{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:44:36Z","timestamp":1791974676868,"version":"4.4.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CPB"],"published-print":{"date-parts":[[2026,10,8]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>Recurrent Vulvovaginal Candidiasis (RVVC) is increasing worldwide, with biofilm\npersistence and antifungal resistance limiting treatment options. The combined use of antifungal\ntreatments with antibiofilm agents has become a promising strategy. This review explores advanced\ntherapeutic approaches, their limitations, and prospects.\nOvergrowth of vaginal Candida inflames the mucosa, causing itching, dryness, and whitish discharge.\nBiofilm formation worsens the condition, contributing to treatment failure, resistance, and\nrecurrence. Conventional antifungal modalities are often inadequate against these multidimensional\nbiofilm assemblies. Combining natural and synthetic antifungal agents with antibiofilm\nadjuncts has shown improved outcomes by targeting Candida cells within biofilms.\nThis review compiles studies on multicomponent approaches to managing vaginal Candida infections,\nfocusing on pan-Candida species to clarify species-specific resistance and persistence. Host\nfactors in non-virgin women, a highly affected population, are examined alongside regional data\non recurrence and treatment failure. Together, these insights highlight the microbiology of Candida\nbiofilms, host and regional influences, and the socio-economic burden of RVVC, while emphasising\nthe translational importance of combination therapy and biotechnology-driven innovations\nsuch as molecular docking, nanocarriers, CRISPR-based gene modulation, and engineered\nprobiotics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0113892010514884261005110150","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:47:06Z","timestamp":1791971226000},"source":"Crossref","is-referenced-by-count":0,"title":["Biotechnological Approaches to Biofilm-Targeted Antifungal Therapy in\nRecurrent Vulvovaginal Candidiasis"],"prefix":"10.2174","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-8103","authenticated-orcid":true,"given":"Nazia","family":"Hassan","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Education and Research, Department of Pharmaceutics, SPER, Jamia Hamdard, New Delhi,110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5476-3108","authenticated-orcid":true,"given":"Asgar","family":"Ali","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Education and Research, Department of Pharmaceutics, SPER, Jamia Hamdard, New Delhi,110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Pharmaceutical Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113892010514884261005110150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/259352\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113892010514884261005110150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:47:11Z","timestamp":1791971231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/259352\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0113892010514884261005110150","relation":{},"ISSN":["1389-2010"],"issn-type":[{"value":"1389-2010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,8]]}}}