{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:29:48Z","timestamp":1786364988044,"version":"build-2736575974"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2026,7,29]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>Delta hepatitis, caused by the Hepatitis Delta Virus (HDV), is considered a satellite\nvirus as it uses proteins from the hepatitis B virus for its assembly and release. Currently, serological\nand molecular tests are available for the diagnosis of HDV, with limitations such as\nstandardization, for molecular tests, a short detection window in the acute phase, and the formation\nof antigen-antibody complexes during the chronic phase, for serological tests, which can\ncause variability in sensitivity and specificity values. Furthermore, molecular tests are more expensive\nand require specialized infrastructure as compared to serological tests. Due to these\nlimitations, studies focused on the development of diagnostic tests are crucial, and the commercialization\nof these tests would help fill existing gaps in the detection and management of the\ndisease. However, despite the severity of the disease and the limitations of diagnostic tests, publications,\nsuch as articles and patents using serological diagnosis, are scarce. Literature reviews\nare fundamental for disseminating information, describing advances related to the topic and its\ndifficulties, and fostering academic and commercial interest among researchers. Therefore, the\nobjective of this review is to explore patent databases for serological diagnostic technologies for\nHDV infection. The results identified only nine patents related to serological diagnosis. Most of\nthese patents showed promising results, achieving a sensitivity and specificity above 90%. However,\nthe small number of registered patents highlights the need for greater investment and partnerships\nto boost research, validate technologies, and facilitate the commercialization of tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0113892010449084260416100652","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:08:31Z","timestamp":1785438511000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Biotechnological Review of Potential Patents for Serological Diagnosis of Hepatitis Delta Virus"],"prefix":"10.2174","volume":"27","author":[{"given":"Isadora Braga","family":"Gandra","sequence":"first","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Rodrigues","family":"Xavier","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle Caroline dos Santos","family":"Barcelos","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Paula","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Julia","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila Alves","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Alves Petit","family":"Couto","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Ananias Aparecido","family":"Resende","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas da Silva","family":"Lopes","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Lais Nascimento","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassio Siqueira Souza","family":"Cassiano","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia Correa","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Fellype Alves","family":"de Souza","sequence":"additional","affiliation":[{"name":"Charles Merieux Infectious Diseases Center &amp; Rodolphe Merieux Laboratory (FUNDHACRE), Rio Branco, 69917-672, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutilene Barbosa","family":"Souza","sequence":"additional","affiliation":[{"name":"Charles Merieux Infectious Diseases Center &amp; Rodolphe Merieux Laboratory (FUNDHACRE), Rio Branco, 69917-672, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Ma\u00edsa","family":"Passos-Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Virology, Oswaldo Cruz Foundation Rond\u00f4nia, (FIOCRUZ\/RO), Porto Velho, 76812-245, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Martins","family":"Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms Biotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, and National Instituteof Science and Technology in Industrial Biotechnology (INCT-BI), Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Campos da Paz","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Compounds and Nanobiotechnology, Federal University of S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Ch\u00e1vez-Fumagalli","sequence":"additional","affiliation":[{"name":"Computational Biology and Chemistry Research Group, Vice-Rectorate for Research, Catholic University of Santa Mar\u00eda, Arequipa 04000, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Antonio Ferraz","family":"Coelho","sequence":"additional","affiliation":[{"name":"Postgraduate program in Health Sciences: Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG 30130-100, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo Cordeiro","family":"Giunchetti","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Interactions Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Alice 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