{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:54:08Z","timestamp":1782129248360,"version":"3.54.5"},"reference-count":76,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDT"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>This study aimed to investigate the expression of the epidermal growth\nfactor receptor (EGFR) in non-small cell lung cancer (NSCLC) tissues and its association with the\nfrequency of legume food intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Clinical data from 93 NSCLC patients at Jiujiang University-affiliated Hospital\n(2018-2023) were collected. Postoperative recurrence status and legume intake were obtained via\ntelephone follow-up. Fourteen patients with recurrence or metastasis were assigned to the first progression\n(FP) group. Propensity score matching (1:3) was used to select 42 non-progression (NP)\nmatched patients, totaling 56 for analysis. Patients were divided into low- and high-legume intake\ngroups. EGFR expression was assessed by immunohistochemistry and statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>EGFR positivity was higher in the FP group (78.6%, 11\/14) than in the NP group\n(47.6%, 20\/42) (P &lt; 0.05). The NP group had a greater proportion of patients with high-frequency\nlegume consumption compared to the FP group (71.4% vs. 35.7%, P &lt; 0.05). Furthermore, patients\nwith high-frequency legume intake (42.9%, 15\/35) showed significantly lower EGFR positivity\nthan those in the low-frequency intake group (76.2%, 16\/21) (P &lt; 0.05). These results indicate\nthat higher legume intake correlates with both reduced EGFR expression and a decreased postoperative\nrecurrence risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>These findings suggest that higher legume intake is associated with reduced EGFR expression\nand better postoperative outcomes in NSCLC patients. Legume consumption may modulate\ndisease progression through EGFR regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>High legume intake correlates with improved prognosis and lower EGFR expression\nin NSCLC. Further large-scale prospective studies are needed to validate these associations and explore\ntheir clinical implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0113894501406097251015114440","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:22:53Z","timestamp":1769145773000},"page":"281-290","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between EGFR Expression in Non-Small Cell Lung Cancer and Dietary Legume Intake"],"prefix":"10.2174","volume":"27","author":[{"given":"Chengman","family":"Wang","sequence":"first","affiliation":[{"name":"School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China"},{"name":"Jiangxi Provincial Key Laboratory of Preventive Medicine, Jiangxi Medical College, Nanchang University, Nanchang,330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China"},{"name":"Jiangxi Provincial Key Laboratory of Preventive Medicine, Jiangxi Medical College, Nanchang University, Nanchang,330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China"},{"name":"Jiangxi Provincial Key Laboratory of Preventive Medicine, Jiangxi Medical College, Nanchang University, Nanchang,330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China"},{"name":"Jiangxi Provincial Key Laboratory of Preventive Medicine, Jiangxi Medical College, Nanchang University, Nanchang,330006, P.R. 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