoscale"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"838","DOI":"10.3390\/gels9100838","volume":"9","author":"Zhang Y.","year":"2023","unstructured":"Zhang Y.; Wu B.M.; Current advances in stimuli-responsive hydrogels as smart drug delivery carriers. Gels  2023,9(10),838","journal-title":"Gels"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/nbt.1504","volume":"26","author":"Prausnitz M.R.","year":"2008","unstructured":"Prausnitz M.R.; Langer R.; Transdermal drug delivery. Nat Biotechnol  2008,26(11),1261-1268","journal-title":"Nat Biotechnol"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1007\/s10439-022-02994-1","volume":"50","author":"Bao H.","year":"2022","unstructured":"Bao H.; Chen J.; Wang X.; Chen C.; Gong J.; Liu J.; Xia D.; Ultrasound-triggered on-demand insulin release for diabetes mellitus treatment. Ann Biomed Eng  2022,50(12),1826-1836","journal-title":"Ann Biomed Eng"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1007\/s11095-007-9306-4","volume":"24","author":"Park E.J.","year":"2007","unstructured":"Park E.J.; Werner J.; Smith N.B.; Ultrasound mediated transdermal insulin delivery in pigs using a lightweight transducer. Pharm Res  2007,24(7),1396-1401","journal-title":"Pharm Res"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1002\/adhm.201300490","volume":"3","author":"Di J.","year":"2014","unstructured":"Di J.; Price J.; Gu X.; Jiang X.; Jing Y.; Gu Z.; Ultrasound-triggered regulation of blood glucose levels using injectable nano-network. Adv Healthc Mater  2014,3(6),811-816","journal-title":"Adv Healthc Mater"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1080\/17425247.2022.2110585","volume":"19","author":"Fan C.H.","year":"2022","unstructured":"Fan C.H.; Ho Y.J.; Lin C.W.; Wu N.; Chiang P.H.; Yeh C.K.; State-of-the-art of ultrasound-triggered drug delivery from ultrasound-responsive drug carriers. Expert Opin Drug Deliv  2022,19(8),997-1009","journal-title":"Expert Opin Drug Deliv"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.2147\/IJN.S374247","volume":"17","author":"Sun Y.","year":"2022","unstructured":"Sun Y.; Chen L.G.; Fan X.M.; Pang J.L.; Ultrasound responsive smart implantable hydrogels for targeted delivery of drugs: Reviewing current practices. Int J Nanomedicine  2022,17,5001-5026","journal-title":"Int J Nanomedicine"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ejpb.2007.02.025","volume":"68","author":"Klouda L.","year":"2008","unstructured":"Klouda L.; Mikos A.G.; Thermoresponsive hydrogels in biomedical applications. Eur J Pharm Biopharm  2008,68(1),34-45","journal-title":"Eur J Pharm Biopharm"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1007\/s11095-011-0380-2","volume":"28","author":"Lima A.C.","year":"2011","unstructured":"Lima A.C.; Song W.; Blanco-Fernandez B.; Alvarez-Lorenzo C.; Mano J.F.; Synthesis of temperature-responsive dextran-MA\/PNIPAAm particles for controlled drug delivery using superhydrophobic surfaces. Pharm Res  2011,28(6),1294-1305","journal-title":"Pharm Res"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"2100194","DOI":"10.1002\/adhm.202100194","volume":"10","author":"Zhang J.","year":"2021","unstructured":"Zhang J.; Xu J.; Lim J.; Nolan J.K.; Lee H.; Lee C.H.; Wearable glucose monitoring and implantable drug delivery systems for diabetes management. Adv Healthc Mater  2021,10(17),2100194","journal-title":"Adv Healthc Mater"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ajps.2014.08.010","volume":"10","author":"Gandhi A.","year":"2015","unstructured":"Gandhi A.; Paul A.; Sen S.O.; Sen K.K.; Studies on thermoresponsive polymers: Phase behaviour, drug delivery and biomedical applications. Asian J Pharm Sci  2015,10(2),99-107","journal-title":"Asian J Pharm Sci"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.actbio.2022.08.061","volume":"153","author":"Li J.Y.","year":"2022","unstructured":"Li J.Y.; Feng Y.H.; He Y.T.; Hu L.F.; Liang L.; Zhao Z.Q.; Chen B.Z.; Guo X.D.; Thermosensitive hydrogel microneedles for controlled transdermal drug delivery. Acta Biomater  2022,153,308-319","journal-title":"Acta Biomater"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.3390\/polym13132086","volume":"13","author":"Chatterjee S.","year":"2021","unstructured":"Chatterjee S.; Hui P.C.; Review of applications and future prospects of stimuli-responsive hydrogel based on thermo-responsive biopolymers in drug delivery systems. Polymers  2021,13(13),2086","journal-title":"Polymers"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.apsb.2014.02.005","volume":"4","author":"Priya James H.","year":"2014","unstructured":"Priya James H.; John R.; Alex A.; Anoop K.R.; Smart polymers for the controlled delivery of drugs \u2013 A concise overview. Acta Pharm Sin B  2014,4(2),120-127","journal-title":"Acta Pharm Sin B"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/nmat3776","volume":"12","author":"Mura S.","year":"2013","unstructured":"Mura S.; Nicolas J.; Couvreur P.; Stimuli-responsive nanocarriers for drug delivery. Nat Mater  2013,12(11),991-1003","journal-title":"Nat Mater"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.smaim.2024.08.004","volume":"5","author":"Hu H.","year":"2024","unstructured":"Hu H.; Busa P.; Zhao Y.; Zhao C.; Externally triggered drug delivery systems. Smart Mater Med  2024,5(3),386-408","journal-title":"Smart Mater Med"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"134354","DOI":"10.1016\/j.cej.2021.134354","volume":"432","author":"Le M.","year":"2022","unstructured":"Le M.; Huang W.; Chen K.F.; Lin C.; Cai L.; Zhang H.; Jia Y.G.; Upper critical solution temperature polymeric drug carriers. Chem Eng J  2022,432,134354","journal-title":"Chem Eng J"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/736898","volume":"2014","author":"Liu Y.","year":"2014","unstructured":"Liu Y.; Yan K.; Jiang G.; Xiong Y.; Du Y.; Shi X.; Electrical signal guided ibuprofen release from electrodeposited chitosan hydrogel. Int J Polym Sci  2014,2014(1),1-8","journal-title":"Int J Polym Sci"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"122ra21","DOI":"10.1126\/scitranslmed.3003276","volume":"4","author":"Farra R.","year":"2012","unstructured":"Farra R.; Sheppard N.F.; McCabe L.; Neer R.M.; Anderson J.M.; Santini J.T.; Cima M.J.; Langer R.; First-in-human testing of a wirelessly controlled drug delivery microchip. Sci Transl Med  2012,4(122),122ra21","journal-title":"Sci Transl Med"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"124684","DOI":"10.1016\/j.ijbiomac.2023.124684","volume":"242","author":"Qi Z.","year":"2023","unstructured":"Qi Z.; Tao X.; Tan G.; Tian B.; Zhang L.; Kundu S.C.; Lu S.; Electro-responsive silk fibroin microneedles for controlled release of insulin. Int J Biol Macromol  2023,242(Pt 1),124684","journal-title":"Int J Biol Macromol"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"104922","DOI":"10.1016\/j.jddst.2023.104922","volume":"88","author":"Liu R.","year":"2023","unstructured":"Liu R.; Li A.; Lang Y.; Cai H.; Tang X.; Li D.; Liu X.; Liu J.; Stimuli-responsive polymer microneedles: A rising transdermal drug delivery system and Its applications in biomedical. J Drug Deliv Sci Technol  2023,88,104922","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2174\/187221407779814598","volume":"1","author":"Anal A.","year":"2007","unstructured":"Anal A.; Stimuli-induced pulsatile or triggered release delivery systems for bioactive compounds. Recent Pat Endocr Metab Immune Drug Discov  2007,1(1),83-90","journal-title":"Recent Pat Endocr Metab Immune Drug Discov"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1021\/nn203430m","volume":"6","author":"Ge J.","year":"2012","unstructured":"Ge J.; Neofytou E.; Cahill T.J.; Beygui R.E.; Zare R.N.; Drug release from electric-field-responsive nanoparticles. ACS Nano  2012,6(1),227-233","journal-title":"ACS Nano"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1016\/j.biomaterials.2009.11.004","volume":"31","author":"Im J.S.","year":"2010","unstructured":"Im J.S.; Bai B.C.; Lee Y.S.; The effect of carbon nanotubes on drug delivery in an electro-sensitive transdermal drug delivery system. Biomaterials  2010,31(6),1414-1419","journal-title":"Biomaterials"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"9268","DOI":"10.1021\/ja1027502","volume":"132","author":"Yan Q.","year":"2010","unstructured":"Yan Q.; Yuan J.; Cai Z.; Xin Y.; Kang Y.; Yin Y.; Voltage-responsive vesicles based on orthogonal assembly of two homopolymers. J Am Chem Soc  2010,132(27),9268-9270","journal-title":"J Am Chem Soc"},{"key":"ref=78","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1021\/acs.biomac.1c01691","volume":"23","author":"Gowda B.H.J.","year":"2022","unstructured":"Gowda B.H.J.; Ahmed M.G.; Sahebkar A.; Riadi Y.; Shukla R.; Kesharwani P.; Stimuli-responsive microneedles as a transdermal drug delivery system: A demand-supply strategy. Biomacromolecules  2022,23(4),1519-1544","journal-title":"Biomacromolecules"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.colsurfb.2015.01.003","volume":"126","author":"Shamaeli E.","year":"2015","unstructured":"Shamaeli E.; Alizadeh N.; Functionalized gold nanoparticle-polypyrrole nanobiocomposite with high effective surface area for electrochemical\/pH dual stimuli-responsive smart release of insulin. Colloids Surf B Biointerfaces  2015,126,502-509","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"2100055","DOI":"10.1002\/admt.202100055","volume":"7","author":"Xu L.","year":"2022","unstructured":"Xu L.; Yang Y.; Mao Y.; Li Z.; Self\u2010powerbility in electrical stimulation drug delivery system. Adv Mater Technol  2022,7(2),2100055","journal-title":"Adv Mater Technol"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1039\/C6TB00049E","volume":"4","author":"Zhao Y.","year":"2016","unstructured":"Zhao Y.; Tavares A.C.; Gauthier M.A.; Nano-engineered electro-responsive drug delivery systems. J Mater Chem B Mater Biol Med  2016,4(18),3019-3030","journal-title":"J Mater Chem B Mater Biol Med"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0969-806X(00)00381-9","volume":"61","author":"Sutani K.","year":"2001","unstructured":"Sutani K.; Kaetsu I.; Uchida K.; The synthesis and the electric-responsiveness of hydrogels entrapping natural polyelectrolyte. Radiat Phys Chem  2001,61(1),49-54","journal-title":"Radiat Phys Chem"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"1902004","DOI":"10.1002\/adma.201902004","volume":"32","author":"Wang J.","year":"2020","unstructured":"Wang J.; Wang Z.; Yu J.; Kahkoska A.R.; Buse J.B.; Gu Z.; Glucose\u2010responsive insulin and delivery systems: Innovation and translation. Adv Mater  2020,32(13),1902004","journal-title":"Adv Mater"},{"key":"ref=84","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/S1470-2045(18)30332-2","volume":"19","author":"Lyon P.C.","year":"2018","unstructured":"Lyon P.C.; Gray M.D.; Mannaris C.; Folkes L.K.; Stratford M.; Campo L.; Chung D.Y.F.; Scott S.; Anderson M.; Goldin R.; Carlisle R.; Wu F.; Middleton M.R.; Gleeson F.V.; Coussios C.C.; Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): A single-centre, open-label, phase 1 trial. Lancet Oncol  2018,19(8),1027-1039","journal-title":"Lancet Oncol"},{"key":"ref=85","doi-asserted-by":"publisher","first-page":"7490","DOI":"10.1021\/acs.macromol.6b01760","volume":"49","author":"Chen S.","year":"2016","unstructured":"Chen S.; Gao Y.; Cao Z.; Wu B.; Wang L.; Wang H.; Dang Z.; Wang G.; Nanocomposites of spiropyran-functionalized polymers and upconversion nanoparticles for controlled release stimulated by near-infrared light and pH. Macromolecules  2016,49(19),7490-7496","journal-title":"Macromolecules"},{"key":"ref=86","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1021\/la204930n","volume":"28","author":"Han D.","year":"2012","unstructured":"Han D.; Tong X.; Zhao Y.; Block copolymer micelles with a dual-stimuli-responsive core for fast or slow degradation. Langmuir  2012,28(5),2327-2331","journal-title":"Langmuir"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"89","DOI":"10.4155\/tde-2016-0060","volume":"8","author":"Linsley C.S.","year":"2017","unstructured":"Linsley C.S.; Wu B.M.; Recent Advances in light-responsive on-demand drug-delivery Systems. Ther Deliv  2017,8(2),89-107","journal-title":"Ther Deliv"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s10973-009-0228-8","volume":"98","author":"Yavlovich A.","year":"2009","unstructured":"Yavlovich A.; Singh A.; Tarasov S.; Capala J.; Blumenthal R.; Puri A.; Design of liposomes containing photopolymerizable phospholipids for triggered release of contents. J Therm Anal Calorim  2009,98(1),97-104","journal-title":"J Therm Anal Calorim"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"11338","DOI":"10.1002\/anie.201500628","volume":"54","author":"Bl\u00e9ger D.","year":"2015","unstructured":"Bl\u00e9ger D.; Hecht S.; Visible\u2010light\u2010activated molecular switches. Angew Chem Int Ed  2015,54(39),11338-11349","journal-title":"Angew Chem Int Ed"},{"key":"ref=90","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.cis.2013.11.009","volume":"207","author":"Yi Q.","year":"2014","unstructured":"Yi Q.; Sukhorukov G.B.; UV light stimulated encapsulation and release by polyelectrolyte microcapsules. Adv Colloid Interface Sci  2014,207,280-289","journal-title":"Adv Colloid Interface Sci"},{"key":"ref=91","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1039\/9781849736800-00304","author":"Alatorre-Meda M.","year":"2013","unstructured":"Alatorre-Meda M.; Alvarez-Lorenzo C.; Concheiro A.; Taboada P.; Chapter 12: UV and near-IR triggered release from polymeric micelles and nanoparticles. Smart Materials for Drug delivery  2013,304-348","journal-title":"Smart Materials for Drug delivery"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"11475","DOI":"10.1021\/la7019654","volume":"23","author":"Alvarez-Lorenzo C.","year":"2007","unstructured":"Alvarez-Lorenzo C.; Deshmukh S.; Bromberg L.; Hatton T.A.; S\u00e1ndez-Macho I.; Concheiro A.; Temperature- and Light-Responsive Blends of Pluronic F127 and Poly( N, N -dimethylacrylamide- co -methacryloyloxyazobenzene). Langmuir  2007,23(23),11475-11481","journal-title":"Langmuir"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1021\/nl2036047","volume":"12","author":"Schroeder A.","year":"2012","unstructured":"Schroeder A.; Goldberg M.S.; Kastrup C.; Wang Y.; Jiang S.; Joseph B.J.; Levins C.G.; Kannan S.T.; Langer R.; Anderson D.G.; Remotely activated protein-producing nanoparticles. Nano Lett  2012,12(6),2685-2689","journal-title":"Nano Lett"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1002\/polb.23263","volume":"51","author":"Zhang S.","year":"2013","unstructured":"Zhang S.; Li Z.; Stimuli\u2010responsive polypeptide materials prepared by ring\u2010opening polymerization of \u03b1\u2010amino acid N \u2010carboxyanhydrides. J Polym Sci, B, Polym Phys  2013,51(7),546-555","journal-title":"J Polym Sci, B, Polym Phys"},{"key":"ref=95","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.eurpolymj.2015.01.016","volume":"65","author":"Hrub\u00fd M.","year":"2015","unstructured":"Hrub\u00fd M.; Filippov S.K.; \u0160t\u011bp\u00e1nek P.; Smart polymers in drug delivery systems on crossroads: Which way deserves following? Eur Polym J  2015,65,82-97","journal-title":"Eur Polym J"},{"key":"ref=96","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.7150\/thno.4847","volume":"2","author":"Leung S.J.","year":"2012","unstructured":"Leung S.J.; Romanowski M.; Light-activated content release from liposomes. Theranostics  2012,2(10),1020-1036","journal-title":"Theranostics"},{"key":"ref=97","doi-asserted-by":"publisher","first-page":"636","DOI":"10.3390\/pharmaceutics12070636","volume":"12","author":"Iglesias N.","year":"2020","unstructured":"Iglesias N.; Galbis E.; Romero-Azogil L.; Benito E.; Lucas R.; Garc\u00eda-Mart\u00edn M.G.; de-Paz M.V.; In-depth study into polymeric materials in low-density gastroretentive formulations. Pharmaceutics  2020,12(7),636","journal-title":"Pharmaceutics"},{"key":"ref=98","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/membranes10030052","volume":"10","author":"Mathaba M.","year":"2020","unstructured":"Mathaba M.; Daramola M.O.; Effect of chitosan\u2019s degree of deacetylation on the performance of pes membrane infused with chitosan during amd treatment. Membranes  2020,10(3),52","journal-title":"Membranes"},{"key":"ref=99","first-page":"1058","volume":"14","author":"Olaru N.","year":"2005","unstructured":"Olaru N.; Olaru L.; Phthaloylation of cellulose acetate in acetic acid and acetone Media. Iran Polym J  2005,14(12),1058-1065","journal-title":"Iran Polym J"},{"key":"ref=100","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1002\/macp.201000773","volume":"212","author":"Okayasu T.","year":"2011","unstructured":"Okayasu T.; Hibino T.; Nishide H.; Free radical polymerization kinetics of vinylsulfonic acid and highly acidic properties of its polymer. Macromol Chem Phys  2011,212(10),1072-1079","journal-title":"Macromol Chem Phys"},{"key":"ref=101","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.progpolymsci.2008.05.002","volume":"33","author":"Holmes P.F.","year":"2008","unstructured":"Holmes P.F.; Bohrer M.; Kohn J.; Exploration of polymethacrylate structure\u2013property correlations: Advances towards combinatorial and high-throughput methods for biomaterials discovery. Prog Polym Sci  2008,33(8),787-796","journal-title":"Prog Polym Sci"},{"key":"ref=102","doi-asserted-by":"publisher","first-page":"121298","DOI":"10.1016\/j.carbpol.2023.121298","volume":"321","author":"Pita-Vilar M.","year":"2023","unstructured":"Pita-Vilar M.; Concheiro A.; Alvarez-Lorenzo C.; Diaz-Gomez L.; Recent advances in 3D printed cellulose-based wound dressings: A review on in vitro and in vivo achievements. Carbohydr Polym  2023,321,121298","journal-title":"Carbohydr Polym"},{"key":"ref=103","doi-asserted-by":"publisher","first-page":"31203","DOI":"10.1021\/acsomega.1c04856","volume":"6","author":"Y\u00e1\u00f1ez-Fern\u00e1ndez J.","year":"2021","unstructured":"Y\u00e1\u00f1ez-Fern\u00e1ndez J.; Herrera Ovando M.G.; Patl\u00e1n Ram\u00edrez L.; Ram\u00edrez-Sotelo G.; Guarin C.A.; Castro-Rodr\u00edguez D.C.; Factorial design to optimize dextran production by the native strain Leuconostoc mesenteroides SF3. ACS Omega  2021,6(46),31203-31210","journal-title":"ACS Omega"},{"key":"ref=104","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/1475-2859-10-99","volume":"10","author":"Liu L.","year":"2011","unstructured":"Liu L.; Liu Y.; Li J.; Du G.; Chen J.; Microbial production of hyaluronic acid: Current state, challenges, and perspectives. Microb Cell Fact  2011,10(1),99","journal-title":"Microb Cell Fact"},{"key":"ref=105","doi-asserted-by":"publisher","first-page":"2840","DOI":"10.3390\/polym13172840","volume":"13","author":"Jurko L.","year":"2021","unstructured":"Jurko L.; Bra\u010di\u010d M.; Hribernik S.; Makuc D.; Plavec J.; Jerenec F.; \u017dabkar S.; Gubeljak N.; \u0160tern A.; Kargl R.; Succinylation of polyallylamine: Influence on biological efficacy and the formation of electrospun fibers. Polymers  2021,13(17),2840","journal-title":"Polymers"},{"key":"ref=106","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.polymer.2016.10.015","volume":"105","author":"Vojkovsky T.","year":"2016","unstructured":"Vojkovsky T.; Sullivan B.; Sill K.N.; Synthesis of heterobifunctional polyethylene glycols: Polymerization from functional initiators. Polymer  2016,105,72-78","journal-title":"Polymer"},{"key":"ref=107","doi-asserted-by":"publisher","first-page":"779","DOI":"10.3390\/polym3020779","volume":"3","author":"Bonacucina G.","year":"2011","unstructured":"Bonacucina G.; Cespi M.; Mencarelli G.; Giorgioni G.; Palmieri G.F.; Thermosensitive self-assembling block copolymers as drug delivery systems. Polymers  2011,3(2),779-811","journal-title":"Polymers"},{"key":"ref=108","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3390\/polym12020389","volume":"12","author":"Yang L.","year":"2020","unstructured":"Yang L.; Fan X.; Zhang J.; Ju J.; Preparation and characterization of thermoresponsive poly (N-isopropylacrylamide) for cell culture applications. Polymers  2020,12(2),389","journal-title":"Polymers"},{"key":"ref=109","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.ijpharm.2014.03.038","volume":"466","author":"Osma\u0142ek T.","year":"2014","unstructured":"Osma\u0142ek T.; Froelich A.; Tasarek S.; Application of gellan gum in pharmacy and medicine. Int J Pharm  2014,466(1-2),328-340","journal-title":"Int J Pharm"},{"key":"ref=110","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3390\/pharmaceutics15020402","volume":"15","author":"Jadav M.","year":"2023","unstructured":"Jadav M.; Pooja D.; Adams D.J.; Kulhari H.; Advances in xanthan gum-based systems for the delivery of therapeutic agents. Pharmaceutics  2023,15(2),402","journal-title":"Pharmaceutics"},{"key":"ref=111","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3390\/md19050264","volume":"19","author":"Zhang H.","year":"2021","unstructured":"Zhang H.; Cheng J.; Ao Q.; Preparation of alginate-based biomaterials and their applications in biomedicine. Mar Drugs  2021,19(5),264","journal-title":"Mar Drugs"},{"key":"ref=112","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2174\/2212711906666190723142057","volume":"6","author":"Guha A.","year":"2020","unstructured":"Guha A.; Shaharyar M.A.; Ali K.A.; Roy S.K.; Kuotsu K.; Smart and intelligent stimuli responsive materials: An innovative step in drug delivery system. Curr Biochem Eng  2020,6(1),41-52","journal-title":"Curr Biochem Eng"},{"key":"ref=113","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1186\/s13287-022-02977-y","volume":"13","author":"Silva I.B.B.","year":"2022","unstructured":"Silva I.B.B.; Kimura C.H.; Colantoni V.P.; Sogayar M.C.; Stem cells differentiation into insulin-producing cells (IPCs): Recent advances and current challenges. Stem Cell Res Ther  2022,13(1),309","journal-title":"Stem Cell Res Ther"},{"key":"ref=114","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.3390\/biomedicines10092085","volume":"10","author":"Hsieh M.C.W.","year":"2022","unstructured":"Hsieh M.C.W.; Wang W.T.; Lin C.Y.; Kuo Y.R.; Lee S.S.; Hou M.F.; Wu Y.C.; Stem cell-based therapeutic strategies in diabetic wound healing. Biomedicines  2022,10(9),2085","journal-title":"Biomedicines"},{"key":"ref=115","doi-asserted-by":"publisher","first-page":"869514","DOI":"10.3389\/fimmu.2022.869514","volume":"13","author":"Du S.","year":"2022","unstructured":"Du S.; Li Y.; Geng Z.; Zhang Q.; Buhler L.H.; Gonelle-Gispert C.; Wang Y.; Engineering islets from stem cells: The optimal solution for the treatment of diabetes? Front Immunol  2022,13,869514","journal-title":"Front Immunol"},{"key":"ref=116","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3390\/biology12060871","volume":"12","author":"Rahmadanthi F.R.","year":"2023","unstructured":"Rahmadanthi F.R.; Maksum I.P.; Transfer RNA mutation associated with type 2 diabetes mellitus. Biology  2023,12(6),871","journal-title":"Biology"},{"key":"ref=117","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41419-023-05906-w","volume":"14","author":"Urizar A.I.","year":"2023","unstructured":"Urizar A.I.; Prause M.; Ingerslev L.R.; Wortham M.; Sui Y.; Sander M.; Williams K.; Barr\u00e8s R.; Larsen M.R.; Christensen G.L.; Billestrup N.; Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding. Cell Death Dis  2023,14(7),399","journal-title":"Cell Death Dis"},{"key":"ref=118","doi-asserted-by":"publisher","first-page":"1153805","DOI":"10.3389\/fmed.2023.1153805","volume":"10","author":"Sun H.","year":"2023","unstructured":"Sun H.; Sun R.; Hua Y.; Lu Q.; Shao X.; An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review. Front Med  2023,10,1153805","journal-title":"Front Med"},{"key":"ref=119","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.eprac.2023.04.007","volume":"29","author":"Zahid M.","year":"2023","unstructured":"Zahid M.; Dowlatshahi S.; Kansara A.H.; Sadhu A.R.; The evolution of diabetes technology \u2013 Options toward personalized care. Endocr Pract  2023,29(8),653-662","journal-title":"Endocr Pract"},{"key":"ref=120","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.2174\/0113852728305580240429100851","volume":"28","author":"Seth A.K.","year":"2024","unstructured":"Seth A.K.; Parmar G.; Aundhia C.; Shah N.; Gohil D.; Smart polymer systems: A futuristic approach to enhance therapeutic efficacy. Curr Org Chem  2024,28(15),1164-1178","journal-title":"Curr Org Chem"},{"key":"ref=121","doi-asserted-by":"publisher","first-page":"100253","DOI":"10.1016\/j.medntd.2023.100253","volume":"19","author":"Karmakar S.","year":"2023","unstructured":"Karmakar S.; Bhowmik M.; Laha B.; Manna S.; Recent advancements on novel approaches of insulin delivery. Med Novel Technol Devices  2023,19,100253","journal-title":"Med Novel Technol Devices"},{"key":"ref=122","doi-asserted-by":"publisher","first-page":"7855","DOI":"10.1021\/cr200027j","volume":"111","author":"Wu Q.","year":"2011","unstructured":"Wu Q.; Wang L.; Yu H.; Wang J.; Chen Z.; Organization of glucose-responsive systems and their properties. Chem Rev  2011,111(12),7855-7875","journal-title":"Chem Rev"},{"key":"ref=123","doi-asserted-by":"publisher","first-page":"206","DOI":"10.2174\/1872211307666131118141600","volume":"7","author":"Patel G.","year":"2013","unstructured":"Patel G.; Dalwadi C.; Recent patents on stimuli responsive hydrogel drug delivery system. Recent Pat Drug Deliv Formul  2013,7(3),206-215","journal-title":"Recent Pat Drug Deliv Formul"},{"key":"ref=124","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3389\/fbioe.2020.00880","volume":"8","author":"Zhao R.","year":"2020","unstructured":"Zhao R.; Lu Z.; Yang J.; Zhang L.; Li Y.; Zhang X.; Drug delivery system in the treatment of diabetes mellitus. Front Bioeng Biotechnol  2020,8,880","journal-title":"Front Bioeng Biotechnol"},{"key":"ref=125","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/btm2.10036","volume":"1","author":"Yu J.","year":"2016","unstructured":"Yu J.; Zhang Y.; Bomba H.; Gu Z.; Stimuli\u2010responsive delivery of therapeutics for diabetes treatment. Bioeng Transl Med  2016,1(3),323-337","journal-title":"Bioeng Transl Med"},{"key":"ref=126","author":"Akashi M.","year":"2009","unstructured":"Akashi M.; Sawa Y.; Matsusaki M.; Stimuli-responsive degradable gel.  2009"},{"key":"ref=127","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1517\/17425247.5.10.1077","volume":"5","author":"Bikram M.","year":"2008","unstructured":"Bikram M.; West J.L.; Thermo-responsive systems for controlled drug delivery. Expert Opin Drug Deliv  2008,5(10),1077-1091","journal-title":"Expert Opin Drug Deliv"},{"key":"ref=128","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.bioactmat.2022.02.008","volume":"18","author":"Wang L.","year":"2022","unstructured":"Wang L.; Li Y.; Ren M.; Wang X.; Li L.; Liu F.; Lan Y.; Yang S.; Song J.; pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats. Bioact Mater  2022,18,254-266","journal-title":"Bioact Mater"},{"key":"ref=129","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1163\/156856207781367701","volume":"18","author":"Namkung S.","year":"2007","unstructured":"Namkung S.; Chu C.C.; Partially biodegradable temperature- and pH-responsive poly(N-isopropylacrylamide)\/dextran-maleic acid hydrogels: formulation and controlled drug delivery of doxorubicin. J Biomater Sci Polym Ed  2007,18(7),901-924","journal-title":"J Biomater Sci Polym Ed"},{"key":"ref=130","author":"Lee D.S.","year":"2016","unstructured":"Lee D.S.; Nguyen M.K.; Kim B.S.; Temperature and pH-sensitive block copolymer having excellent safty in vivo and hydrogel and drug delivery system using thereof.  2016"},{"key":"ref=131","author":"Alexander L.Y.","year":"2010","unstructured":"Alexander L.Y.; Stimuli responsive low solubility hydrogel co polymers of N isopropyl acrylamide and synthesis method patent.  2010"},{"key":"ref=132","author":"Han D.K.","year":"2010","unstructured":"Han D.K.; Park K.; Kim J.J.; Thermosensitive pluronic derivative hydrogels with high biodegradability and biocompatibility for tissue regeneration and preparation method thereof.  2010"},{"key":"ref=133","doi-asserted-by":"publisher","first-page":"109230","DOI":"10.1016\/j.matdes.2020.109230","volume":"197","author":"Weng C.C.","year":"2021","unstructured":"Weng C.C.; Yang T.A.; Li Y.K.; Design and fabrication of cell-targeted, dual drug-loaded nanoparticles with pH-controlled drug release and near-infrared light-induced photothermal effects. Mater Des  2021,197,109230","journal-title":"Mater Des"},{"key":"ref=134","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1007\/s00125-021-05422-6","volume":"64","author":"Jarosinski M.A.","year":"2021","unstructured":"Jarosinski M.A.; Dhayalan B.; Rege N.; Chatterjee D.; Weiss M.A.; \u2018Smart\u2019 insulin-delivery technologies and intrinsic glucose-responsive insulin analogues. Diabetologia  2021,64(5),1016-1029","journal-title":"Diabetologia"}],"container-title":["Current Drug Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113892002390554251015114414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/247247\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113892002390554251015114414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:04:01Z","timestamp":1772085841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/247247\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":134,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0113892002390554251015114414","relation":{},"ISSN":["1389-2002"],"issn-type":[{"value":"1389-2002","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2025-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}