{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:04:55Z","timestamp":1781305495865,"version":"3.54.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"13","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Fungal infections contribute to over 1.5 million fatalities each year, with cutaneous\nmycoses standing as prominent global infections. The spectrum of these mycoses varies widely,\nencompassing enduring afflictions like ringworm, localized infections such as tinea capitis, recurrent\ninstances like vaginal candidiasis, and potentially fatal systemic infections impacting\nmultiple organ systems. The escalating recognition of the health and socioeconomic ramifications\nassociated with fungal pathogens underscores their importance in contemporary discourse.\nOn a global scale, projections indicate that over 300 million individuals experience significant\nfungal infections annually, resulting in a mortality rate exceeding 1.5 million deaths per year.\nAlarmingly, resistance to commonly used antifungal drugs was on the rise, with some reports\nsuggesting that over 10% of Candida bloodstream isolates worldwide were resistant to fluconazole,\na commonly prescribed antifungal medication. Therefore, there is an immediate need to\nincrease the accessibility of new antifungal medications while minimizing their costs and adverse\neffects. Fungi, as heterotrophic organisms, acquire nutrients through absorption. Their\nfilamentous structure, composed of hyphae, facilitates efficient nutrient uptake by secreting enzymes\nthat break down complex organic matter into simpler compounds. These organisms exhibit\nremarkable adaptability in responding to environmental cues, adjusting growth rates, and\naltering morphological features. Fungi regulate their metabolism intricately, undergoing various\nmetabolic pathways for energy production and utilizing diverse substrates for respiration. Additionally,\nthey exhibit distinctive reproductive strategies, employing both sexual and asexual\nmodes of reproduction, contributing to their genetic diversity and resilience in diverse ecosystems.\nWe now have more information than ever on the origins of infection as well as the physiology\nof fungi cells, giving us the chance to use it to produce new generations of antifungals.\nThis review includes various novel antifungal drug targets showing their possible effects via\ndifferent mechanisms aiming at vital functions like GPI synthesis, cell wall synthesis, hyphal\ngrowth, and other essential pathways responsible for fungal growth.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0113892010304880240828075411","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T05:13:08Z","timestamp":1726463588000},"page":"2097-2110","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Arsenal of Novel Antifungal Drug Targets for Combating Fungal Infections"],"prefix":"10.2174","volume":"26","author":[{"given":"Pooja","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Parul Institute of Pharmacy, Parul University, Limda, Waghodia, Vadodara, Gujarat,\nIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3604-477X","authenticated-orcid":true,"given":"Archana","family":"Navale","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Parul Institute of Pharmacy, Parul University, Limda, Waghodia, Vadodara, Gujarat,\nIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-7473","authenticated-orcid":true,"given":"Ajay","family":"Shelke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Parul Institute of Pharmacy, Parul University, Limda, Waghodia, Vadodara, Gujarat,\nIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4871-5358","authenticated-orcid":true,"given":"Muskan","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Parul Institute of Pharmacy, Parul University, Limda, Waghodia, Vadodara, Gujarat,\nIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Pharmaceutical Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113892010304880240828075411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/234038\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113892010304880240828075411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:30:35Z","timestamp":1758785435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/234038\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":0,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0113892010304880240828075411","relation":{},"ISSN":["1389-2010"],"issn-type":[{"value":"1389-2010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2024-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-06","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}