{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:10:37Z","timestamp":1745467837603,"version":"3.40.4"},"reference-count":50,"publisher":"Bentham Science Publishers Ltd.","issue":"6","funder":[{"DOI":"10.13039\/501100012155","name":"National Institutes for Medical Research Development (NIMAD), Tehran, Iran","doi-asserted-by":"publisher","award":["996656"],"award-info":[{"award-number":["996656"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Organophosphorus insecticides, widely used in farming and agriculture,\nhave been associated with various health issues. Curcumin, a natural antioxidant, has\nshown potential in mitigating the adverse effects induced by these insecticides.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Aim:<\/jats:title>\n<jats:p>This study aimed to evaluate the nephroprotective effects of Curcumin (CUR) against\nChlorpyrifos (CPF)-induced renal damage.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Forty male Wistar albino rats were randomly assigned to five groups, each containing\neight rats: control (0.5 mL of olive oil, the solvent for chlorpyrifos), CPF (10 mg\/kg of chlorpyrifos),\nCPF + CUR 25 mg\/kg\/day, CPF + CUR 50 mg\/kg\/day, and CPF + CUR 100 mg\/k\/day. All\ngroups were treated for 90 days. Finally, kidney tissue was assessed for oxidative stress, inflammatory\nmarkers, and histopathological changes.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Result:<\/jats:title>\n<jats:p>A considerable elevation in urea and Creatinine (Cr) concentrations was observed in the\nCPF group compared to the control rats (p &lt; 0.01). CUR decreased creatinine and urea levels in\nthe CPF-exposed group compared to the non-CUR-treated animals (p &lt; 0.05). Additionally, the\nconcentrations of NO, MDA, IL-6, IL-1\u03b2, and TNF\u03b1 were significantly increased in the kidneys\nof the CPF-induced rats compared to the controls (p &lt; 0.001). However, CUR (100 mg\/kg) administration\nsignificantly reduced the abovementioned parameters in rat kidneys (p &lt; 0.01). CUR\n(100 mg\/kg) also increased superoxide dismutase activity and glutathione concentration in the\nkidneys of CPF-exposed animals compared to non-CUR-treated rats (p &lt; 0.05). Histopathological\nanalysis revealed severe congestion in the kidney tissue after CPF exposure. However, coadministration\nof CUR restored the normal structure of the kidney in the experimental rats.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our findings suggest that curcumin, a potent antioxidant, can help alleviate\nchlorpyrifos-induced nephrotoxicity.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0113892010307571240817190846","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T07:22:37Z","timestamp":1725607357000},"page":"827-835","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of Curcumin against Nephrotoxicity in Male Rats after Chronic Exposure to Chlorpyrifos"],"prefix":"10.2174","volume":"26","author":[{"given":"Tahereh","family":"Farkhondeh","sequence":"first","affiliation":[{"name":"Geriatric Health Research Center, Birjand University of Medical Sciences, Birjand, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Roshanravan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics,\nSchool of Medicine, Shafa Yahyaeian Orthopedics Hospital, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariborz","family":"Samini","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Samarghandian","sequence":"additional","affiliation":[{"name":"Department of Medical\nPhysiology, Neyshabur University of Medical Sciences, Neyshabur, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.2174\/1871529X16666160802144510","volume":"16","author":"Farkhondeh T.","year":"2016","unstructured":"Farkhondeh T.; Samarghandian S.; Antidotal Effects of Curcumin Against Agents-Induced Cardiovascular Toxicity. Cardiovasc Hematol Disord Drug Targets  2016,16(1),30-37","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.msec.2017.03.226","volume":"77","author":"Hussain Z.","year":"2017","unstructured":"Hussain Z.; Thu H.E.; Amjad M.W.; Hussain F.; Ahmed T.A.; Khan S.; Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives. Mater Sci Eng C  2017,77,1316-1326","journal-title":"Mater Sci Eng C"},{"key":"ref=3","first-page":"2465","volume":"8","year":"2015","unstructured":"Farkhondeh T, Samarghandian S, Azimin-Nezhad M, Samini F. Effect of chrysin on nociception in formalin test and serum levels of noradrenalin and corticosterone in rats. Int J Clin Exp Med  2015,8(2),2465","journal-title":"Int J Clin Exp Med"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"21243","DOI":"10.1074\/jbc.RA117.000123","volume":"292","author":"Edwards R.L.","year":"2017","unstructured":"Edwards R.L.; Luis P.B.; Varuzza P.V.; Joseph A.I.; Presley S.H.; Chaturvedi R.; Schneider C.; The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites. J Biol Chem  2017,292(52),21243-21252","journal-title":"J Biol Chem"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"6489","DOI":"10.1002\/ptr.7224","volume":"35","author":"Razavi B.M.","year":"2021","unstructured":"Razavi B.M.; Ghasemzadeh Rahbardar M.; Hosseinzadeh H.; A review of therapeutic potentials of turmeric ( ) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents. Phytother Res  2021,35(12),6489-6513","journal-title":"Phytother Res"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"4374","DOI":"10.2174\/0929867330666230112092802","volume":"30","author":"Jafari-Nozad A.M.","year":"2023","unstructured":"Jafari-Nozad A.M.; Jafari A.; Zangooie A.; Behdadfard M.; Zangouei A.S.; Aschner M.; Farkhondeh T.; Samarghandian S.; Curcumin Combats against Gastrointestinal Cancer: A Review of Current Knowledge Regarding Epigenetics Mechanisms with a Focus on DNA Methylation. Curr Med Chem  2023,30(38),4374-4388","journal-title":"Curr Med Chem"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1002\/ptr.6323","volume":"33","author":"Azhdari M.","year":"2019","unstructured":"Azhdari M.; Karandish M.; Mansoori A.; Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta\u2010analysis of randomized controlled trials. Phytother Res  2019,33(5),1289-1301","journal-title":"Phytother Res"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.3390\/nu11081837","volume":"11","author":"Pivari F.","year":"2019","unstructured":"Pivari F.; Mingione A.; Brasacchio C.; Soldati L.; Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment. Nutrients  2019,11(8),1837","journal-title":"Nutrients"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13813455.2019.1671458","volume":"14","year":"2014","unstructured":"Samarghandian S, Hadjzadeh MA, Afshari JT, Hosseini M. Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line. BMC Complement Altern Med  2014,14,1-9","journal-title":"BMC Complement Altern Med"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"18893","DOI":"10.1007\/s11356-021-12809-w","volume":"28","author":"Grover M.","year":"2021","unstructured":"Grover M.; Behl T.; Sachdeva M.; Bungao S.; Aleya L.; Setia D.; Focus on Multi-targeted Role of Curcumin: A Boon in Therapeutic Paradigm. Environ Sci Pollut Res Int  2021,28(15),18893-18907","journal-title":"Environ Sci Pollut Res Int"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.apjtm.2017.08.020","volume":"10","author":"Farkhondeh T.","year":"2017","unstructured":"Farkhondeh T.; Samarghandian S.; Borji A.; An overview on cardioprotective and anti-diabetic effects of thymoquinone. Asian Pac J Trop Med  2017,10(9),849-854","journal-title":"Asian Pac J Trop Med"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1007\/s11356-016-7912-6","volume":"24","author":"Alaa-Eldin E.A.","year":"2017","unstructured":"Alaa-Eldin E.A.; El-Shafei D.A.; Abouhashem N.S.; Individual and combined effect of chlorpyrifos and cypermethrin on reproductive system of adult male albino rats. Environ Sci Pollut Res Int  2017,24(2),1532-1543","journal-title":"Environ Sci Pollut Res Int"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"117010","DOI":"10.1016\/j.envpol.2021.117010","volume":"282","author":"Zhao L.","year":"2021","unstructured":"Zhao L.; Tang G.; Xiong C.; Han S.; Yang C.; He K.; Liu Q.; Luo J.; Luo W.; Wang Y.; Li Z.; Yang S.; Chronic chlorpyrifos exposure induces oxidative stress, apoptosis and immune dysfunction in largemouth bass (Micropterus salmoides). Environ Pollut  2021,282,117010","journal-title":"Environ Pollut"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.scitotenv.2016.06.014","volume":"568","author":"Sumon K.A.","year":"2016","unstructured":"Sumon K.A.; Rico A.; Ter Horst M.M.S.; Van den Brink P.J.; Haque M.M.; Rashid H.; Risk assessment of pesticides used in rice-prawn concurrent systems in Bangladesh. Sci Total Environ  2016,568,498-506","journal-title":"Sci Total Environ"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.chemosphere.2019.05.020","volume":"229","author":"Li J.","year":"2019","unstructured":"Li J.; Pang G.; Ren F.; Fang B.; Chlorpyrifos-induced reproductive toxicity in rats could be partly relieved under high-fat diet. Chemosphere  2019,229,94-102","journal-title":"Chemosphere"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3390\/biom9070261","volume":"9","author":"Albasher G.","year":"2019","unstructured":"Albasher G.; Almeer R.; Al-Otibi F.O.; Al-Kubaisi N.; Mahmoud A.M.; Ameliorative Effect of Beta vulgaris Root Extract on Chlorpyrifos-Induced Oxidative Stress, Inflammation and Liver Injury in Rats. Biomolecules  2019,9(7),261","journal-title":"Biomolecules"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s11274-011-0879-z","volume":"28","author":"Sasikala C.","year":"2012","unstructured":"Sasikala C.; Jiwal S.; Rout P.; Ramya M.; Biodegradation of chlorpyrifos by bacterial consortium isolated from agriculture soil. World J Microbiol Biotechnol  2012,28(3),1301-1308","journal-title":"World J Microbiol Biotechnol"},{"key":"ref=18","doi-asserted-by":"crossref","first-page":"S419","DOI":"10.4103\/0973-1296.133296","volume":"10","year":"2014","unstructured":"Samarghandian S, Shoshtari ME, Sargolzaei J, Hossinimoghadam H, Farahzad JA. Anti-tumor activity of safranal against neuroblastoma cells. Pharmacogn Magaz  2014,10(Suppl 2),S419","journal-title":"Pharmacogn Magaz"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"151621","DOI":"10.1016\/j.acthis.2020.151621","volume":"122","author":"Eronat K.","year":"2020","unstructured":"Eronat K.; Sa\u011f\u0131r D.; Protective effects of curcumin and Ganoderma lucidum on hippocampal damage caused by the organophosphate insecticide chlorpyrifos in the developing rat brain: Stereological, histopathological and immunohistochemical study. Acta Histochem  2020,122(7),151621","journal-title":"Acta Histochem"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.fct.2013.01.056","volume":"55","author":"Uzun F.G.","year":"2013","unstructured":"Uzun F.G.; Kalender Y.; Chlorpyrifos induced hepatotoxic and hematologic changes in rats: The role of quercetin and catechin. Food Chem Toxicol  2013,55,549-556","journal-title":"Food Chem Toxicol"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.pestbp.2009.08.008","volume":"96","author":"Mansour S.A.","year":"2010","unstructured":"Mansour S.A.; Mossa A.T.H.; Oxidative damage, biochemical and histopathological alterations in rats exposed to chlorpyrifos and the antioxidant role of zinc. Pestic Biochem Physiol  2010,96(1),14-23","journal-title":"Pestic Biochem Physiol"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1002\/tox.23850","volume":"38","author":"Hsu S.S.","year":"2023","unstructured":"Hsu S.S.; Lin Y.S.; Chen H.C.; Liang W.Z.; Involvement of oxidative stress\u2010related apoptosis in chlorpyrifos\u2010induced cytotoxicity and the ameliorating potential of the antioxidant vitamin E in human glioblastoma cells. Environ Toxicol  2023,38(9),2143-2154","journal-title":"Environ Toxicol"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/tox.23451","volume":"37","author":"Alipanah H.","year":"2022","unstructured":"Alipanah H.; Kabi Doraghi H.; Sayadi M.; Nematollahi A.; Soltani Hekmat A.; Nejati R.; Subacute toxicity of chlorpyrifos on histopathological damages, antioxidant activity, and pro\u2010inflammatory cytokines in the rat model. Environ Toxicol  2022,37(4),880-888","journal-title":"Environ Toxicol"},{"key":"ref=24","first-page":"195","volume":"65","author":"Verma R.J.","year":"2008","unstructured":"Verma R.J.; Mathuria N.; Curcumin ameliorates aflatoxin-induced lipid-peroxidation in liver and kidney of mice. Acta Pol Pharm  2008,65(2),195-202","journal-title":"Acta Pol Pharm"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1002\/jcp.29327","volume":"235","author":"Ashrafizadeh M.","year":"2020","unstructured":"Ashrafizadeh M.; Ahmadi Z.; Farkhondeh T.; Samarghandian S.; Resveratrol targeting the Wnt signaling pathway: A focus on therapeutic activities. J Cell Physiol  2020,235(5),4135-4145","journal-title":"J Cell Physiol"},{"key":"ref=26","first-page":"37","volume":"7","author":"Ambali S.F.","year":"2010","unstructured":"Ambali S.F.; Akanbi D.O.; Shittu M.; Giwa A.; Oladipo O.O.; Ayo J.O.; Chlorpyrifos-induced clinical, haematological and biochemical changes in Swiss albino mice: Mitigating effect by co-administration of vitamins C and E. Life Sci J  2010,7(3),37-44","journal-title":"Life Sci J"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.3390\/molecules23123283","volume":"23","author":"Pohl F.","year":"2018","unstructured":"Pohl F.; Kong Thoo Lin P.; The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention\/Treatment of Neurodegenerative Diseases: In vitro, In vivo and Clinical Trials. Molecules  2018,23(12),3283","journal-title":"Molecules"},{"key":"ref=28a","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1002\/jcb.29392","volume":"121","author":"Ashrafizadeh M.","year":"2020","unstructured":"Ashrafizadeh M.; Fekri H.S.; Ahmadi Z.; Farkhondeh T.; Samarghandian S.; Therapeutic and biological activities of berberine: The involvement of Nrf2 signaling pathway. J Cell Biochem  2020,121(2),1575-1585","journal-title":"J Cell Biochem"},{"key":"ref=28b","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.humpath.2022.03.003","volume":"124","year":"2022","unstructured":"Jia Y, Poor SMM, Dufault B, Lu V, Nayak JG, Pruthi DK, Gibson IW. Chronic kidney damage pathology score for systematic assessment of the non-neoplastic kidney tissue and prediction of postoperative renal function outcomes. Hum Pathol  2022,124,76-84","journal-title":"Hum Pathol"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1158\/1078-0432.162.11.1","volume":"11","author":"Bhatia P.","year":"2005","unstructured":"Bhatia P.; Sanders M.M.; Hansen M.F.; Expression of receptor activator of nuclear factor-kappaB is inversely correlated with metastatic phenotype in breast carcinoma. Clin Cancer Res  2005,11(1),162-165","journal-title":"Clin Cancer Res"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"13539","DOI":"10.1007\/s11356-019-04935-3","volume":"26","author":"Al-Brakati A.Y.","year":"2019","unstructured":"Al-Brakati A.Y.; Fouda M.S.; Tharwat A.M.; Elmahallawy E.K.; Kassab R.B.; Abdel Moneim A.E.; The protective efficacy of soursop fruit extract against hepatic injury associated with acetaminophen exposure is mediated through antioxidant, anti-inflammatory, and anti-apoptotic activities. Environ Sci Pollut Res Int  2019,26(13),13539-13550","journal-title":"Environ Sci Pollut Res Int"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.etap.2018.10.010","volume":"64","author":"Salyha N.","year":"2018","unstructured":"Salyha N.; Salyha Y.; Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats. Environ Toxicol Pharmacol  2018,64,155-163","journal-title":"Environ Toxicol Pharmacol"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"104959","DOI":"10.1016\/j.pestbp.2021.104959","volume":"179","author":"Abd-Elhakim Y.M.","year":"2021","unstructured":"Abd-Elhakim Y.M.; Moustafa G.G.; El-Sharkawy N.I.; Hussein M.M.A.; Ghoneim M.H.; El Deib M.M.; The ameliorative effect of curcumin on hepatic CYP1A1 and CYP1A2 genes dysregulation and hepatorenal damage induced by fenitrothion oral intoxication in male rats. Pestic Biochem Physiol  2021,179,104959","journal-title":"Pestic Biochem Physiol"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/3595761","volume":"2019","author":"Albasher G.","year":"2019","unstructured":"Albasher G.; Almeer R.; Alarifi S.; Alkhtani S.; Farhood M.; Al-Otibi F.O.; Alkubaisi N.; Rizwana H.; Nephroprotective Role of Beta vulgaris L. Root Extract against Chlorpyrifos-Induced Renal Injury in Rats. Evid Based Complement Alternat Med  2019,2019,1-9","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.toxrep.2019.02.007","volume":"6","author":"Owumi S.E.","year":"2019","unstructured":"Owumi S.E.; Dim U.J.; Manganese suppresses oxidative stress, inflammation and caspase-3 activation in rats exposed to chlorpyrifos. Toxicol Rep  2019,6,202-209","journal-title":"Toxicol Rep"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1007\/s11356-015-5448-9","volume":"23","author":"Nasr H.M.","year":"2016","unstructured":"Nasr H.M.; El-Demerdash F.M.; El-Nagar W.A.; Neuro and renal toxicity induced by chlorpyrifos and abamectin in rats. Environ Sci Pollut Res Int  2016,23(2),1852-1859","journal-title":"Environ Sci Pollut Res Int"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/toxics9060137","volume":"9","author":"Ismail A.A.","year":"2021","unstructured":"Ismail A.A.; Hendy O.; Abdel Rasoul G.; Olson J.R.; Bonner M.R.; Rohlman D.S.; Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents. Toxics  2021,9(6),137","journal-title":"Toxics"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1080\/19338244.2017.1317627","volume":"73","author":"Saoudi M.","year":"2018","unstructured":"Saoudi M.; Hmida I.B.; Kammoun W.; Rebah F.B.; Jamoussi K.; Feki A.E.; Protective effects of oil of Sardinella pilchardis against subacute chlorpyrifos-induced oxidative stress in female rats. Arch Environ Occup Health  2018,73(2),128-135","journal-title":"Arch Environ Occup Health"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"512","DOI":"10.3906\/sag-1403-109","volume":"46","author":"Baba N.","year":"2016","unstructured":"Baba N.; Raina R.; Verma P.; Sultana M.; Free radical-induced nephrotoxicity following repeated oral exposureto chlorpyrifos alone and in conjunction with fluoride in rats. Turk J Med Sci  2016,46(2),512-517","journal-title":"Turk J Med Sci"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1177\/0960327118818246","volume":"38","author":"Al-Brakati A.Y.","year":"2019","unstructured":"Al-Brakati A.Y.; Kassab R.B.; Lokman M.S.; Elmahallawy E.K.; Amin H.K.; Abdel Moneim A.E.; Role of thymoquinone and ebselen in the prevention of sodium arsenite\u2013induced nephrotoxicity in female rats. Hum Exp Toxicol  2019,38(4),482-493","journal-title":"Hum Exp Toxicol"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"560","DOI":"10.2174\/1389200216666151015114515","volume":"16","author":"Homma T.","year":"2015","unstructured":"Homma T.; Fujii J.; Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs. Curr Drug Metab  2015,16(7),560-571","journal-title":"Curr Drug Metab"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"12072","DOI":"10.1007\/s11356-018-1391-x","volume":"25","author":"El-Sayed N.M.","year":"2018","unstructured":"El-Sayed N.M.; Ahmed A.A.M.; Selim M.A.A.; Cytotoxic effect of chlorpyrifos is associated with activation of Nrf-2\/HO-1 system and inflammatory response in tongue of male Wistar rats. Environ Sci Pollut Res Int  2018,25(12),12072-12082","journal-title":"Environ Sci Pollut Res Int"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1002\/ptr.5638","volume":"30","author":"Samarghandian S.","year":"2016","unstructured":"Samarghandian S.; Azimi-Nezhad M.; Borji A.; Farkhondeh T.; Effect of crocin on aged rat kidney through inhibition of oxidative stress and proinflammatory state. Phytother Res  2016,30(8),1345-1353","journal-title":"Phytother Res"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s11011-018-0341-0","volume":"34","author":"Kassab R.B.","year":"2019","unstructured":"Kassab R.B.; Lokman M.S.; Essawy E.A.; Neurochemical alterations following the exposure to di-n-butyl phthalate in rats. Metab Brain Dis  2019,34(1),235-244","journal-title":"Metab Brain Dis"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.3390\/antiox9111092","volume":"9","author":"Jakubczyk K.","year":"2020","unstructured":"Jakubczyk K.; Dru\u017cga A.; Katarzyna J.; Skonieczna-\u017bydecka K.; Antioxidant Potential of Curcumin\u2014A Meta-Analysis of Randomized Clinical Trials. Antioxidants  2020,9(11),1092","journal-title":"Antioxidants"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2174\/1871529X18666180212114816","volume":"18","author":"Shaterzadeh-Yazdi H.","year":"2018","unstructured":"Shaterzadeh-Yazdi H.; Noorbakhsh M.F.; Hayati F.; Samarghandian S.; Farkhondeh T.; Immunomodulatory and Anti-inflammatory Effects of Thymoquinone. Cardiovasc Hematol Disord Drug Targets  2018,18(1),52-60","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1080\/0886022X.2016.1229996","volume":"38","author":"Topcu-Tarladacalisir Y.","year":"2016","unstructured":"Topcu-Tarladacalisir Y.; Sapmaz-Metin M.; Karaca T.; Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis. Ren Fail  2016,38(10),1741-1748","journal-title":"Ren Fail"},{"key":"ref=47","first-page":"64","volume":"3","author":"Al-Amoudi W.M.","year":"2013","unstructured":"Al-Amoudi W.M.; Curcumin ameliorates nephrotoxicity and histopathological alterations induced by chlorpyrifos in albino rats. J Pharma Res  2013,3(1),64","journal-title":"J Pharma Res"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"790","DOI":"10.3390\/antiox9090790","volume":"9","author":"Chen Y.H.","year":"2020","unstructured":"Chen Y.H.; Chen H.L.; Fan H.C.; Tung Y.T.; Kuo C.W.; Tu M.Y.; Chen C.M.; Anti-Inflammatory, Antioxidant, and Antifibrotic Effects of Kefir Peptides on Salt-Induced Renal Vascular Damage and Dysfunction in Aged Stroke-Prone Spontaneously Hypertensive Rats. Antioxidants  2020,9(9),790","journal-title":"Antioxidants"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1080\/01913123.2022.2152144","volume":"46","author":"\u015eener Ak\u00e7ora D","year":"2022","unstructured":"\u015eener Ak\u00e7ora D; Erdo\u011fan D; Take Kaplano\u011flu G; G\u00f6kta\u015f GE; \u015eeker U; Elmas \u00c7; Electron microscopic investigation of benzo(a)pyrene-induced alterations in the rat kidney tissue and the protective effects of curcumin. Ultrastruct Pathol  2022,46(6),519-530","journal-title":"Ultrastruct Pathol"}],"container-title":["Current Pharmaceutical Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113892010307571240817190846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/233762\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113892010307571240817190846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:05:25Z","timestamp":1745409925000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/233762\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0113892010307571240817190846","relation":{},"ISSN":["1389-2010"],"issn-type":[{"type":"print","value":"1389-2010"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2024-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}