{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:08:01Z","timestamp":1780916881135,"version":"3.54.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MRMC"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"\n Introduction:<\/jats:title>\n Wound healing is an important process in tissue regeneration and repair,\nduring which events such as cell movement, proliferation, and tissue remodeling are keyfactor. Several\npathological conditions, such as diabetes, hinder wound-healing processes. Mechanistically,\nhealing processes are governed by many signaling pathways, which also influence scar formation;\nthe ERK\/MAPK pathway is a principal regulator of both wound healing and scar formation. Given\nthe prevalence of chronic wounds worldwide, understanding this pathway is crucial for developing\nbetter treatment strategies.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Recent literature on the role of the ERK\/MAPK pathway in healing chronic\nwounds, particularly in tissue repair and scar formation, was critically reviewed, exploring public\ndatabases and following the PRISMA approach. The findings on decoding the role of ERK pathways\nin wound healing, especially chronic wounds in diabetes, and screening phytomedicines for\ntargeting the ERK\/MAPK cascade are presented.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The ERK\/MAPK pathway controls the major stages of wound healing, viz., inflammation,\ncell migration, proliferation, and collagen deposition.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n Studies suggest that natural remedies, including extracts such as lemongrass, aloe vera\nand phytochemicals like citral, aloesin, catechin, can effectively modulate ERK signaling to shift the\nwound toward healing rather than scar formation. Although some progress has been made, further\nstudies are needed to elucidate the diverse functions of ERK isoforms fully and to develop therapies\nwith greater precision.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n ERK\/MAPK-targeted phytotherapy is a useful intervention strategy that appears to\nfacilitate healing of chronic wounds associated with life-threatening diseases.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/0113895575420185260216070223","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:21:26Z","timestamp":1780914086000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Systematic Review On ERK\/MAPK Signaling Circuit As The Critical Regulator In Chronic Wound Healing: Phytochemicals As Possible Modulators?"],"prefix":"10.2174","volume":"26","author":[{"given":"Krishnendu","family":"Adhikary","sequence":"first","affiliation":[{"name":"Department of Interdisciplinary Science, Centurion University of Technology and Management, Bhubaneswar, Odisha,752050, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurav","family":"Barman","sequence":"additional","affiliation":[{"name":"Department of Soil Science, Centurion University of Technology and Management, Gajapati, Odisha,761211, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riya","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Medical Lab Technology, Dr. B.C. Roy Academy of Professional Courses, Fuljhore, Durgapur, West Bengal, 713206, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnendu","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Medical Lab Technology, Paramedical College Durgapur, West Bengal, 713212, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyajit","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi Jharkhand, 835215, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradipta","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilanjana","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Horticulture, Centurion University of Technology and Management, Gajapati, Odisha, 761211, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumpa","family":"Dhua","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Bankura Sammilani College, Kenduadihi, Bankura, West Bengal, 722102, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bidyut","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Oriental Institute of Science and Technology, Vidyasagar University, Midnapore, West Bengal, 721102, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Maiti","sequence":"additional","affiliation":[{"name":"Department of Physiology, Bankura Christian College, Bankura, West Bengal, 722101, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-9190","authenticated-orcid":true,"given":"Suprabhat","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Integrative Biochemistry & Immunology Laboratory (IBIL), Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal, 713340, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Mini-Reviews in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113895575420185260216070223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/254632\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113895575420185260216070223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:21:50Z","timestamp":1780914110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/254632\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0113895575420185260216070223","relation":{},"ISSN":["1389-5575"],"issn-type":[{"value":"1389-5575","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2025-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}