{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:39:53Z","timestamp":1792395593353,"version":"4.4.0"},"reference-count":35,"publisher":"Bentham Science Publishers Ltd.","issue":"10","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Selenium is an important trace element that plays crucial roles in metabolism,\nimmune function, and antioxidant defense. As an antioxidant, selenium helps to alleviate\npostpartum uterine inflammation and promotes uterine recovery. However, the exact mechanism\nunderlying the role of selenium in postpartum uterine recovery is not fully understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to identify the underlying mechanism and examine how selenium\nenhances postpartum uterine healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Female ICR mice aged 8 weeks were classified into five groups: control, postpartum\nmodel, low-dose selenium (100 nm), medium-dose selenium (200 nm), and high-dose selenium\n(400 nm). Endometrial morphology was evaluated by hematoxylin and eosin (H&amp;E) staining.\nOxidative stress markers, including superoxide dismutase (SOD), catalase (CAT), glutathione\nperoxidase (GPX), and malondialdehyde (MDA), and inflammatory factors, including tumor\nnecrosis factor-alpha (TNF-\u03b1) and interleukin-1 beta (IL-1\u03b2), were measured using commercially\navailable kits. GPX1, GPX4, and nuclear factor erythroid 2-related factor 2 (NRF2) expression\nwere determined using real-time PCR and WB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found damage and bleeding points in the endometrium and destruction of the ultrastructure\nof endometrial cells in the postpartum model group; however, mice treated with a high\ndose (400 nm) of selenium showed alleviated levels of pathological alteration in the endometrium.\nIn addition, the levels of MDA in the postpartum mice group increased, while the SOD,\nCAT, and GPX levels decreased; however, changes in these oxidative stress markers were reversed\nafter selenium treatment. For inflammatory factors, high levels of TNF-\u03b1 and IL-1\u03b2 were\nobserved in postpartum mice, whereas they were decreased in selenium-treated groups. GPX1,\nGPX4, and NRF2 expression were reduced in postpartum model mice, but upregulated in selenium-\ntreated mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Selenium supplementation ameliorated postpartum uterine oxidative stress and\ninflammation and promoted uterine recovery via the GPX1\/GPX4\/NRF2 pathway in mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0113892010371042250416035948","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:14:06Z","timestamp":1745565246000},"page":"1181-1188","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selenium Alleviates Oxidative Stress and Inflammation to Promote Postpartum Uterine Recovery via GPX1\/GPX4\/NRF2 Pathway in Mice"],"prefix":"10.2174","volume":"27","author":[{"given":"Xiangping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospitalof Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospitalof Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospitalof Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.3390\/nu15163513","volume":"15","author":"Vicariotto F.","year":"2023","unstructured":"Vicariotto F.; Malfa P.; Torricelli M.; Lungaro L.; Beneficial effects of Limosilactobacillus reuteri PBS072 and Bifidobacterium breve BB077 on mood imbalance, self-confidence, and breastfeeding in women during the first trimester postpartum. 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J Anim Sci Biotechnol  2017,8(1),33","journal-title":"J Anim Sci Biotechnol"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.theriogenology.2008.12.005","volume":"71","author":"Cerri R.","year":"2009","unstructured":"Cerri R.; Rutigliano H.; Lima F.; Effect of source of supplemental selenium on uterine health and embryo quality in high-producing dairy cows. 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